ID F7C5W3_MACMU Unreviewed; 2102 AA.
AC F7C5W3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Dedicator of cytokinesis 7 {ECO:0000313|Ensembl:ENSMMUP00000003135.4};
GN Name=DOCK7 {ECO:0000313|Ensembl:ENSMMUP00000003135.4,
GN ECO:0000313|VGNC:VGNC:71864};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000003135.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000003135.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000003135.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR SMR; F7C5W3; -.
DR Ensembl; ENSMMUT00000003320.4; ENSMMUP00000003135.4; ENSMMUG00000002340.4.
DR VEuPathDB; HostDB:ENSMMUG00000002340; -.
DR VGNC; VGNC:71864; DOCK7.
DR GeneTree; ENSGT00940000155661; -.
DR HOGENOM; CLU_000624_0_0_1; -.
DR Proteomes; UP000006718; Chromosome 1.
DR Bgee; ENSMMUG00000002340; Expressed in spermatocyte and 21 other cell types or tissues.
DR ExpressionAtlas; F7C5W3; baseline.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08696; C2_Dock-C; 1.
DR CDD; cd11703; DHR2_DOCK7; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR037808; C2_Dock-C.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF78; DEDICATOR OF CYTOKINESIS PROTEIN 7; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT DOMAIN 561..748
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1640..2076
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 138..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 859..933
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..158
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 859..885
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 915..933
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2102 AA; 238491 MW; F81F33004A44C919 CRC64;
MAERRAFAQK ISRTVAAEVR KQISGQYSGS PQLLKNLNIV GNISHHTTVP LTEAVDPVDL
EDYLITHPLA VDSGPLRDLI EFPPDDIEVV YSPRDCRTLV SAVPEESEMD PHVRDCIRSY
TEDWAIVIRK YHKLGTGFNP NTLDKQKERQ KGLPKQVFES DEAPDGNNYQ DDQDDLKRRS
MSIDDTPRGS WACSIFDLKN SLPDALLPNL LDRTPNEEID RQNDDQRKSN RHKELFALHP
SPDEEEPIER LSVPDVPKEH FGQRLLVKCL SLKFEIEIEP IFASLALYDV KEKKKISENF
YFDLNSEQMK GLLRPHVPPA AITTLARSAI FSITYPSQDV FLVIKLEKVL QQGDIGECAE
PYMIFKEADA TKNKEKLEKL KSQADQFCQR LGKYRMPFAW TAIHLMNIVS SAGSLERDST
EVEISTGERK GSWSERRNSS IVGRRSLERT TSGDDACNLT SFRPATLTVT NFFKQEGDRL
SDEDLYKFLA DMRRPSSVLR RLRPITAQLK IDISPAPENP HYCLTPELLQ VKLYPDSRVR
PTREILEFPA RDVYVPNTTY RNLLYIYPQS LNFANRQGSA RNITVKVQFM YGEDPSNAMP
VIFGKSSCSE FSKEAYTAVV YHNRSPDFHE EIKVKLPATL TDHHHLLFTF YHVSCQQKQN
TPLETPVGYT WIPMLQNGRL KTGQFCLPVS LEKPPQAYSV LSPEDPYLDK FFALVNALDE
HMFPVRIGDM RIMENNLENE LKSSISALNS SQLEPVVRFL HLLLDKLILL VVRPPVIAGQ
IVNLGQASFE AMASIINRLH KNLEGNHDQH GRNSLLASYI HYVFRLPNTY PNSSSPGPGG
LGGSVHYATM ARSAVRPASL NLNRSRSLSN SNPDISGTPT SPDDEVRSII GSKGLDRSNS
WVNTGGPKAA PWGSNPSPSA ESTQAVDRSC NRMSSHTETS SFLQTLTGRL PTKKLFHEEL
ALQWVVCSGS VRESALQQAW FFFELMVKSM VHHLYFNDKL DAPRKSRFPE RFMDDIAALV
STIASDIVSR FQKDTEMVER LNTSLAFFLN DLLSVMDRGF VFSLIKSCYK QVSSKLYSLP
NPSILVSLRL DFLRIICSHE HYVTLNLPCS LLTPPASPSP SVSSATSQSS GFSTNVQDQK
IANMFELSVP FRQQHYLAGL VLTELAVILD PDAEGLFGLH KKVINMVHNL LSSHDSDPRY
SDPQIKARVA MLYLPLIGII METVPQLYDF TETHNQRGRP ICIATDDHES ESGSMISQTV
AMAIAGTSVP QLTRPGSFLL TSTSGRQHTT FSAESSRSLL ICLLWVLKNA DETVLQKWFT
DLSVLQLNRL LDLLYLCVSC FEYKGKKVFE RMNSLTFKKS KDMRAKLEEA ILGSIGARQE
MVRRSRGQLE RSPSGSAFGS QENLRWRKDM THWRQNTEKL DKSRAEIEHE ALIDGNLATE
ANLIILDTLE IVVQTVSVTE SKESILGGVL KVLLHSMACN QSAVYLQHCF ATQRALVSKF
PELLFEEETE QCADLCLRLL RHCSSSISTI RSHASASLYL LMRQNFEIGN NFARVKMQVT
MSLSSLVGTS QNFNEEFLRR SLKTILTYAE EDLELRETTF PDQVQDLVFN LHMILSDTVK
MKEHQEDPEM LIDLMYRIAK GYQTSPDLRL TWLQNMAGKH SERSNHAEAA QCLVHSAALV
AEYLSMLEDR KYLPVGCVTF QNISSNVLEE SAVSDDVVSP DEEGICSGKY FTESGLVGLL
EQAAASFSMA GMYEAVNEVY KVLIPIHEAN RDAKKLSTIH GKLQEAFSKI VHQSTGWERM
FGTYFRVGFY GTKFGDLDEQ EFVYKEPAIT KLAEISHRLE GFYGERFGED VVEVIKDSNP
VDKCKLDPNK AYIQITYVEP YFDTYEMKDR ITYFDKNYNL RRFMYCTPFT LDGRAHGELH
EQFKRKTILT TSHAFPYIKT RVNVTHKEEI ILTPIEVAIE DMQKKTQELA FATHQDPADP
KMLQMVLQGS VGTTVNQGPL EVAQVFLSEI PSDPKLFRHH NKLRLCFKDF TKRCEDALRK
NKSLIGPDQK EYQRELERNY HRLKEALQPL INRKIPQLYK AVLPVTCHRD SFSRMSLRKM
DL
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