ID F7CWX4_XENTR Unreviewed; 458 AA.
AC F7CWX4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=DENN domain-containing protein 2D isoform X1 {ECO:0000313|RefSeq:XP_012811355.1};
DE SubName: Full=DENN/MADD domain containing 2D {ECO:0000313|Ensembl:ENSXETP00000009561};
GN Name=dennd2d {ECO:0000313|Ensembl:ENSXETP00000009561,
GN ECO:0000313|RefSeq:XP_012811355.1,
GN ECO:0000313|Xenbase:XB-GENE-5816391};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000009561};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000009561}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000009561};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000009561}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_012811355.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_012811355.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_012811355.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_012811355.1; XM_012955901.3.
DR Ensembl; ENSXETT00000009561; ENSXETP00000009561; ENSXETG00000004388.
DR GeneID; 100145288; -.
DR AGR; Xenbase:XB-GENE-5816391; -.
DR CTD; 79961; -.
DR Xenbase; XB-GENE-5816391; dennd2d.
DR eggNOG; KOG3569; Eukaryota.
DR HOGENOM; CLU_008196_5_1_1; -.
DR OrthoDB; 5398783at2759; -.
DR TreeFam; TF320336; -.
DR Proteomes; UP000008143; Chromosome 2.
DR Bgee; ENSXETG00000004388; Expressed in egg cell and 9 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR15288; DENN DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR15288:SF2; DENN DOMAIN-CONTAINING PROTEIN 2D; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT DOMAIN 50..439
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
SQ SEQUENCE 458 AA; 52573 MW; 010FBCD0948D0DF0 CRC64;
MDQLAGVIRR SFRRKSNKRG SIHGASASED RSIPTDQKTL VLSGGQSFFE YLVVVSLKKN
YDGNYAPQIT YQFPKLENIL HFQKDEEERL LNAIPLFCFP DGNTWAPLKE YTSETFSFVL
TNIDSSRKFG YCRRLLPAGN GSHSPEVYCI ISSLGCFGLF AKILDEVEKR REIATALIYP
FMQGLREATF PAPGKTVKIK SFIPESGTEI IELTRPLDCR LEHIDFKTLL QCLNSQIILH
IFASVVLERR VILVARDLSI LSECIHAVVA LLYPFAWEHT YIPVLPHVLI DTVSCPAPFI
VGVQNQFLSH ILDQPMEEVL LVDLCKGELI QKVGDEEKIL PPKLQEQIRI SLDDYQQITK
TTPEINTAVS KTFMQFFMKV MGHYTSHLQE INVGKFTFQE KAFLKAIHSK TIRRFLKCFV
KTQMFSIFIE AQQNKSTQNV YFQQKVKEFN EQRKPERK
//
