ID F7CV41_ORNAN Unreviewed; 455 AA.
AC F7CV41;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Proteasome 26S subunit, non-ATPase 12 {ECO:0000313|Ensembl:ENSOANP00000012806.3};
GN Name=PSMD12 {ECO:0000313|Ensembl:ENSOANP00000012806.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000012806.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000012806.3, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000012806.3,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000012806.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000012806.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the proteasome subunit p55 family.
CC {ECO:0000256|ARBA:ARBA00006397}.
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DR AlphaFoldDB; F7CV41; -.
DR STRING; 9258.ENSOANP00000012806; -.
DR Ensembl; ENSOANT00000012808.3; ENSOANP00000012806.3; ENSOANG00000008054.3.
DR eggNOG; KOG1498; Eukaryota.
DR GeneTree; ENSGT00940000153510; -.
DR HOGENOM; CLU_033860_2_0_1; -.
DR InParanoid; F7CV41; -.
DR OMA; AENEMFK; -.
DR OrthoDB; 158659at2759; -.
DR TreeFam; TF105721; -.
DR Proteomes; UP000002279; Chromosome 15.
DR Bgee; ENSOANG00000008054; Expressed in fibroblast and 8 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IBA:GO_Central.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR040134; PSMD12/CSN4.
DR InterPro; IPR040896; RPN5_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10855:SF1; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12; 1.
DR PANTHER; PTHR10855; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4; 1.
DR Pfam; PF01399; PCI; 1.
DR Pfam; PF18098; RPN5_C; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Proteasome {ECO:0000256|ARBA:ARBA00022942};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT DOMAIN 241..419
FT /note="PCI"
FT /evidence="ECO:0000259|PROSITE:PS50250"
SQ SEQUENCE 455 AA; 52909 MW; 619945CF2FDD5F27 CRC64;
MADGAERADG RIVKMEVDYS ATVDQRLPEC EKLAKEGRLQ EVIETLLSLE KQTRTASDMV
STSRILVAVV KMCYEAKEWD FLNENIILLS KRRSQLKQAV AKMVQQCCTY VEEITDLPIK
LRLIDTLRMV TEGKIYVEIE RARLTKTLAA IKEQNGEVKE AASILQELQV ETYGSMEKKE
RVEFILEQMR LCLAVKDYIR TQIISKKINT KFFQEENTEK SKLKYYNLMI QLDQHEGSYL
SICKHYRAIY DTPCIQAESE KWQQALKSVV LYVILSPFDN EQSDLVHRIS SDKKLEEIPK
YKDLLKLFTT MELMRWTTLV EDYGKELREG SPGSPATDVF GYTEEGEKRW KDLKNRVVEH
NIRIMAKYYT RITMKRMAQL LDLSVDESEA FLSNLVVNKT IFAKVDRLAG IINFQRPKDP
NNLLNDWSQK LNSLMSLVNK TTHLIAKEEM IHNLQ
//
