ID F7CM56_ORNAN Unreviewed; 724 AA.
AC F7CM56;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Macrophage stimulating 1 {ECO:0000313|Ensembl:ENSOANP00000011368.2};
GN Name=MST1 {ECO:0000313|Ensembl:ENSOANP00000011368.2};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000011368.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000011368.2, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000011368.2,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000011368.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000011368.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S1 family. Plasminogen subfamily.
CC {ECO:0000256|PIRNR:PIRNR001152}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00121}.
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DR AlphaFoldDB; F7CM56; -.
DR STRING; 9258.ENSOANP00000011368; -.
DR Ensembl; ENSOANT00000011370.3; ENSOANP00000011368.2; ENSOANG00000007143.3.
DR eggNOG; ENOG502QRJ0; Eukaryota.
DR GeneTree; ENSGT00940000159461; -.
DR TreeFam; TF329901; -.
DR Proteomes; UP000002279; Chromosome X1.
DR Bgee; ENSOANG00000007143; Expressed in liver and 1 other cell type or tissue.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00108; KR; 4.
DR CDD; cd01099; PAN_AP_HGF; 1.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 1.
DR Gene3D; 2.40.20.10; Plasminogen Kringle 4; 4.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR024174; HGF/MST1.
DR InterPro; IPR000001; Kringle.
DR InterPro; IPR013806; Kringle-like.
DR InterPro; IPR018056; Kringle_CS.
DR InterPro; IPR038178; Kringle_sf.
DR InterPro; IPR003609; Pan_app.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR PANTHER; PTHR24261:SF12; HEPATOCYTE GROWTH FACTOR-LIKE PROTEIN-RELATED; 1.
DR PANTHER; PTHR24261; PLASMINOGEN-RELATED; 1.
DR Pfam; PF00051; Kringle; 4.
DR Pfam; PF00024; PAN_1; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PIRSF; PIRSF001152; HGF_MST1; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR PRINTS; PR00018; KRINGLE.
DR SMART; SM00130; KR; 4.
DR SMART; SM00473; PAN_AP; 1.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF57414; Hairpin loop containing domain-like; 1.
DR SUPFAM; SSF57440; Kringle-like; 4.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS00021; KRINGLE_1; 4.
DR PROSITE; PS50070; KRINGLE_2; 4.
DR PROSITE; PS50948; PAN; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00121};
KW Kringle {ECO:0000256|ARBA:ARBA00022572, ECO:0000256|PROSITE-
KW ProRule:PRU00121}; Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Serine protease homolog {ECO:0000256|PIRNR:PIRNR001152};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..724
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5028189114"
FT DOMAIN 20..106
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 110..187
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT DOMAIN 191..269
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT DOMAIN 298..377
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT DOMAIN 385..464
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT DOMAIN 497..722
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT DISULFID 192..269
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00121"
FT DISULFID 213..252
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00121"
FT DISULFID 241..264
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00121"
FT DISULFID 320..359
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00121"
FT DISULFID 348..371
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00121"
SQ SEQUENCE 724 AA; 82350 MW; BB8359F6AD16A08B CRC64;
MWRRVLALLV LPLVSPRTSV QRSPLNDFQL LKATELRFLS QQAPEPWQEN TVSLEECARR
CVRARTCRAF HYNLVSETCQ LLSQTQNSAH TLLQRNIHYD LFQKKDYVRE CIVERGATYR
GTVATTIEGH PCQPWKEKYP FDHKFVPTAH NGLEENYCRN PDGAQGGPWC YTQNPAVRSQ
VCGIKTCEEA TCLSCNGEDY RGSVDRTESG RECQRWDLQR PHKHPYDPNT YPDKNLDDNY
CRNPDGSERP WCYTTDREHP REFCHIPRCR SLPDYRSPAA AREKGARRWQ PPEDTTLTCF
RGKGEGYRGT ANTTVSGIPC QRWDAQTPHR HHFLPEKYQC KDLRENYCRN PDGSEGPWCF
TSRSSLHMGF CFQIKRCPDD VKVEDCYPGN GAQYRGRVNK TRKGIICQRW ADKTPHQPQF
SPTTAPHAHL EGNFCRNPDD DSHGPWCYTT DPNTPFDYCA LKPCDSNRKP SILETPDQVL
FEKCGKRDDR RQEKLRVIGG QPGNSPWTVS LRNRQGQHFC GGTLVSEQWV ISARQCFSSC
EATVRGYEAW LGTLFKNPGP NDPDLQVIPV VHLVCGPSNS QLVMLKLERP VTPSPRVAVI
CLPPEKYVVP KGTKCEIAGW GETQGTGNPN VLNVATLHVM SNRDCNVKHR GRVQETEMCT
EGLLAPAGAC EGDYGGPLAC FTHDCWVLEG IIIPNRVCAR PGWPAIFTRV SVYVDWIKKV
MKLT
//
