ID F7D0D4_MOUSE Unreviewed; 203 AA.
AC F7D0D4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Dynein, axonemal, heavy chain 12 {ECO:0000313|Ensembl:ENSMUSP00000073035.5};
GN Name=Dnah12 {ECO:0000313|Ensembl:ENSMUSP00000073035.5,
GN ECO:0000313|MGI:MGI:107720};
GN Synonyms=Dnahc12 {ECO:0000313|MGI:MGI:107720};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000073035.5, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000073035.5, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000073035.5,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000073035.5}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000073035.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F7D0D4; -.
DR SMR; F7D0D4; -.
DR ProteomicsDB; 349476; -.
DR Antibodypedia; 48520; 84 antibodies from 14 providers.
DR Ensembl; ENSMUST00000073309.5; ENSMUSP00000073035.5; ENSMUSG00000021879.14.
DR UCSC; uc007std.1; mouse.
DR AGR; MGI:107720; -.
DR MGI; MGI:107720; Dnah12.
DR VEuPathDB; HostDB:ENSMUSG00000021879; -.
DR GeneTree; ENSGT00940000154280; -.
DR HOGENOM; CLU_041873_2_0_1; -.
DR OMA; CIEWQRY; -.
DR PhylomeDB; F7D0D4; -.
DR ChiTaRS; Dnah12; mouse.
DR Proteomes; UP000000589; Chromosome 14.
DR Bgee; ENSMUSG00000021879; Expressed in spermatocyte and 28 other cell types or tissues.
DR ExpressionAtlas; F7D0D4; baseline and differential.
DR GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|ProteomicsDB:F7D0D4};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 1..203
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
SQ SEQUENCE 203 AA; 22445 MW; 2E114B5CF87E8F22 CRC64;
VITPLTDRCY RTLIGAFYLN LGGAPEGPAG TGKTETTKDL AKALAVQCVV FNCSDGLDYL
AMGKFFKGLA SSGAWACFDE FNRIELEVLS VVAQQILCIQ RAIQQKLEAF VFEGTELRLN
PNCFVAITMN PGYAGRSELP DNLKVLFRTV AMMVPNYALI AEISLYSYGF LNAKPLSVKI
VMTYRLCSEQ LSSQFHYDYG MRA
//
