ID F7D8H4_ORNAN Unreviewed; 3622 AA.
AC F7D8H4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Cubilin {ECO:0008006|Google:ProtNLM};
GN Name=CUBN {ECO:0000313|Ensembl:ENSOANP00000011110.2};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000011110.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000011110.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000011110.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 9258.ENSOANP00000011110; -.
DR Ensembl; ENSOANT00000011112.2; ENSOANP00000011110.2; ENSOANG00000006974.2.
DR eggNOG; KOG4292; Eukaryota.
DR GeneTree; ENSGT00940000158291; -.
DR HOGENOM; CLU_000172_1_0_1; -.
DR InParanoid; F7D8H4; -.
DR OMA; RGFTVRW; -.
DR TreeFam; TF316506; -.
DR Proteomes; UP000002279; Unplaced.
DR Bgee; ENSOANG00000006974; Expressed in adult mammalian kidney and 6 other cell types or tissues.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd00041; CUB; 27.
DR CDD; cd00054; EGF_CA; 5.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 27.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR24251:SF37; CUB DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24251; OVOCHYMASE-RELATED; 1.
DR Pfam; PF00431; CUB; 27.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 3.
DR SMART; SM00042; CUB; 27.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 27.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS01180; CUB; 27.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..3622
FT /note="Cubilin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5027783105"
FT DOMAIN 134..170
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 172..213
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 353..389
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 399..433
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 435..471
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 477..591
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 595..707
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 713..821
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 822..933
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 937..1047
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1053..1167
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1171..1283
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1284..1395
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1397..1512
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1516..1624
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1625..1739
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1743..1855
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1857..1968
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1983..2096
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2097..2218
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2222..2339
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2341..2453
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2457..2567
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2572..2689
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2691..2803
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2807..2922
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2923..3038
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3040..3153
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3160..3276
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3280..3392
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3394..3506
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 3510..3622
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT REGION 26..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 160..169
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 203..212
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 403..413
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 423..432
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 461..470
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1625..1652
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 2341..2368
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 3040..3067
