ID F7CQX0_HORSE Unreviewed; 1108 AA.
AC F7CQX0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Transmembrane protein 132C {ECO:0000313|Ensembl:ENSECAP00000005545.2};
GN Name=TMEM132C {ECO:0000313|Ensembl:ENSECAP00000005545.2,
GN ECO:0000313|VGNC:VGNC:50981};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000005545.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000005545.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000005545.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000005545.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000005545.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the TMEM132 family.
CC {ECO:0000256|ARBA:ARBA00006166}.
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DR AlphaFoldDB; F7CQX0; -.
DR STRING; 9796.ENSECAP00000005545; -.
DR PaxDb; 9796-ENSECAP00000005545; -.
DR Ensembl; ENSECAT00000007567.4; ENSECAP00000005545.2; ENSECAG00000007519.4.
DR VGNC; VGNC:50981; TMEM132C.
DR GeneTree; ENSGT00940000154702; -.
DR HOGENOM; CLU_009871_2_0_1; -.
DR InParanoid; F7CQX0; -.
DR OMA; DQWSISI; -.
DR OrthoDB; 3670111at2759; -.
DR TreeFam; TF314981; -.
DR Proteomes; UP000002281; Chromosome 8.
DR Bgee; ENSECAG00000007519; Expressed in chorionic villus and 13 other cell types or tissues.
DR ExpressionAtlas; F7CQX0; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR026307; TMEM132.
DR InterPro; IPR031436; TMEM132_C.
DR InterPro; IPR031437; TMEM132_M.
DR InterPro; IPR031435; TMEM132_N.
DR PANTHER; PTHR13388:SF4; TRANSMEMBRANE PROTEIN 132C; 1.
DR PANTHER; PTHR13388; UNCHARACTERIZED; 1.
DR Pfam; PF16070; TMEM132; 1.
DR Pfam; PF15706; TMEM132D_C; 1.
DR Pfam; PF15705; TMEM132D_N; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..1108
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018704849"
FT TRANSMEM 925..950
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 51..179
FT /note="Transmembrane protein TMEM132 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF15705"
FT DOMAIN 439..781
FT /note="Transmembrane protein family 132 middle"
FT /evidence="ECO:0000259|Pfam:PF16070"
FT DOMAIN 894..978
FT /note="Transmembrane protein TMEM132 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF15706"
FT REGION 799..858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 983..1052
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 803..855
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1023..1045
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1108 AA; 121057 MW; 577A5FBAFD60B4FA CRC64;
MRAEGAAPGP GAPLCGALSL VLGALLGKVI EGRGVTDNIQ RFSSLPPYLP VSYQVLRAET
SFLLREANQD VMRNSSRQTR VESFFTFKAK RPPVLNASYG PFSVEKVMPL DLMLTSNLLG
PTKKFHFNWK LKASILRDKI YLSRPKVQVL FHVVGRDWDD HSPAERLPCL RVFAFRETRE
VRGSCRLQGD LGLCVAELEL LAGWFSPPTV VAGRKKSGDP AEGSLVELYY TVQAGDERGD
CASGDVRKGN AIRPGKDGLE ETTSHLQRIG AVGLYRAQDS AQLSELRLDG NVVIWLPSRP
VKQGDVVTAY VTVASNSTVD LFILRAKVKK GVTILSAQPS EPRQWDVKQE MGNGGKHATT
TVVCQRLGPS ASNRSSSLFN EVVQMNFEIA SFSSLSGTQP ITWQVEYPRK GTTDIAVSEI
FISQKDLVGI VPLAMDTAIL NTAILTGKTV AMPIKVVSVE ENGVVTDISE AVECKSTDED
VIKVSDRCDY VFVNGKEMKG KVDTVVNFTY QHLSAPLHVT VWAPRLPLQI EVSDTELSQI
KGWRVPIVAS KRPTRESEDE DEEARRARGC ALQYQHATVR VLTQFVAEGA GPWGQPSHLL
SPDWQVDITH LVADFMKLEE PHVATLQDSR TLVGREVGMT TIQVLSPLSD SILAEKTVTV
LDDKVSVTDL AIQLVAGLSV TLHPSPENSK VITAVATAEE LLRTPKQEAV VSTWLQFSDG
SVTPLDIYDT TDFTLTATSL DEAVVSVPQA RSPRWPVVVA EGEGQGPLVR VDLTIAEACQ
KSKRKSVLAV GIGNVRVKFG QNDADPRPGR DYDEGEIKNH ASDRRQKGQD PERVGQDAHF
HGSSSVEREE GALRRGSTTA KSLLDNKVVK NSRLDGGRLA GEGQLQNIPI DFTNFPAQVD
LPQAGGGLGD SDLVQTPRGL SDLEIGMYAL LGVFCLAILV FLINCATFAL KYRHKQVPLE
GQASMTHSHD WVWLGNEAEL LENVGEGSPP QDEHTTIIDR GPGGCEESNR LLLNGGSQKH
VPSHPHRPAD SGGKQGRDQK HEPLHSPTSK RKKVKFTTFT TIPPDDSCPT VNSILGANEE
DIKWVCQDVD AGAPKELRNY LEKFKDKV
//
