ID F7CCG5_XENTR Unreviewed; 994 AA.
AC F7CCG5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=Signal peptide, CUB domain, EGF-like 1 {ECO:0000313|Ensembl:ENSXETP00000026833};
GN Name=scube1 {ECO:0000313|Ensembl:ENSXETP00000026833};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000026833};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000026833}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000026833};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000026833}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; F7CCG5; -.
DR Ensembl; ENSXETT00000026833; ENSXETP00000026833; ENSXETG00000012277.
DR AGR; Xenbase:XB-GENE-1009947; -.
DR AGR; Xenbase:XB-GENE-854777; -.
DR Xenbase; XB-GENE-1009947; scube1.
DR eggNOG; KOG1217; Eukaryota.
DR HOGENOM; CLU_013079_0_0_1; -.
DR OrthoDB; 688990at2759; -.
DR TreeFam; TF351672; -.
DR Bgee; ENSXETG00000012277; Expressed in brain and 13 other cell types or tissues.
DR ExpressionAtlas; F7CCG5; baseline.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF4; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 3.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM01411; Ephrin_rec_like; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 5.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 6.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 14..54
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 97..133
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 292..332
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 333..371
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 805..917
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 337..347
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 994 AA; 110111 MW; 9805C9A84B3D8C21 CRC64;
MAPSNLLRSL DRVNSDECAE GTDDCHIDAI CQNTPKSYKC ICKAGFKGEG KQCEDIDECD
NDYNGGCVHE CINIPGNYRC TCYDGFMLAH DGHNCLDVDE CLDNNGGCQQ ICVNTMGSYE
CQCKDGFFLS DNQHTCIHRS NEGMNCMNKD HGCAHICRET PKVGVACECR PGFELAKNQR
DCTLTCNYGN GGCQHTCDDT DTGPVCGCHQ KYALHSDGRT CIVSSSGSAE MTTQTDTRPF
HLCYGPRHTQ CTETCAVNNG GCDRTCKDTA TGVRCSCPVG FTLQPDGKTC KDIDECLVNN
GGCDHFCRNT VGSFECSCQR GYKLLTDERS CQDVDECSFE RTCDHICINY PGSYECLCHK
GYTLYGMTHC GDINECSINN GSCDYGCVNT PGSYECVCPP GKRLHWNKKD CIEMVKCLPN
SKPPPRAQLI CSKAGGIDSC FLSCPSNTLF VPDSESSYTL SCGVPVQQGK SVQKRNATVP
SSCGDSLGPP ITQKARFKIK DAKCHLRPRS KEKIRESGRQ SPTDNCHVTF VNLKCDSSKK
KRRGRNSPAK EVSHITAEFE LEIKREEVTD SCNSDCVRRR MEQKLQTAIK TLRKSINKQQ
FYIQFSGAEY EVAQKPAKVS EVQEPCSAGQ ILLDGKCVFC PAGTFYNGEH NQCIPCSPGT
YQDTRGQLTC EPCPSNDGSG IGGARNVSEC GGQCAPGYFS LDGFKPCRSC PLGTYQPESG
RTLCFPCGGG LVTKYESAVS FQDCETKVHC SPGHYYNSTT HRCIRCPIGT YQPEFGLNFC
ITCPGNTSTD FDGSTNVTHC KNQHCGGELG DYTGYIESPN YPGDYPAHVE CIWNINPPPK
RRILIVVPEI FLPIEDECGD VLVMRKSASP ASITTYETCQ TYERPIAFTS RSRKLWIQFK
SNEGNSGKGF QVPYVTYDED YQQLIEDIVR DGRLYASDNH QEILKDKKLI KALFSVLAHP
QNYFKYAEES KKMFPMSFIK LLRSKVSRFL RPYK
//
