ID F7D4S7_XENTR Unreviewed; 727 AA.
AC F7D4S7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Dipeptidyl aminopeptidase-like protein 6 {ECO:0000256|ARBA:ARBA00040948};
DE AltName: Full=Dipeptidyl peptidase 6 {ECO:0000256|ARBA:ARBA00042016};
DE AltName: Full=Dipeptidyl peptidase VI {ECO:0000256|ARBA:ARBA00041991};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000020999};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000020999}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000020999};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000020999}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
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DR AlphaFoldDB; F7D4S7; -.
DR Ensembl; ENSXETT00000020999; ENSXETP00000020999; ENSXETG00000009512.
DR eggNOG; KOG2100; Eukaryota.
DR HOGENOM; CLU_006105_4_1_1; -.
DR InParanoid; F7D4S7; -.
DR TreeFam; TF313309; -.
DR Bgee; ENSXETG00000009512; Expressed in ovary and 1 other cell type or tissue.
DR ExpressionAtlas; F7D4S7; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002469; Peptidase_S9B_N.
DR PANTHER; PTHR11731:SF20; DIPEPTIDYL AMINOPEPTIDASE-LIKE PROTEIN 6; 1.
DR PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR Pfam; PF00930; DPPIV_N; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 28..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 126..488
FT /note="Dipeptidylpeptidase IV N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00930"
FT DOMAIN 570..722
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
SQ SEQUENCE 727 AA; 81611 MW; 69190E813ED1C2E5 CRC64;
MIVSTQQNLG TDLDIGGSDA PPRNWRGIGL AVLVITIVMS LVLLSIFLLS PEDPKQPVKP
FLTLSDLETM EYQVHVPTLS WASDTEIILK TRDGNLIQQN VKTKEFRILL RNTTLVSLRA
SNAELSPDLQ NILLIFNKQQ ISGVAAKASY SIYNIRTSEV WDLKPPGKNE TSLQYASWGP
HGSQVVFIFQ NDIYYQQSAS APALRLTSSG DPETVLNGIT DWTYQEEVLH SYAAHWWSPD
GTRLAYLSIN NTLVPKMELT YFLGSDYPAS RKYAYPKAGQ HIPTVKVLVV NLYGPSHTLE
LLLPDTFQYR EFYITMVIWV TNTRLAVKWL NRSQNLSVLT FCDATTGACI EKYRSLSDVW
ITIQGETLFS SEAAFFPVSV KQGASGEFLH VAMLSTQAGS METSLRILTS GNWDVTKVVA
YNPENKTVYF LSTEDMPRRR HLYSVETSGT LNRTCVSCDL IPDCHFVDAE FSPGSSYFIL
YCKGPGVPQV SVHQTQNPQD FIILEENKIL KASLNKNDMP ETVYKKIHIE GYDFPLRLTL
PSNYENSEFP LVLWLPEVPG YQQVTEEFSL GWESALVSSF QIILAHIDGK GSRNQGLHLL
HETDRRLGSI EMKDYIPIVQ HLKQLPFVDK YRIGVFGKAY GGFLALKLLS LPEQLFACGV
VVSPITSFHL HSAVVSERYL GLPSQEASAY TMASVLNDVQ RLQEQHFLLV HGTADGEITI
HELHSCM
//
