ID F7CI17_MONDO Unreviewed; 953 AA.
AC F7CI17;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Inter-alpha-trypsin inhibitor heavy chain 2 {ECO:0000313|Ensembl:ENSMODP00000020861.3};
GN Name=ITIH2 {ECO:0000313|Ensembl:ENSMODP00000020861.3};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000020861.3, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000020861.3, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000020861.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the ITIH family.
CC {ECO:0000256|ARBA:ARBA00010158}.
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DR RefSeq; XP_001365240.2; XM_001365203.4.
DR AlphaFoldDB; F7CI17; -.
DR STRING; 13616.ENSMODP00000020861; -.
DR Ensembl; ENSMODT00000021228.4; ENSMODP00000020861.3; ENSMODG00000016710.4.
DR GeneID; 100011375; -.
DR KEGG; mdo:100011375; -.
DR CTD; 3698; -.
DR eggNOG; ENOG502QPS2; Eukaryota.
DR GeneTree; ENSGT00940000157945; -.
DR HOGENOM; CLU_008101_0_1_1; -.
DR InParanoid; F7CI17; -.
DR OMA; AKQMWAY; -.
DR OrthoDB; 608326at2759; -.
DR TreeFam; TF328982; -.
DR Proteomes; UP000002280; Chromosome 8.
DR Bgee; ENSMODG00000016710; Expressed in liver and 14 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005540; F:hyaluronic acid binding; IEA:Ensembl.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0030212; P:hyaluronan metabolic process; IEA:InterPro.
DR CDD; cd01461; vWA_interalpha_trypsin_inhibitor; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR010600; ITI_HC_C.
DR InterPro; IPR013694; VIT.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10338; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER; 1.
DR PANTHER; PTHR10338:SF14; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H2; 1.
DR Pfam; PF06668; ITI_HC_C; 1.
DR Pfam; PF08487; VIT; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00609; VIT; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51468; VIT; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..953
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003355204"
FT DOMAIN 59..188
FT /note="VIT"
FT /evidence="ECO:0000259|PROSITE:PS51468"
FT DOMAIN 313..496
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
SQ SEQUENCE 953 AA; 107519 MW; 49103EEC2E8C00D4 CRC64;
MKRLLGFLLF VLLSEERSLH LPSNGLPEFM DYADLADLDL ENLPFALENR RYQRSIFDDQ
ESDKVMENVD DQITLYSYKV KSTVTSRVAN TVVQCKVVNN SPYSQNVELD VQIPRGAFVT
NFSMIVNGVT FTSTIKERTV ARGLYAQARA RGKTAGWVSS NSLDMENFKT EVNVLPGSNV
QFELHYQEVK WRKLGSYEHK LYLKPGRLAK HLEVDIWIVE PQGISFLHVP ENLGDHFEGV
PVITKSKQKG HVSFKPTVDQ QRKCPNCSET AVDGQLVIKY DVVREKKAGE LEVFNGYFVH
FFAPENLDPI PKNILFVIDV SGSMWGIKMK QTVEAMKTIL DDLRAEDQFS VVDFNHNVRN
WRDDLVLASK AQITDAKKYI EKIQPNGGTN INEALLRAIF ILNEASNLGM LDPNSVSLII
LVSDGDPTVG ELKLSQIQKN VKQSMQDNIS LFSLGIGFDV DYDFLERLSQ ENHGVAQRIY
GNQDTSLQLK QFYNQVSTPL LRNVQFNYPQ EYVTDVTQNS FHNYFGGSEI VVAGKVEPDK
LDHVESIITA TSANTQLVMD TLAEMEDLDA FLSKDKHADP DFTRKLWAYL TINQLLAERS
LATTNIDKKK ITRTILQMSL DHHVVSPLTA MLIESADGNE RMLADAPMDQ KRPCCRGALS
TGKKTAQSSI PSWAKPPPTM GPMSVREAPV LISTPPPHVI RVENDPHFII YLPKSQKNIC
FNIDSEPGKI LNLVSDPGTG VLVNGELVGA KMPKNKKLST YFGKLAFYFQ SQDTKIEIST
EMITLKNGHH TTILSWLDTA HIVHKKLLVS VKKEKTVNIT MDGDMSFSVL LHRVWKKHPV
NVDFLGIYIP PTNKFSLNAH GLIGQFMHEP KVRIFNERPG RVPGKPEASM EVKGHKLTVT
RGLQKDYRTD IVLGTDVPCW FVHNSGKGFL DGHYKDYLVP QLYSFLKEPF KNV
//
