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Database: UniProt
Entry: F7D6C0_XENTR
LinkDB: F7D6C0_XENTR
Original site: F7D6C0_XENTR 
ID   F7D6C0_XENTR            Unreviewed;       394 AA.
AC   F7D6C0;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 3.
DT   24-JAN-2024, entry version 75.
DE   SubName: Full=ATP-sensitive inward rectifier potassium channel 11 {ECO:0000313|RefSeq:XP_004916335.1};
DE   SubName: Full=Potassium inwardly rectifying channel subfamily J member 11 {ECO:0000313|Ensembl:ENSXETP00000006245};
GN   Name=kcnj11 {ECO:0000313|Ensembl:ENSXETP00000006245,
GN   ECO:0000313|RefSeq:XP_004916335.1,
GN   ECO:0000313|Xenbase:XB-GENE-6084577};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000006245};
RN   [1] {ECO:0000313|Ensembl:ENSXETP00000006245}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000006245};
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [2] {ECO:0000313|Ensembl:ENSXETP00000006245}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
RN   [3] {ECO:0000313|RefSeq:XP_004916335.1}
RP   IDENTIFICATION.
RC   STRAIN=Nigerian {ECO:0000313|RefSeq:XP_004916335.1};
RC   TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_004916335.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU003822}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel (TC
CC       1.A.2.1) family. {ECO:0000256|RuleBase:RU003822}.
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DR   RefSeq; XP_004916335.1; XM_004916278.4.
DR   Ensembl; ENSXETT00000006245; ENSXETP00000006245; ENSXETG00000002854.
DR   GeneID; 100492679; -.
DR   KEGG; xtr:100492679; -.
DR   CTD; 3767; -.
DR   Xenbase; XB-GENE-6084577; kcnj11.
DR   eggNOG; KOG3827; Eukaryota.
DR   HOGENOM; CLU_022738_4_0_1; -.
DR   OMA; QPWYAQS; -.
DR   OrthoDB; 4126787at2759; -.
DR   TreeFam; TF313676; -.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Bgee; ENSXETG00000002854; Expressed in brain and 1 other cell type or tissue.
DR   GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 2.60.40.1400; G protein-activated inward rectifier potassium channel 1; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; INWARD RECTIFIER POTASSIUM CHANNEL; 1.
DR   PANTHER; PTHR11767:SF55; KIR6.3 PROTEIN; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU003822};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU003822};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|ARBA:ARBA00022958, ECO:0000256|RuleBase:RU003822};
KW   Potassium transport {ECO:0000256|ARBA:ARBA00022538,
KW   ECO:0000256|RuleBase:RU003822};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003822};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003822};
KW   Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW   ECO:0000256|RuleBase:RU003822}.
FT   TRANSMEM        73..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        145..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          37..174
FT                   /note="Potassium channel inwardly rectifying transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF01007"
FT   DOMAIN          182..351
FT                   /note="Inward rectifier potassium channel C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF17655"
FT   REGION          355..394
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            161
FT                   /note="Role in the control of polyamine-mediated channel
FT                   gating and in the blocking by intracellular magnesium"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005465-1"
SQ   SEQUENCE   394 AA;  43955 MW;  F135787F75ADAD1D CRC64;
     MLARKGLLPD EFLITRLAED RASHSQYKLK TRRARFVAKN GACNVAHKNI REQGRFLQDV
     FTTMVDLKWH HSLLIFTMTF ICSWMLFAMA WWLIAFAHGD LGPKRGSFVP CVTNIQSFTS
     AFLFSIEVQV TIGFGGRMVT EQCPLAITVL IIQNISGLII NAVMLGCIFM KTAQANRRAE
     TLIFSKHAVI ACRDGKYRLM FRVGDLRKSM IISASIKIQI VKKTTTAEGE VVPISQVDIQ
     VENPVGTNSI FLVSPLIVSH TIDERSPLYT FSAYDLCNED LEVVAILEGV VETTGITTQA
     RTSYLPDEIL WGHRFVPIVT EEEGRYSVDY SKFGNTVKVN GPLCSPKDLA EGRYCGLPRN
     GQHSKPKKRR GESHGAGEAG REIAAENQFI DSDS
//
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