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Database: UniProt
Entry: F7C733_ORNAN
LinkDB: F7C733_ORNAN
Original site: F7C733_ORNAN 
ID   F7C733_ORNAN            Unreviewed;      1409 AA.
AC   F7C733;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 2.
DT   24-JAN-2024, entry version 53.
DE   RecName: Full=Alpha-2-macroglobulin {ECO:0008006|Google:ProtNLM};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000022376.2, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Ensembl:ENSOANP00000022376.2}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000022376.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBUNIT: Homotetramer; disulfide-linked.
CC       {ECO:0000256|ARBA:ARBA00038769}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC       macroglobulin) family. {ECO:0000256|ARBA:ARBA00010952}.
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DR   Ensembl; ENSOANT00000022380.3; ENSOANP00000022376.2; ENSOANG00000014192.4.
DR   GeneTree; ENSGT00940000154904; -.
DR   HOGENOM; CLU_001634_2_1_1; -.
DR   Proteomes; UP000002279; Unplaced.
DR   Bgee; ENSOANG00000014192; Expressed in liver and 5 other cell types or tissues.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   CDD; cd02897; A2M_2; 1.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 2.20.130.20; -; 1.
DR   Gene3D; 2.60.120.1540; -; 1.
DR   Gene3D; 2.60.40.1930; -; 3.
DR   Gene3D; 2.60.40.1940; -; 1.
DR   Gene3D; 6.20.50.160; -; 1.
DR   Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR   InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR041813; A2M_TED.
DR   InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR   InterPro; IPR011626; Alpha-macroglobulin_TED.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR019742; MacrogloblnA2_CS.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR041555; MG3.
DR   InterPro; IPR040839; MG4.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR11412:SF165; ALPHA-2-MACROGLOBULIN; 1.
DR   PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF07677; A2M_recep; 1.
DR   Pfam; PF01835; MG2; 1.
DR   Pfam; PF17791; MG3; 1.
DR   Pfam; PF17789; MG4; 1.
DR   Pfam; PF07678; TED_complement; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
DR   SMART; SM01361; A2M_recep; 1.
DR   SMART; SM01419; Thiol-ester_cl; 1.
DR   SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR   PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..1409
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5028034996"
FT   DOMAIN          404..563
FT                   /note="Alpha-2-macroglobulin bait region"
FT                   /evidence="ECO:0000259|SMART:SM01359"
FT   DOMAIN          674..764
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000259|SMART:SM01360"
FT   DOMAIN          1313..1400
FT                   /note="Alpha-macroglobulin receptor-binding"
FT                   /evidence="ECO:0000259|SMART:SM01361"
FT   REGION          867..893
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1409 AA;  155129 MW;  231F1D3A56133992 CRC64;
     MGGRRLPRFS LFLLFLGLLA TNTSAAPEQY MLLISSLLHA EVPEKACILL SHLNETVTLS
     AVLEYGTENR SLVANLVDDL VANKDTFHCS PFTVRGSWTT VAFLSVRVKG PTQEFRKRKA
     VLVRNMQSLV FVQTDKPIYK PGQTVRFRVV SVDEDFHPLN ETVSQMDPKR NRIAQWRDVR
     LRDGFGQFSF PLSSEPSQGQ YKVVVQKESG ARKEHPFTVE EFVLPKFEVL VKMPKKITIL
     DEEIAVSVCG IYTYGKPVPG TVTWSVCRRF SQGQSECYGK ESEAICEEFS QQADSQGCVS
     GVIETKLFQL KQQGFLMNIE AEATIREEGT ELELSGRAVC EVTKTLSKIT FEKVDSHFRR
     GLPFFGQVRL LDGKDAPIPN ALVQVSVDAT HHLSNHSTDE YGLVQFSIDT SNFTTAPISV
     RVTYKDSPVC YDYKWLSGNH ESAEHKAKHV YSASQNYIRL EPISDTLVCG HQQDIHKGSF
     SVELLVGPEI APVMRFLIYS ILPDGEVVAD SEKFNIEKCF SNKVELQFSS IHTLPGSGAR
     LRVTASPQSL CALRALDQSV LLLKAEAELS PSSVYSLLPE QDLEGFPEGL RNLGNDLRNC
     TKVQPIIVNG IPFFPMDSPD EDDAYSFLKV KSLFPTEMLL LEGKQCRSKW TALNEVSWES
     SVQAETVRKY FPEAWIWELL VVDTSGQSEV AVTIPDTITE WKVGAFCLSA ATGLGLAPTT
     SLRAFQPFFL ELTLPYSMVR GEGFPLKATV FSYLPGCIRV SVQLEASPDF LAVPMEKGAC
     SHCICGSGRL TLSWMVTPSS LGEVMFSVSA EALQSPELCG NEAAEVPEVG RKDTVIRTLL
     VEPEGIEKEE TFNSLLCVKG ETLQPLMDNP APPWRGNNGE GSPRGPTSPR GDILGSALQN
     LQNLLQMPYG CGEQNMVLFA PNIYVLNYLN KTQQLTPSIR AQAMGYLSSG YQRQLNYKHQ
     DGSYSTFGEH HGSSQGNTWL TAFVLKALAQ ARAHIFVDEE HISSALLWLS GKQKDNGCFL
     SSGSLLNNAI KGGVDNEVTL SAYITTALLE MPLPATHPVV RNALYCLETA WRAMAGNPDS
     HVYTKALLAY AFALAGHEAQ RREVLQALDR DAVRAGGSIH WQRSGQAPAS IQPQGWGRAP
     SAEVEMTAYV LLARLTAQPA PSPEDLSTAA LIIQWIAKQQ NAHGGFSSTQ DTVVALHALA
     QYGTATFNRE GKAAVTVRSK GTFSKEFHVE DDNRLLVQQV ALAEVPGEYS ATVTGAGCVY
     LQTSLRYNIV AGQGKSPIAL QVQTIPQSCS EVEAEKTFQI SISASYTGSR PASNMVIADV
     KMVSGFIPLK SSVKMLQESN HVSRTEVTNN HVLIYLEQLT NETLSLTFTV TQDVLVQNLR
     PAPVRVYDYY ETDEVAIVEY SAPCSTGRV
//
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