ID F7C5Y0_MACMU Unreviewed; 539 AA.
AC F7C5Y0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=Cochlin {ECO:0000256|ARBA:ARBA00013828};
GN Name=COCH {ECO:0000313|Ensembl:ENSMMUP00000015109.3,
GN ECO:0000313|VGNC:VGNC:71288};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000015109.3, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000015109.3}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000015109.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in the control of cell shape and motility in the
CC trabecular meshwork. {ECO:0000256|ARBA:ARBA00003388}.
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DR AlphaFoldDB; F7C5Y0; -.
DR SMR; F7C5Y0; -.
DR Ensembl; ENSMMUT00000016122.3; ENSMMUP00000015109.3; ENSMMUG00000011514.4.
DR VEuPathDB; HostDB:ENSMMUG00000011514; -.
DR VGNC; VGNC:71288; COCH.
DR GeneTree; ENSGT00940000159386; -.
DR TreeFam; TF318242; -.
DR Proteomes; UP000006718; Chromosome 7.
DR Bgee; ENSMMUG00000011514; Expressed in olfactory segment of nasal mucosa and 22 other cell types or tissues.
DR ExpressionAtlas; F7C5Y0; baseline.
DR CDD; cd01472; vWA_collagen; 1.
DR CDD; cd01482; vWA_collagen_alphaI-XII-like; 1.
DR Gene3D; 2.170.130.20; LCCL-like domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR InterPro; IPR004043; LCCL.
DR InterPro; IPR036609; LCCL_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020:SF36; COCHLIN; 1.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR Pfam; PF03815; LCCL; 1.
DR Pfam; PF00092; VWA; 2.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00603; LCCL; 1.
DR SMART; SM00327; VWA; 2.
DR SUPFAM; SSF69848; LCCL domain; 1.
DR SUPFAM; SSF53300; vWA-like; 2.
DR PROSITE; PS50820; LCCL; 1.
DR PROSITE; PS50234; VWFA; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..539
FT /note="Cochlin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023860740"
FT DOMAIN 17..110
FT /note="LCCL"
FT /evidence="ECO:0000259|PROSITE:PS50820"
FT DOMAIN 154..339
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 356..526
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 117..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 539 AA; 58766 MW; CDC5BF5F4C81DCC1 CRC64;
TSFFLRMLTI LSPFSSAPIA ITCFTRGLDI RKEKADVLCP GGCPLEEFSV YGNIVYASVS
SICGAAVHRG VISNSGGPVR VYSLPGRENY SSVDANGIQS QMLSRWSASF TVTKGKSSTQ
EATGQAVSTA HPPTGKRLKK TPEKKTGNKD CKADIAFLID GSFNIGQRRF NLQKNFVGKV
ALMLGIGTEG PHVGLVQASE HPKIEFYLKN FTSAKDVLFA IKEVGFRGGN SNTGKALKHT
AQKFFTVDAG VRKGIPKVVV VFIDGWPSDD IEEAGIVARE FGVNVFIVSV AKPIPEELGM
VQDVTFVDKA VCRNNGFFSY HMPNWFGTTK YVKPLVQKLC THEQMMCSKT CYNSVNIAFL
IDGSSSVGDS NFRLMLEFVS NIAKTFEISD IGAKIAAVQF TYDQRTEFSF TDYSTKEDVL
AVIRNIRYMS GGTATGDAIS FTVRNVFGPI RESPNKNFLV IVTDGQSYDD VQGPAAAAHD
AGITIFSVGV AWAPLDDLKD MASKPKESHA FFTREFTGLE PIVSDVIRGI CRDFLESQQ
//
