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Database: UniProt
Entry: F7C9G0_ORNAN
LinkDB: F7C9G0_ORNAN
Original site: F7C9G0_ORNAN 
ID   F7C9G0_ORNAN            Unreviewed;       422 AA.
AC   F7C9G0;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 2.
DT   20-JUN-2018, entry version 50.
DE   RecName: Full=Aldehyde dehydrogenase {ECO:0000256|PIRNR:PIRNR036492};
GN   Name=LOC100083368 {ECO:0000313|Ensembl:ENSOANP00000006939};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000006939, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Proteomes:UP000002279}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279};
RX   PubMed=18464734; DOI=10.1038/nature06936;
RA   Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E.,
RA   Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L.,
RA   Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P.,
RA   Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J.,
RA   Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L.,
RA   Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P.,
RA   Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A.,
RA   Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A.,
RA   Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J.,
RA   Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A.,
RA   Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA   Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA   Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA   Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H.,
RA   Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y.,
RA   Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y.,
RA   Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K.,
RA   Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J.,
RA   Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M.,
RA   Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R.,
RA   Wilson R.K.;
RT   "Genome analysis of the platypus reveals unique signatures of
RT   evolution.";
RL   Nature 453:175-183(2008).
RN   [2] {ECO:0000313|Ensembl:ENSOANP00000006939}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000006939};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|PIRNR:PIRNR036492, ECO:0000256|RuleBase:RU003345}.
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DR   RefSeq; XP_007657433.1; XM_007659243.1.
DR   STRING; 9258.ENSOANP00000006939; -.
DR   Ensembl; ENSOANT00000006941; ENSOANP00000006939; ENSOANG00000004381.
DR   GeneID; 100083368; -.
DR   KEGG; oaa:100083368; -.
DR   eggNOG; KOG2450; Eukaryota.
DR   eggNOG; COG1012; LUCA.
DR   GeneTree; ENSGT00760000118999; -.
DR   InParanoid; F7C9G0; -.
DR   KO; K00129; -.
DR   OrthoDB; EOG091G05E8; -.
DR   TreeFam; TF300455; -.
DR   Proteomes; UP000002279; Unplaced.
DR   Bgee; ENSOANG00000004381; -.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD) activity; IBA:GO_Central.
DR   GO; GO:0006081; P:cellular aldehyde metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.309.10; -; 1.
DR   Gene3D; 3.40.605.10; -; 2.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR012394; Aldehyde_DH_NAD(P).
DR   Pfam; PF00171; Aldedh; 1.
DR   PIRSF; PIRSF036492; ALDH; 1.
DR   SUPFAM; SSF53720; SSF53720; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002279};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR036492,
KW   ECO:0000256|RuleBase:RU003345};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT   DOMAIN        2    413       Aldedh. {ECO:0000259|Pfam:PF00171}.
FT   ACT_SITE    190    190       {ECO:0000256|PIRSR:PIRSR036492-1}.
FT   ACT_SITE    224    224       {ECO:0000256|PIRSR:PIRSR036492-1}.
SQ   SEQUENCE   422 AA;  46215 MW;  3F9107855A5320A8 CRC64;
     MDALSRGRLL HKLADLIERD RIILATLETM DTGKPFLHAF FIDLEGCIKT LRYYAGWADK
     VQGRTIPADE NVVCFTRHEP IGVCGAITPW NFPLLMLIWK MAPALCCGNT LVIKPAEQTP
     LTALYLGSLI KEVGFPPGVV NIVPGYGPTA GAAISAHPKI DKIAFTGSTE VGKLIKEAAS
     KSNLKRVTLE LGGKNPCIVC ADADLDLAVE CAHQGVFLNQ GQCCTAASRV FVEEQIYPEF
     VKRSVEYAKK RLVGDPFDAK TEQGPQIDQK QFDKILELIE SGKKEGAKLE CGGSAIEDRG
     LFIKPTVFSD VTDNMRIARE EIFGPVQPIL KFKSMEEVIK RANNIEYGLT AAVFTKNLDK
     ALKLASALES GTVWINCYNA IYAQAPFGGF KMSGNGRELG EYALAEYTEV KTVTIKLSEK
     NL
//
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