ID F7CJZ9_ORNAN Unreviewed; 1057 AA.
AC F7CJZ9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=ST18 C2H2C-type zinc finger transcription factor {ECO:0000313|Ensembl:ENSOANP00000011582.3};
GN Name=ST18 {ECO:0000313|Ensembl:ENSOANP00000011582.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000011582.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000011582.3, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000011582.3,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000011582.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000011582.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MYT1 family.
CC {ECO:0000256|ARBA:ARBA00010194}.
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DR AlphaFoldDB; F7CJZ9; -.
DR Ensembl; ENSOANT00000011584.3; ENSOANP00000011582.3; ENSOANG00000007275.3.
DR eggNOG; KOG3803; Eukaryota.
DR GeneTree; ENSGT00940000159905; -.
DR HOGENOM; CLU_007226_0_0_1; -.
DR OrthoDB; 3091993at2759; -.
DR TreeFam; TF317299; -.
DR Proteomes; UP000002279; Chromosome 7.
DR Bgee; ENSOANG00000007275; Expressed in cerebellum and 2 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 4.10.320.30; -; 6.
DR InterPro; IPR013681; Myelin_TF.
DR InterPro; IPR002515; Znf_C2H2C.
DR InterPro; IPR036060; Znf_C2H2C_sf.
DR PANTHER; PTHR10816; MYELIN TRANSCRIPTION FACTOR 1-RELATED; 1.
DR PANTHER; PTHR10816:SF9; SUPPRESSION OF TUMORIGENICITY 18 PROTEIN; 1.
DR Pfam; PF08474; MYT1; 1.
DR Pfam; PF01530; zf-C2HC; 6.
DR SUPFAM; SSF103637; CCHHC domain; 6.
DR PROSITE; PS51802; ZF_CCHHC; 6.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01143}.
FT DOMAIN 487..725
FT /note="Myelin transcription factor 1"
FT /evidence="ECO:0000259|Pfam:PF08474"
FT REGION 103..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 177..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 629..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 686..718
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 936..998
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 192..220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..655
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 686..709
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1057 AA; 116442 MW; 3283708DA412E2A0 CRC64;
MDADGEDKKL RTRSKGSKVQ VDTLVKELSA ACSCPMAKKR RAEEQASGVP INKRKSLLMK
PRHYSPTVGC KEETEEQIEL EDDNSLLETN GHSISEESVR ISTNGPLHFS GQESSTRSQD
GYASYQDVEV KSRLMNLGKL EKDAAAQTVT ENLNDRGIQP LKTEIDSVDE CYLIRPPERR
GKMDDPCPPY GSSDDNESNS EVMENGWDTS STFSEETPVR PNAGQQYLQG GHQKDSLDIP
EIKSEGEKFL CRETVCDSKS ELRHSRDSHL ESFEKRVQNP FPECEEDDNE SLSVTTEESV
DLDKTKGNLT LLEQAIALQA EPSHGFHSTY KELDRFLLEH LVGERRQTKV MDIGGRQMYH
SKHSPRSEKR ETKCPIPGCD GTGHVTGLYP HHRSLSGCPH KVRVPLEILA MHENVLKCPT
PGCTGRGHVN SNRNTHRSLS GCPIAAAEKL AMSQDKNQLD SPKTGQCPDQ VHRTNLVKQL
ELSQFSFRSS QVVTSPRAHL TKEQEKFGKV PFDYASFDAQ VFGKHTLGPT VPGRKTPQYP
ESKHFSNPVK FSNRLPSASA HTQSPCHANS YSYGQCSEDT HIAAAAAILN LSTRCREAAE
ILSNKPQSLS AKGAEIEVDE NGTLDLSMKK NRVQEKATTL TPSDTSAPTP SSSPFKTSSI
LVNAAFYQAL CEQEGWDTPI NYSKTHAKKE EEKEKDATRS PENLEEKKYP GEVSIPSPKS
RIHARDLKKE LITCPTPGCD GSGHVTGNYA SHRSVSGCPL ADKTLKSLMA ANSQELKCPT
PGCDGSGHVT GNYASHRSLS GCPRARKGGI KVTPTKEDKE DPELKCPVIG CDGQGHISGK
YTSHRTASGC PLAAKRQKEN PLNGSSLSWK LNKQELPHCP LPGCNGLGHV NNVFVTHRSL
SGCPLNAQAI KKGKISEELM TIKLKASGGI ESDEEIRHLD EEIKELNESN LKIEADMMKL
QTQITSMESN LKTIEEENKL IEQNNESLLK ELAGLSQALI SSLADIQLPQ MGPISEQNFE
AYVSTLTDMY SNLERNYSPE CKALLESIKQ AVKGIHV
//
