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Database: UniProt
Entry: F7CCV0_HORSE
LinkDB: F7CCV0_HORSE
Original site: F7CCV0_HORSE 
ID   F7CCV0_HORSE            Unreviewed;      1411 AA.
AC   F7CCV0;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 2.
DT   31-JUL-2019, entry version 59.
DE   SubName: Full=Drosha ribonuclease III {ECO:0000313|Ensembl:ENSECAP00000012122};
GN   Name=DROSHA {ECO:0000313|Ensembl:ENSECAP00000012122,
GN   ECO:0000313|VGNC:VGNC:17318};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000012122, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000012122, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000012122,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000012122}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000012122};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   PaxDb; F7CCV0; -.
DR   Ensembl; ENSECAT00000015113; ENSECAP00000012122; ENSECAG00000013578.
DR   VGNC; VGNC:17318; DROSHA.
DR   eggNOG; KOG1817; Eukaryota.
DR   eggNOG; COG0571; LUCA.
DR   GeneTree; ENSGT00730000111052; -.
DR   InParanoid; F7CCV0; -.
DR   OMA; EYLYRHF; -.
DR   OrthoDB; 935825at2759; -.
DR   TreeFam; TF314734; -.
DR   Proteomes; UP000002281; Chromosome 21.
DR   Bgee; ENSECAG00000013578; Expressed in 3 organ(s), highest expression level in prefrontal cortex.
DR   GO; GO:0070877; C:microprocessor complex; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR   GO; GO:0017151; F:DEAD/H-box RNA helicase binding; IEA:Ensembl.
DR   GO; GO:0003725; F:double-stranded RNA binding; IBA:GO_Central.
DR   GO; GO:0001530; F:lipopolysaccharide binding; IEA:Ensembl.
DR   GO; GO:0070878; F:primary miRNA binding; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0070412; F:R-SMAD binding; IEA:Ensembl.
DR   GO; GO:0004525; F:ribonuclease III activity; IBA:GO_Central.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:Ensembl.
DR   GO; GO:0010586; P:miRNA metabolic process; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0031054; P:pre-miRNA processing; IBA:GO_Central.
DR   GO; GO:0031053; P:primary miRNA processing; IBA:GO_Central.
DR   GO; GO:0030422; P:production of siRNA involved in RNA interference; IBA:GO_Central.
DR   GO; GO:0050727; P:regulation of inflammatory response; IEA:Ensembl.
DR   GO; GO:2000628; P:regulation of miRNA metabolic process; IEA:Ensembl.
DR   GO; GO:0045589; P:regulation of regulatory T cell differentiation; IEA:Ensembl.
DR   GO; GO:0006396; P:RNA processing; IBA:GO_Central.
DR   GO; GO:0016075; P:rRNA catabolic process; IEA:InterPro.
DR   CDD; cd00048; DSRM; 1.
DR   CDD; cd00593; RIBOc; 2.
DR   Gene3D; 1.10.1520.10; -; 1.
DR   HAMAP; MF_00104; RNase_III; 1.
DR   InterPro; IPR014720; dsRBD_dom.
DR   InterPro; IPR011907; RNase_III.
DR   InterPro; IPR000999; RNase_III_dom.
DR   InterPro; IPR036389; RNase_III_sf.
DR   Pfam; PF00035; dsrm; 1.
DR   Pfam; PF14622; Ribonucleas_3_3; 1.
DR   Pfam; PF00636; Ribonuclease_3; 1.
DR   SMART; SM00358; DSRM; 1.
DR   SMART; SM00535; RIBOc; 2.
DR   SUPFAM; SSF69065; SSF69065; 2.
DR   PROSITE; PS50137; DS_RBD; 1.
DR   PROSITE; PS00517; RNASE_3_1; 2.
DR   PROSITE; PS50142; RNASE_3_2; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24   1411       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5018558321.
FT   DOMAIN      913   1093       RNase III. {ECO:0000259|PROSITE:PS50142}.
FT   DOMAIN     1144   1270       RNase III. {ECO:0000259|PROSITE:PS50142}.
