ID F7C6J9_ORNAN Unreviewed; 759 AA.
AC F7C6J9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Centromere protein T {ECO:0000256|ARBA:ARBA00016401};
GN Name=CENPT {ECO:0000313|Ensembl:ENSOANP00000008254.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000008254.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000008254.3, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000008254.3,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000008254.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000008254.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CENP-T/CNN1 family.
CC {ECO:0000256|ARBA:ARBA00010137}.
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DR AlphaFoldDB; F7C6J9; -.
DR Ensembl; ENSOANT00000008256.3; ENSOANP00000008254.3; ENSOANG00000005197.3.
DR GeneTree; ENSGT00390000003044; -.
DR HOGENOM; CLU_040180_0_0_1; -.
DR InParanoid; F7C6J9; -.
DR OMA; YFQHLCN; -.
DR OrthoDB; 2919543at2759; -.
DR Proteomes; UP000002279; Chromosome 11.
DR Bgee; ENSOANG00000005197; Expressed in testis and 7 other cell types or tissues.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IBA:GO_Central.
DR GO; GO:0051382; P:kinetochore assembly; IEA:InterPro.
DR GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR InterPro; IPR028255; CENP-T.
DR InterPro; IPR035425; CENP-T/H4_C.
DR InterPro; IPR032373; CENP-T_N.
DR InterPro; IPR009072; Histone-fold.
DR PANTHER; PTHR46904; CENTROMERE PROTEIN T; 1.
DR PANTHER; PTHR46904:SF1; CENTROMERE PROTEIN T; 1.
DR Pfam; PF15511; CENP-T_C; 1.
DR Pfam; PF16171; CENP-T_N; 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT DOMAIN 4..499
FT /note="Centromere kinetochore component CENP-T N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16171"
FT DOMAIN 651..744
FT /note="CENP-T/Histone H4 histone fold"
FT /evidence="ECO:0000259|Pfam:PF15511"
FT REGION 1..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 293..650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..45
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..381
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..523
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..582
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 759 AA; 82338 MW; A6BB8DA120376DCD CRC64;
MASLPEDDLT TRTLLKRVLA TEPPHTPLPV PGHDRKPKLE TRRRSLRLSG PPLPPPETPA
TSSPSMTLRN RMKERVRRSM RITRASSSRP PESQASSRPA PPRRDKMDEE TPRTILRNIM
QTAPEASMLV PNSPAPAVEE VQPLQESRQS SLDLQLPELE PLVPMARAQL GTGRKRRKLR
LSEFERGVDQ GLAASVGAPS LTIPAEEPLA SANTSSLTKS FNLSLTALVL PESVKRPGLA
RRPRTRKAIS LEAFEQGLEK TPLPTQEAAQ AASADSWVVA DTLLGDTQLF LQASPWDQSR
PHHSQVQPAG EGKQDPDKAD AHQTRSPSSA ASRLSPARQV DGASRSLDGA QVSRQSLGIR
HSARFTPTRN KDIREAGAEP GHRSGMELAA VGEREARAVE EEGQVAGLAG KGKAAPLAGE
DVATTAMGER EGTPLAGEDG TSAVTGEGKA ASLAEEDEAH ILEAEEEAEV AESVEEEKEG
EVVSEEDGAT VEEEESEEAE SIEEEEGDEV AAMGEEEDEV TPLVEKDEAV TVGEEEDEAV
TTEEEAEAIE EDEVMEEDEP EPLVEEDGLA TTEEEEVETE AEGSEEHTGA VQEAEISLKT
PAFIQAKRQQ AFAPSASPSP ARSPPKSFPT KQARARGPAR APRPPRTPGS ALLSHYAKIF
GFYAKMPVEK AAYKVVEKSL DRYFRQLGDD LEVFTSHAGR KTVEAEDLEL LMRRQGLVTD
DVSLHVLVER HLPMEYRRLL IPCATSGNRV SPALGQRKL
//