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
SQ SEQUENCE 3622 AA; 390768 MW; F718B3B0632B6B25 CRC64;
MARPAPSPVL WALLLLLLVP APARCEPGQP EKTRSTRSLQ DRQPRITSER GSLVFRTDSD
GDIEFRTGFQ GRIKVNDRDL GTSLLQIQGN AAEITEFKRV GAAFMHNVSS RLSQLQSRVR
RRGHGCRLCA QAAQRRVCSS NPCQNGGTCL NLLDSFFCLC PPSWKGPVCS ADVNECETFA
GSPYSCQNGA TCVNTAGSYS CTCLPDNYGP QCASTYNGCQ LGSLALCGHG FCEDLAPQHV
GEPKYRCVCA PGWAVPPGSS ACTADVDECS LPSPPCSQNP PVQCHNTFGS FYCGPCPAGW
QGNGHVCHDV NECEIANGGC STAPKVQCTN TAGSYLCGPC PPGYQGDGKE CTPEIICSEQ
NGGCHPDALC FPSPGVRPIC VCRPGYTGDG YGANGCVPLS TICESHPCVH GQCTVTSGYQ
CTCNSGWGGP NCTENINECL SSPCLHGGSC TDGIGGYTCE CTNSWTGPRC ETPQQACGGS
LSGMNGTFSY PNNPGAEEYD HNITCSWVLR TEVDKVLRIT FPFFQLEASR HCQYDYLQIH
DGDSSSAYPL GKFCGSNPPA ELFSSHSTLY FLFHSDHSVS AGGFTVRWES RRPECGGMLS
GSYGSISSPG YPNTYPSNRD CIWVVIAKPG LLITFAFGIL SLEHHRNCSF DYLQIQDGPL
PQDPILGKYC SSSLPPPLQT TGPMARVRFH SDASIGDRGF HITYVTSPAD PGCGGNYTDG
AGVITSPDWP NSYISNRQCV YVIRQPPGEL VHLNVTHVEL EGREGCSHSY IEVRDAETLL
RKICGNVILS PVVSISNSIW VRFKSDPSAQ KASFRATYQV ACGGELSGTG TLQSPYYPRA
YPHPTTCEWI IRQPLGQEIL LNFLAFRIAE SPGCGSDYVE IGNGSSVDNL QGRKYCGTDI
PALIKSTSNF LRVTFRTSSS LANLGFKAEF WGADLVCGEI LTAATGTIQS PGHPNPYPHG
VNCTWFISVT PGLRIRLSFS AFHLDFHYNC TTDYLLVYDN GTGTTIGRFC GKSVPPSLTS
SDNMLTLFLV TDSDLAFEGF AASYVTINAS TACIENHEED MGVLTSPLYP NHYPNNWECI
YTITVGTAQQ IALVFTNFSL EPSVGQHCVG DFVEIRDGGY ETSPLLGKYC GTQKPPPIIS
HSNRLWIKFK SDVVISGPGF SAHWDGSLTG CGGNLTTSQG SFTSPNYPMP YYHQSECSWK
LQASRGSPFE LQFVDFHLQE HPNCSSDYLA VYDGPTTRAR LLAKLCGDQI PSPIRSSGDS
LSLKLRTDED QQGAGFLATY RQVCQGVVIA NQSRGTLESI HFPLPYPQNE RCNWSIQAPA
GNAVNYTFST FDLEDSDNCL IDYVELYDGP NRIGRFCGRN APPPGGTTQA RLHVLLHTDG
VPSPNRGFQM QWSVHGCGGE LSGARGSLES PGYPDQYPAS TECIWHITTT PGSSILLTLQ
DFNVEYHPNC NFDVLEVYGG PDFRSPRLAQ LCFPRARENP LRVSSTGNAL TVRFKTDRSV
SGRGFAATWQ EVPGGCGGNF QVPRGEIHSP NYPHPYGRNS DCSWIIQVDG GHHVLLNFTD
FDLDPQDSCV EVYDGPHATS ELLLHRCGQQ LPDSITSSGN TVVVRFQSGQ ATQHRGFWAR
FTEACGSTII TASSGAISSP TFPARHPSHQ NCSWVVRARH PFNHISLSFT AFDLEGSVNC
SRDSVEVLDG ASDDAPVQGR YCGSTLPAPV TSFSNSLIIR FVSYSILASK GFRAVYEASS
SACGGAFHVD EGVINSPGYP DPYPTNTECV WTILSSPGNQ FQLSFVMFQL EQSQDCHKDF
LEIREGNATG HPVGRFCGGT LPRNYSSTLG HILWLRFVSD GAVTGRGFQA AFAHVFGNDN
IMGSRGLIAS PLWPQNYPHN SDYRWTVNGN SSSVVHGTIQ ELDVEMSTGC YYDKLSIHDG
PSIHSRLIGS YCGFTGTTFA STGPSITFHF LSDSSRTGRG FLLEWHLVAA PEGPPPTITP
GACGGVLRTR DSPAFFFSPG WPGDYRNGAD CTWLLHAPDS TVELNVLSLD LESHQTCNYD
QLVIRDGDTN RAPLLATLCG RDLPGPIRST GDFMFVRFTT DSSITGAGFN ASFHQSCGGL
LHVDRGVITS PNYPDSFPPN LNCSWHVKVR EGLTVGVHFE QPFQIPNGDL YCSRGDYLEL
RNGPDASSPP LGPSRGNGRL CGNRPPSSLF TTDNQMLVRF VSDSSGGGQG FKVQYEAKSL
ACGGTIYVHD ASSAGSVSSP GYPSAYPQHA DCTWTISVSA DKVIELQFED PFHVGTSSNC
SSSYLELRDG ADASAPPLAR LCGTTRPARR VSSGSTVRLR FRSDDSSPQA GFRARISIAL
CGGTVAGQSG VAHSPGFPAL SYEDNLECEW HLQGPAGHYL TITFEALGLQ NSTGCTQDFV
ELRESGPSGP VLGRYCGSSV PGAVGTAGNV AFVKFVTDGS VGGPGFQLRF QASTGGCGGD
LVGPTGSLAS PGSRRPHRRI CEWRVTAPEG RRVALTFHDL SLEGRPGCSG EYVIFNGIRR
NSPQLQRLCG QEDRGTRVVS SGNTMKVLYF TDGSGPGRGF GATYTSAEDA VCGGRLSDPL
GGNVTSPGYD GISNYSSNLN CEWILSNPNR HNSSIYISLD DFHLEPHQDC HNDLLEFRVG
DAEGPLIWKL CGHSVPSLPF AVASPQIWMH LVTDERGSDT GFHAHYSFTD CGGVQSGEGG
VIASPNFPAP YGNVNRCSWL LNAPPGHTIT LTFTSFDIES HRTCSWDSVT VINGGSPGSP
VIGRFCGATV PGPIQSGANQ LVVIFNSDHS VQGGGFRATW TSETSGCGGF IHSASGVLHS
PRWPRPFPEN SRCTWTVITH ESQHLELSFH GDFHIPSRDG RCEESHLKVW AGTPGVGADV
PLVTACDSSA PGPTVTPRNQ FTAVFQAREG TGSGFSLTFL SRCGANFTAP TGYVVSPNYP
GQYDNNLRCN YVIEAEPRAV VLLQFITFQL EAPSARGGGC INDGLKVIRG RRVTSVPFAT
LCGHELPQAI SFSGPMLLSF YTDSQTADFG FEASYRVLAC GGTFNASFGT IRSPAYALSD
YPNNMDCTYL ISVRDGKVVE LKFNDFNLEA SDYCSADYVA VRDGLEPGAP LLGKFCGSEL
PARIRSSGDH LRLEFRTNFF QGARGWRASF RETLGPQHGC GGYLTRPGDT FGSPDTDSDG
RYDRNLDCVW TISVPPNGLI NLTFTVFALE DATARGCLYD YVKLYDGASE NASLVGEFCG
SSMPASFLSG GNFLTVKFVS DGSLERPGFN ATYATLDLPC GGTYNATSAV QTTRSPRVLG
SGLSFPACTW VVDAPPRRQV KVAVREFRLR SENCAQNFLQ LRDSYQSLGR RFCGQDASAV
HEFYSSGRTA VVVFRSDVFD DDNGVTFTYQ VADCNREYSQ GFGSLRSPGW PAAYSDNLDC
VTVLRAAPND TIALFFHSFA VEPTTGCQHD FLEVRNGSDE GAPLLGRYCG TELPNPIFPR
NHVLRLRFKS DVIHSRSGYQ ITWTSSPSGC GGPLSGDTGS FASPGYPGSY SNGTHCEWTI
TAPAGSVVTV RFDLVSIDDP GDCVRNYLIL YDGPDADSAS SGPFCGADTD MAPFVAASHR
VFVLFHAEYV VSPSAFRLSW TS
//
