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Database: UniProt
Entry: F7D4E7_HORSE
LinkDB: F7D4E7_HORSE
Original site: F7D4E7_HORSE 
ID   F7D4E7_HORSE            Unreviewed;       709 AA.
AC   F7D4E7;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   10-OCT-2018, entry version 40.
DE   SubName: Full=Transglutaminase 7 {ECO:0000313|Ensembl:ENSECAP00000000304};
GN   Name=TGM7 {ECO:0000313|VGNC:VGNC:24065};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000000304, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000000304, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000000304,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000000304}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000000304};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000459-2};
CC       Note=Binds 1 Ca(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR000459-2};
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DR   STRING; 9796.ENSECAP00000000304; -.
DR   PaxDb; F7D4E7; -.
DR   Ensembl; ENSECAT00000000390; ENSECAP00000000304; ENSECAG00000000416.
DR   VGNC; VGNC:24065; TGM7.
DR   eggNOG; ENOG410IFMV; Eukaryota.
DR   eggNOG; ENOG410XQEZ; LUCA.
DR   GeneTree; ENSGT00760000119108; -.
DR   InParanoid; F7D4E7; -.
DR   OMA; MKASRKM; -.
DR   OrthoDB; EOG091G030K; -.
DR   TreeFam; TF324278; -.
DR   Proteomes; UP000002281; Chromosome 1.
DR   Bgee; ENSECAG00000000416; Expressed in 2 organ(s), highest expression level in liver.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:InterPro.
DR   GO; GO:0018149; P:peptide cross-linking; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 3.
DR   Gene3D; 3.90.260.10; -; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR038765; Papain_like_cys_pep_sf.
DR   InterPro; IPR002931; Transglutaminase-like.
DR   InterPro; IPR036985; Transglutaminase-like_sf.
DR   InterPro; IPR023608; Transglutaminase_animal.
DR   InterPro; IPR013808; Transglutaminase_AS.
DR   InterPro; IPR008958; Transglutaminase_C.
DR   InterPro; IPR036238; Transglutaminase_C_sf.
DR   InterPro; IPR001102; Transglutaminase_N.
DR   Pfam; PF00927; Transglut_C; 1.
DR   Pfam; PF01841; Transglut_core; 1.
DR   Pfam; PF00868; Transglut_N; 1.
DR   PIRSF; PIRSF000459; TGM_EBP42; 1.
DR   SMART; SM00460; TGc; 1.
DR   SUPFAM; SSF49309; SSF49309; 2.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   PROSITE; PS00547; TRANSGLUTAMINASES; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PIRSR:PIRSR000459-2};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000459-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT   DOMAIN      270    363       TGc. {ECO:0000259|SMART:SM00460}.
FT   ACT_SITE    278    278       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   ACT_SITE    337    337       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   ACT_SITE    360    360       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   METAL       400    400       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
FT   METAL       402    402       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
FT   METAL       449    449       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
FT   METAL       454    454       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
SQ   SEQUENCE   709 AA;  79284 MW;  86079370BEC511BC CRC64;
     PPVAALELRS VDLQSSRNNK EHHTQEMGLK RLIVRRGQLF TLQLHFNRPF QFQTDHITFV
     AETGPAPMEL LGTRAIFSLT QARQGNVWSA SDFTIDSDSL FVSLFTPANA VIGSYTLKIE
     ISQGQGHSST HPLGTFILLF NPWSAEDDVH LPSEALLREY ILTDYGFVYK GQKRLITARP
     WNYGQFEEDI IDICFEILNK SLYFLKNPSK DCSQRNDVVY VCRVVSAMIN SNDDRGVLQG
     NWGEDYSMGV SPLEWNGSVA ILRQWSARGG QPVMYGQCWV FAAVMCTVMR CLGVPTRVVS
     NFRSAHNADG NLTIDTYYNR NAEMLPNQKQ DKIWNFHVWN ECWMIRKDLP PGYNGWQVLD
     PTPQQTSSGL FCCGPASVKA IKEGEVQLPY DTPFVYAEVN ADEVIWLFGD GQAQEILAHN
     TSSIGNEIST KMVGSDQRQN ITSSYKYPEG SPEERSVFMK ASQKMLGPGR ASSPFLDLLG
     SGDFQDQPAQ LQLHLARMPE WGRDLLLKLH ARRVADRAHP RAPIRLEVRF CAQALLHKGG
     AREPLWRQTV HLNLDFGQEI EWPLLLPFNN YGNKLTDEKL IRVSGIAKVK ETGRSMLVLK
     DISLEPPHLS IKASERAEVG KALGVHITLT NNLTVALSNC VMVLEGSGLI DGQISNELGT
     LLPGHTIQIQ LDLYPIKAGP RQLQVLISSN EVKEIKGYQD IFVAAAGAS
//
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