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Database: UniProt
Entry: F7CZL9_MONDO
LinkDB: F7CZL9_MONDO
Original site: F7CZL9_MONDO 
ID   F7CZL9_MONDO            Unreviewed;       860 AA.
AC   F7CZL9;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   12-SEP-2018, entry version 44.
DE   SubName: Full=Transient receptor potential cation channel subfamily C member 7 {ECO:0000313|Ensembl:ENSMODP00000018922};
GN   Name=TRPC7 {ECO:0000313|Ensembl:ENSMODP00000018922};
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000018922, ECO:0000313|Proteomes:UP000002280};
RN   [1] {ECO:0000313|Ensembl:ENSMODP00000018922, ECO:0000313|Proteomes:UP000002280}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17495919; DOI=10.1038/nature05805;
RA   Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L.,
RA   Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J.,
RA   Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A.,
RA   Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L.,
RA   Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M.,
RA   Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E.,
RA   Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M.,
RA   Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E.,
RA   Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A.,
RA   Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J.,
RA   Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J.,
RA   Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S.,
RA   Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A.,
RA   Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C.,
RA   Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P.,
RA   Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C.,
RA   Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K.,
RA   Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D.,
RA   Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G.,
RA   Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E.,
RA   Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C.,
RA   Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E.,
RA   Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K.,
RA   Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A.,
RA   Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R.,
RA   Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A.,
RA   Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N.,
RA   Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S.,
RA   Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F.,
RA   Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P.,
RA   Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D.,
RA   Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA   Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT   "Genome of the marsupial Monodelphis domestica reveals innovation in
RT   non-coding sequences.";
RL   Nature 447:167-177(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMODP00000018922}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS01006510}.
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DR   STRING; 13616.ENSMODP00000018922; -.
DR   Ensembl; ENSMODT00000019264; ENSMODP00000018922; ENSMODG00000015142.
DR   eggNOG; KOG3609; Eukaryota.
DR   eggNOG; ENOG410XQ0Y; LUCA.
DR   GeneTree; ENSGT00760000119180; -.
DR   InParanoid; F7CZL9; -.
DR   OrthoDB; EOG091G01FB; -.
DR   TreeFam; TF313147; -.
DR   Proteomes; UP000002280; Chromosome 1.
DR   Bgee; ENSMODG00000015142; Expressed in 2 organ(s), highest expression level in testis.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0015279; F:store-operated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0006828; P:manganese ion transport; IBA:GO_Central.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   GO; GO:0007338; P:single fertilization; IBA:GO_Central.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR004729; TRP_channel.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR005463; TRPC7_channel.
DR   InterPro; IPR002153; TRPC_channel.
DR   PANTHER; PTHR10117; PTHR10117; 1.
DR   PANTHER; PTHR10117:SF9; PTHR10117:SF9; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
DR   PRINTS; PR01648; TRPCHANNEL7.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   TIGRFAMs; TIGR00870; trp; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|SAAS:SAAS00933366};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002280};
KW   Ion channel {ECO:0000256|SAAS:SAAS00790162};
KW   Ion transport {ECO:0000256|SAAS:SAAS00790154};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW   Repeat {ECO:0000256|SAAS:SAAS00931009};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00788392}.
FT   TRANSMEM    351    371       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    383    403       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    472    493       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    578    601       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    621    637       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    649    671       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       50    127       ANK_REP_REGION. {ECO:0000259|Pfam:
FT                                PF12796}.
FT   DOMAIN      197    259       TRP_2. {ECO:0000259|Pfam:PF08344}.
FT   DOMAIN      391    682       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      808    828       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   860 AA;  99214 MW;  14398FEEB7B9BEA4 CRC64;
     LENSNFKSMH RRHTTLREKG RRQAIRGPAY MFNEKGTSLT MEEERFLDSA EYGNIPVVRK
     MLEESKTLNF NCVDYMGQNA LQLAVGNEHL EVTELLLKKE NLARVGDALL LAISKGYVRI
     VEAILNHPAF SQGQRLTLSP LEQELRDDDF YAYDEDGTRF SHDITPIILA AHCQEYEIVH
     ILLLKGARIE RPHDYFCKCN ECAEKQRKDS FSHSRSRMNA YKGLASAAYL SLSSEDPVLT
     ALELSNELAR LANIETEFKN DYRKLSMQCK DFVVGVLDLC RDTEEVEAIL NGDVNIQVWA
     DYHRPSLSRI KLAIKYEVKK FVAHPNCQQQ LLTMWYENLS GLRQQSIAVK FLAVFGISIG
     LPFLAIAYWI APCSKLGWIL RSPFMKFVAH AVSFTIFLGL LVLNASDRFE GVKNLPNETI
     TDYPKQIFRV KTTQFSWTEM LIMKWVLGMI WSECKEIWEE GPREYVMHLW NLLDFGMLSI
     FVASFTARFM AFLKASEAQM YVDQYVQDDN LNNVTLPPEV AYFTFARNKW RPSDPQIISE
     GLYAIAVVLS FSRIAYILPA NESFGPLQIS LGRTVKDIFK FMVIFIMVFV AFMIGMFNLY
     SYYLGAKYNP AFTTVEESFK TLFWSIFGLS EVISVVLKYN HKFIENIGYV LYGVYNVTMV
     VVLLNMLIAM INNSYQEIEE DADVEWKFAR AKLWLSYFDE GRTLPAPFNL VPSPKSFYYL
     IMRIKMCLIK LCKSKAKSCE NDLEMGMLNS KLRKSRYQTS MGNADNLTVK NTFSKPTRYQ
     KIMKRLIKRY VLKAQVDREN DEVNEGELKE IKQDISSLRY ELLEEKSQAT GELAGLIQQL
     SDKFGKNLNK DHLMMNKGKD
//
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