ID F7CNJ3_XENTR Unreviewed; 737 AA.
AC F7CNJ3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Sulfate transporter {ECO:0000313|Ensembl:ENSXETP00000044306, ECO:0000313|RefSeq:XP_012815261.1};
GN Name=slc26a2.2 {ECO:0000313|Ensembl:ENSXETP00000044306,
GN ECO:0000313|RefSeq:XP_012815261.1,
GN ECO:0000313|Xenbase:XB-GENE-1214887};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000044306};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000044306}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000044306};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000044306}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_012815261.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_012815261.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_012815261.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|RuleBase:RU362052}.
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DR RefSeq; XP_012815261.1; XM_012959807.2.
DR Ensembl; ENSXETT00000044306; ENSXETP00000044306; ENSXETG00000031991.
DR GeneID; 100494580; -.
DR KEGG; xtr:100494580; -.
DR CTD; 100494580; -.
DR Xenbase; XB-GENE-1214887; slc26a2.2.
DR eggNOG; KOG0236; Eukaryota.
DR HOGENOM; CLU_003182_9_4_1; -.
DR OMA; HYFDFER; -.
DR TreeFam; TF313784; -.
DR Proteomes; UP000008143; Chromosome 3.
DR Bgee; ENSXETG00000031991; Expressed in embryo.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0098661; P:inorganic anion transmembrane transport; IEA:UniProtKB-UniRule.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00815; sulP; 1.
DR PANTHER; PTHR11814:SF259; STAS DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 116..133
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 187..210
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 222..244
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 302..321
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 357..376
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 388..412
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 424..442
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 486..515
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 539..705
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 737 AA; 81571 MW; 145049F9686E22CB CRC64;
MDSSIINQDS EDTSKNEQTE QSSSLTFNYI HVKLEKHAQP EQSTKDIIVE KTREYCTSGP
KLLISILFRI FPVLQWFPRY KIKKYLPGDI TSGLIVGIVT IPQSIAYSVL ANQDPIYGLY
TNFFCCIIYF FMATSHHNCV GTFGVLCLMV GESVSKQLQA AGYNTDGTTT AAINSTLVGN
MTCDKSCYAI TVATSLTFIV GVYQILLGVF QLGFISMYLS EPLLSGFVTG SSLTILTSQM
KYLFGLKLTS RYGAGSLVLT WIDVFSNLKN TNICDLVTSI IAIAVIVPVK EINDRFKSKM
KIPCPVELIV IIVATLVSHY FDFHNNYKAS ICGTIPTGFK VPRAPNWGLI PSIAADAVPI
AIIGFAMTIS LAEIFAKKHG YTVSSNQEMI AIGTCNFITS FFSGFVSCAA LTKSLLREST
GANTQFNGII SSSVLLLVLL AIAPLFYSLQ NCVLGVITIT SLRGALRKFA DTPKMWRISK
IDTVVWWVSM LASSLITTEI GLLVAVCFSI LCVIFRTQRP RATLLAKVTG TEIYEDQFTY
KELSNIPNVK IYRFDASLYY ANKDYFKTTL YSKTDINPSL VSALQKKAKK EEEAAAIETK
NRFIARFNII KTSGKIRQSA SVSVPQFDIH SLIIDCGAMQ FIDTVGLGVL KEVKNDYEEI
GIRVFLANCN PSVRSMLSNG GYMNNASSGI DLHIFHSVHD AVNFAERKYR EKQRELQMND
AAFSFDPNQA ISDDLKD
//
