ID F7D4R2_HORSE Unreviewed; 1674 AA.
AC F7D4R2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 4.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Sialic acid binding Ig like lectin 1 {ECO:0000313|Ensembl:ENSECAP00000012038.4};
GN Name=SIGLEC1 {ECO:0000313|Ensembl:ENSECAP00000012038.4,
GN ECO:0000313|VGNC:VGNC:22977};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000012038.4, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000012038.4, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000012038.4,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000012038.4}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000012038.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 9796.ENSECAP00000012038; -.
DR PaxDb; 9796-ENSECAP00000012038; -.
DR Ensembl; ENSECAT00000015016.4; ENSECAP00000012038.4; ENSECAG00000014218.4.
DR VGNC; VGNC:22977; SIGLEC1.
DR GeneTree; ENSGT01100000263535; -.
DR InParanoid; F7D4R2; -.
DR Proteomes; UP000002281; Chromosome 22.
DR Bgee; ENSECAG00000014218; Expressed in synovial membrane of synovial joint and 23 other cell types or tissues.
DR ExpressionAtlas; F7D4R2; baseline.
DR GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR GO; GO:0005770; C:late endosome; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0046790; F:virion binding; IBA:GO_Central.
DR GO; GO:0075512; P:clathrin-dependent endocytosis of virus by host cell; IBA:GO_Central.
DR CDD; cd00096; Ig; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 17.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR47243; SIALOADHESIN; 1.
DR PANTHER; PTHR47243:SF1; SIALOADHESIN; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF13895; Ig_2; 6.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 17.
DR SMART; SM00408; IGc2; 14.
DR SUPFAM; SSF48726; Immunoglobulin; 11.
DR PROSITE; PS50835; IG_LIKE; 15.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1674
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040287253"
FT TRANSMEM 1639..1660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 139..233
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 238..320
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 322..409
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 411..507
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 511..593
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 601..701
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 704..781
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 795..888
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 894..973
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 980..1079
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1081..1161
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1168..1253
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1255..1337
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1440..1519
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1533..1622
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 1674 AA; 178826 MW; B24039C4EDE8964A CRC64;
MGFLLHLLHL TLSIPAGLAS WGVSSPQEVQ GVKGSCLLIP CVFTFPDRVE VPNGITSIWY
YDYSSSRKVA SHSAKPELVE SRFHGRTQLV GDAEDKVCNL LLKDLQLEDS GSYNYRFEIS
EGNRWSDVKG TVVTVTEKPS VPTIDAPAEL REGLEVDFNC STPYACPQGT ISLKWHGQDP
ARSVTSNLLK LEPTGIKHLE TLHMALSWQD HGRTLSCQLS VANHRIESKV HLQVQYAPKG
VDIVLSPSGR NILPGDRVTL TCRVNSSYPE VSSVQWVKDG MQLKAQSHVL QLSQAGWDDA
GVYTCQAENG VGSSVSPPVS LPVFMAKVQV SPAGPILENQ TVTLACNTPK EVAGELRYNW
YKNHAPLEDA HSQTLQLRPA TRADTGFYFC EVQNALGRER SGPVSMVVSH PPLALDLTAF
LETQAGQVGI FHCSVLSEPL ATLVLSHGGL VLASTLGEGD NSPRFSVSSA PNFLRLKIRD
LGPADSGEYT CSATNSFGNA SSTLDFHANA ARLLISPAAE VVEGQAVTLN CRSGLSPTPD
IRFSWYLNGA LLLEGPSSSL LLPAASSSDA GSYHCRAQDS HSASGPSLPA VLTVLYAPRQ
PTFTARLESD ATGVGAGRRG LLLCRVDSDP PAQLQLLHRD HVVASSHGCS TCGGCSPRTK
VTRAPNLLRV EIHDPGLEDE GVYLCEARNA LGNASASATF NAQATVLVIA PSHTLQEGTG
ANLTCNVSRE TDSGPANFSW FRNGALWAQG PLETMTLLPV ARTDAALYAC RILTEADAQL
SAPVLLSVLY PPDPPKLSAL LDMGQGHMAV FVCTVDSRPL AQLALFHGER LLATSPGPQL
PRHGRLQAKA TANALQLEVR DLGLGDSGSY RCEATNDLGS ANTSLFFQVR GAWVQVSPSP
ELQEGQAVVL SCQVPTGVLE GTSYRWYRDG QLLQEVTSAT LRFAAITLSQ AGAYHCQAQA
PGSATTSLAA PVSLHVSYAP RQAILTTLMD TGPGRQGLLL CRVNSDPPAQ LRLLHGDRLV
ASTLGGVEEL AGSSPRLQVA VAPNTLRLEI HNAVLEDEGV YTCEATNALG QVLASANFDA
QAVSVQVWPK ATVQEGQLVN LTCLVWTTRL AELTYMWYQD GQQRPGAHSI LLPNVTVTDA
ATYRCGLLTP GQAPRLSTPV TLDVLYAPRS LHLTYLLESR GGQLALILCT VDSRPPAQLA
LSRAGHLLAS STAASVPNTL RLELWEPRPS DEGLYSCSAH SPLGQANASL ELRLEAVQVT
LAPSATVPEG TPVTVTCEDT AARPPTLYTW YHNSRWLQEG PATSLSLPVA TRAHAGAYSC
QVQDAQGTRS SRPASLKVLY APRDAVVSSF WDSRAGPMAV VQCTVDSEPP AELALSHDGK
VLATTNGVHG LASETGHVQV ARNVLRLQVQ GVPLGDEDIY VCTAHNLLGS VSTTGQLKGE
GVHVVAEPGL DVPEGAALNL SCSLPGDPGP TGNSTFTWFW NGRRLHMETV PTLTFIHVAR
AQAGVYHCQA ELPSGATTST PVMLRVLYPP KTPTMTVFVE PEGGVQGILD CRVDSEPPAS
LTLHLGSRLV ASSQSRGAPA ETHLHISATP NALRVDIKEL RPSDQGEYVC SASNALGSAS
ASTYFGTRAL HRLRLFQQLL WVMGLLVLFL LLGLGACYTW RRRKLPESVM TQAL
//