FT   DOMAIN     1297   1371       DRBM. {ECO:0000259|PROSITE:PS50137}.
FT   REGION      167    446       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      484    533       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COILED      848    868       {ECO:0000256|SAM:Coils}.
FT   COILED     1382   1402       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS    167    201       Pro-rich. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    214    241       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    254    352       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    390    432       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    484    515       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    516    530       Acidic. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   1411 AA;  163249 MW;  420142965FDDEC5F CRC64;
     MFCSVSSLGN IFMSILFFLS SRACILCGRC DISRQYVMMQ GSTCHRMSFH PGRGCPRGRG
     GHGARPSAPA FRPQNLRLLH PQQPPVQYQY EPPSAPSTTF SNSPAPNFLP PRPDFVPFPP
     PMPPSAQGPL PPCPIRPPFP NHQMRPPFPV PPCFPPIPPP MPCPNNPPVP GAPPGQGTFP
     FMMPPPSMPH PPPPPVMPQQ VNYQYPPGYS HHNFPPPNFN SFQNNPSSFP PSANNSSSPH
     FRHLPPYPLP KAPSERRSPE RLKHYDDHRH RDHSHGRGER HRSLDRRERG RSPDRRRQES
     RYRSDYDRGR TPSRHRSYER SRERERERHR HRDSRRSPSL ERSYKKEYKR SGRSYGLPVV
     PEPAGCTPES PGEIIKNTDS WAPPLETVNH RSPSREKKRA RWEEEKDRWS DTQSSGKEKN
     YTSIKEKEAE ETPPDKNEEE EEELLKPVWI RCTHSENYYS SDPMDQVGDS TVVGTSRLRD
     LYDKFEEELG SRQEKAKAAR PPWEPPKTKL DEDLESSSES ECESDEDSTC SSSSDSEVFD
     VIAEIKRKKA HPDRLHDELW YNDPGQMNDG PLCKCSAKAR RTGIRHSIYP GEEAIKPCRP
     MTNNAGRLFH YRITVSPPTN FLTDRPTVIE YDDHEYIFEG FSMFAHAPLT NIPLCKVIRF
     NIDYTIHFIE EMMPENFCVK GLELFSLFLF RDILELYDWN LKGPLFEDSP PCCPRFHFMP
     RFVRFLPDGG KEVLSMHQIL LYLLRCSKAL VPEEEIANML QWEELEWQKY AEECKGMIVT
     NPGTKPSSVR IDQLDREQFN PDVITFPIIV HFGIRPAQLS YAGDPQYQKL WKSYVKLRHL
     LANSPKVKQT DKQKLAQREE ALQKIRQKNT MRREVTVELS SQGFWKTGIR SDVCQHAMML
     PVLTHHIRYH QCLMHLDKLI GYTFQDRCLL QLAMTHPSHH LNFGMNPDHA RNSLSNCGIR
     QPKYGDRKVH HMHMRKKGIN TLINIMSRLG QDDPTPSRIN HNERLEFLGD AVVEFLTSVH
     LYYLFPSLEE GGLATYRTAI VQNQHLAMLA KKLELDRFML YAHGPDLCRE SDLRHAMANC
     FEALIGAVYL EGSLEEAKQL FGRLLFNDPD LREVWLNYPL HPLQLQEPNT DRQLIETSPV
     LQKLTEFEEA IGVIFTHVRL LARAFTLRTV GFNHLTLGHN QRMEFLGDSI MQLVATEYLF
     IHFPDHHEGH LTLLRSSLVN NRTQAKVAEE LGMQEYAITN DKTKRPVALR TKTLADLLES
     FIAALYIDKD LEYVHTFMNV CFFPRLKEFI LNQDWNDPKS QLQQCCLTLR TEGKEPDIPL
     YKTLQTVGPS HARTYTVAVY FKGERIGCGK GPSIQQAEMG AAMDALEKYN FPQMAHQKRF
     IERKYRQELK EMRWEREHQE KEPDETEDIK K
//
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