ID F7D8S4_HORSE Unreviewed; 318 AA.
AC F7D8S4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Potassium channel tetramerization domain containing 10 {ECO:0000313|Ensembl:ENSECAP00000017192.2};
GN Name=KCTD10 {ECO:0000313|VGNC:VGNC:19316};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000017192.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000017192.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017192.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000017192.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017192.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the BACURD family.
CC {ECO:0000256|ARBA:ARBA00025759}.
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DR AlphaFoldDB; F7D8S4; -.
DR SMR; F7D8S4; -.
DR STRING; 9796.ENSECAP00000017192; -.
DR PaxDb; 9796-ENSECAP00000017192; -.
DR Ensembl; ENSECAT00000020908.3; ENSECAP00000017192.2; ENSECAG00000019560.3.
DR VGNC; VGNC:19316; KCTD10.
DR GeneTree; ENSGT00950000183143; -.
DR HOGENOM; CLU_060008_0_0_1; -.
DR InParanoid; F7D8S4; -.
DR TreeFam; TF315649; -.
DR Proteomes; UP000002281; Chromosome 8.
DR Bgee; ENSECAG00000019560; Expressed in synovial membrane of synovial joint and 23 other cell types or tissues.
DR ExpressionAtlas; F7D8S4; baseline.
DR GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0035024; P:negative regulation of Rho protein signal transduction; IBA:GO_Central.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR InterPro; IPR045068; BACURD1-3.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR PANTHER; PTHR11145; BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN FAMILY MEMBER; 1.
DR PANTHER; PTHR11145:SF14; BTB_POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN 3; 1.
DR Pfam; PF02214; BTB_2; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 49..135
FT /note="BTB"
FT /evidence="ECO:0000259|SMART:SM00225"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..299
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 318 AA; 36267 MW; B093D55334E94FC2 CRC64;
MHPTPAGQFG SKAADALPHS GPLTKAPSAG RKWGALGRQR KFPPRPRLRR RLVRAGCFLP
LSLRASRLRR PPTFHGWILI DRCGKHFGTI LNYLRDGAVP LPESRREIEE LLAEAKYYLV
QGLVEECQAA LQNKDAYEPF CKVPVITSSK EEQKLIATSN KPAVKLLYNR SNNKYSYTSN
SDDNMLKNIE LFDKLSLRFN GRVLFIKDVI GDEICCWSFY GQGRKIAEVC CTSIVYATEK
KQTKVEFPEA RIYEETLNIL LYEAQDGRGP DNALLEATGG AAGRSHHLDE DEERERERIE
RVRRIHIKRP DDRAHLHQ
//
