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Database: UniProt
Entry: F7CV12_HORSE
LinkDB: F7CV12_HORSE
Original site: F7CV12_HORSE 
ID   F7CV12_HORSE            Unreviewed;       466 AA.
AC   F7CV12;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 2.
DT   05-JUN-2019, entry version 34.
DE   RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE            EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
DE   AltName: Full=Hyaluronoglucosaminidase {ECO:0000256|RuleBase:RU610713};
GN   Name=LOC106783049 {ECO:0000313|Ensembl:ENSECAP00000021018};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000021018, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000021018, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021018,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000021018}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021018};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-
CC         beta-D-glucosamine and D-glucuronate residues in hyaluronate.;
CC         EC=3.2.1.35; Evidence={ECO:0000256|RuleBase:RU610713};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC       {ECO:0000256|PIRNR:PIRNR038193, ECO:0000256|RuleBase:RU610713}.
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DR   Ensembl; ENSECAT00000025270; ENSECAP00000021018; ENSECAG00000023576.
DR   eggNOG; ENOG410IECJ; Eukaryota.
DR   eggNOG; ENOG410XPZT; LUCA.
DR   GeneTree; ENSGT00950000182708; -.
DR   Proteomes; UP000002281; Chromosome 4.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR018155; Hyaluronidase.
DR   PANTHER; PTHR11769; PTHR11769; 2.
DR   Pfam; PF01630; Glyco_hydro_56; 1.
DR   PIRSF; PIRSF038193; Hyaluronidase; 2.
DR   PRINTS; PR00846; GLHYDRLASE56.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR038193-3};
KW   Glycosidase {ECO:0000256|RuleBase:RU610713};
KW   Hydrolase {ECO:0000256|RuleBase:RU610713};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    466       Hyaluronidase. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5018711663.
FT   TRANSMEM    427    447       Helical. {ECO:0000256|SAM:Phobius}.
FT   ACT_SITE    135    135       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR038193-1}.
FT   CARBOHYD    327    327       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000256|PIRSR:PIRSR038193-2}.
FT   DISULFID     47    310       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    211    227       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    335    346       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    340    395       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    397    406       {ECO:0000256|PIRSR:PIRSR038193-3}.
SQ   SEQUENCE   466 AA;  54092 MW;  8C9DA6148CCB5F01 CRC64;
     MCNPLVGWLG MLLLLTVFTH SALKPAMPPV IKHQPFNIFW AAPTIQCEHF FNVDLNLPLF
     NILSNPLETQ SGSTIAIIYP NQLGYYPYFS QDGKSFNGGI PQNMSLSKHL RKTADDIAKI
     VPWWRSEGLV VIDWESWKPQ WDRNWGNRMI YKNYSLAFTR NHHPDWSEMK VKTVAQKEFE
     NAGRSFMNTT LALALEMRPK CLWGFYLYPD CYNYDYRINP QIYTGKCPND EIFHNDQLQW
     LWEKSTALYT SIYLDKILKS SLNALKFVHY RVREAMRVAE MATHDYVLPV FIFSRPFYLH
     SLEALSQEAC LSVQKSIQGP LGHYAVNVTS AAKLCSQSLC NNNGRCVRKT LESSSYLHMP
     ESSSKKYVLN KSFKFLISPV NKLKTIKDMK NAFVCHCYYG WHGESCQQRP PDLLRGKNKA
     SMANFNFSVF LSVPLSVILL NFFTPYYNVN FSLKYEREEN VDLFFL
//
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