ID F7D5D9_HORSE Unreviewed; 331 AA.
AC F7D5D9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 {ECO:0000256|ARBA:ARBA00015852};
DE AltName: Full=Multisynthase complex auxiliary component p38 {ECO:0000256|ARBA:ARBA00032155};
DE AltName: Full=Protein JTV-1 {ECO:0000256|ARBA:ARBA00031241};
GN Name=AIMP2 {ECO:0000313|Ensembl:ENSECAP00000000041.3,
GN ECO:0000313|VGNC:VGNC:15189};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000000041.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000000041.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000000041.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000000041.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000000041.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; F7D5D9; -.
DR STRING; 9796.ENSECAP00000000041; -.
DR PaxDb; 9796-ENSECAP00000000041; -.
DR Ensembl; ENSECAT00000000055.4; ENSECAP00000000041.3; ENSECAG00000000053.4.
DR VGNC; VGNC:15189; AIMP2.
DR GeneTree; ENSGT00390000015826; -.
DR HOGENOM; CLU_076114_0_0_1; -.
DR InParanoid; F7D5D9; -.
DR OMA; LCQHYRV; -.
DR OrthoDB; 4146269at2759; -.
DR TreeFam; TF326322; -.
DR Proteomes; UP000002281; Chromosome 13.
DR Bgee; ENSECAG00000000053; Expressed in trophectoderm and 23 other cell types or tissues.
DR ExpressionAtlas; F7D5D9; baseline.
DR GO; GO:0017101; C:aminoacyl-tRNA synthetase multienzyme complex; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:Ensembl.
DR GO; GO:0065003; P:protein-containing complex assembly; IEA:Ensembl.
DR GO; GO:0060510; P:type II pneumocyte differentiation; IEA:Ensembl.
DR CDD; cd03200; GST_C_AIMP2; 1.
DR Gene3D; 1.20.1050.130; -; 1.
DR InterPro; IPR042360; AIMP2.
DR InterPro; IPR031889; AIMP2_LysRS-bd.
DR InterPro; IPR041503; AIMP2_thioredoxin.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR004046; GST_C.
DR PANTHER; PTHR13438; AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN; 1.
DR PANTHER; PTHR13438:SF2; AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 2; 1.
DR Pfam; PF16780; AIMP2_LysRS_bd; 1.
DR Pfam; PF00043; GST_C; 1.
DR Pfam; PF18569; Thioredoxin_16; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
PE 1: Evidence at protein level;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F7D5D9};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 1..44
FT /note="AIMP2 lysyl-tRNA synthetase binding"
FT /evidence="ECO:0000259|Pfam:PF16780"
FT DOMAIN 117..207
FT /note="AIMP2 thioredoxin-like"
FT /evidence="ECO:0000259|Pfam:PF18569"
FT DOMAIN 244..307
FT /note="Glutathione S-transferase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00043"
SQ SEQUENCE 331 AA; 36454 MW; ABE1A9F87C7F63D4 CRC64;
MPMYQVKPYH EGSASLRVEL PTCMYRLPNV HGRTGSPAPD VGHVQASDPS LQALESRQDD
ILKRLYELKA AVDGLSKMIQ TPDADLDVTN IIQADEPTVL STNAVDLNSV LGKDYGALKD
IVINANPASP PLSLLVLHQL LCDHYRVLST VHTHSALKSV PENLLKCFGE QTRKQPRHEY
QLGFTLIWKN VPKTQMKFSV QTMCPIEGEG NIARFLFSLF GQKHNAVNLT LIDSWVDIAI
LQLKEGSSKE KAAVFRSMNS ALGKSPWLVG NELTVADVVL WSVLQQTGGC SGTAPANVEK
WMRACENLAP FNTALRLLKG LSVTDFKGFS F
//
