ID F7D0L9_XENTR Unreviewed; 350 AA.
AC F7D0L9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Major histocompatibility complex class I antigen {ECO:0000313|Ensembl:ENSXETP00000037199};
GN Name=mhc1a {ECO:0000313|Ensembl:ENSXETP00000037199};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000037199};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000037199}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000037199};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000037199}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MHC class I family.
CC {ECO:0000256|RuleBase:RU004439}.
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DR AlphaFoldDB; F7D0L9; -.
DR Ensembl; ENSXETT00000037199; ENSXETP00000037199; ENSXETG00000017065.
DR Xenbase; XB-GENE-485307; mhc1a.
DR eggNOG; ENOG502RQEK; Eukaryota.
DR HOGENOM; CLU_047501_0_1_1; -.
DR InParanoid; F7D0L9; -.
DR TreeFam; TF352056; -.
DR Bgee; ENSXETG00000017065; Expressed in digestive system element and 29 other cell types or tissues.
DR ExpressionAtlas; F7D0L9; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd21029; IgC1_CD1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011161; MHC_I-like_Ag-recog.
DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR001039; MHC_I_a_a1/a2.
DR PANTHER; PTHR16675:SF235; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DP BETA 1 CHAIN-LIKE [PROVISIONAL]; 1.
DR PANTHER; PTHR16675; MHC CLASS I-RELATED; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00129; MHC_I; 1.
DR PRINTS; PR01638; MHCCLASSI.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..350
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030169971"
FT TRANSMEM 301..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 203..289
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 350 AA; 39925 MW; A56955F0495C8103 CRC64;
MDVRLVPLLL TLGVSAVYSG SHSLRYYYTA VSDRAFGLPE FSTAGYVDET QIERYSSDNG
KSEPAAQWMK QNEGPEYRDE QTQILKGNEA VFKHNVKVAM DRFNQTSGTH IVQSMYGCEL
REDGSTRGYE QDGYDGREFL ALDTERWVYV PSMREAQLTT QKWNSPEVNE PERERNYLEN
ICIEWLKRYL GYGQAELERR VRPHVKISDR QSDGNTELHC QAYGFYPREI DVKWVRNGKD
DVHSEEAKEI LPNPDGSYQL RVTAEVTPKE GDSYACHVEH SSLEEKLIVV WPGPNKDGKN
MVIIIAGVVV AVLLITAAVV GFAFYKKRKA KSGYTDLQTK IKSLPHTSIY
//
