ID F7D9P4_XENTR Unreviewed; 2540 AA.
AC F7D9P4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Talin 1 {ECO:0000313|Ensembl:ENSXETP00000032090};
DE SubName: Full=Talin-1 isoform X2 {ECO:0000313|RefSeq:XP_031750912.1};
GN Name=tln1 {ECO:0000313|Ensembl:ENSXETP00000032090,
GN ECO:0000313|RefSeq:XP_031750912.1,
GN ECO:0000313|Xenbase:XB-GENE-6039297};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000032090};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000032090}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000032090};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000032090}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_031750912.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_031750912.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_031750912.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_031750912.1; XM_031895052.1.
DR Ensembl; ENSXETT00000032090; ENSXETP00000032090; ENSXETG00000014649.
DR Xenbase; XB-GENE-6039297; tln1.
DR eggNOG; KOG4261; Eukaryota.
DR HOGENOM; CLU_000364_1_1_1; -.
DR TreeFam; TF314677; -.
DR Proteomes; UP000008143; Chromosome 1.
DR Bgee; ENSXETG00000014649; Expressed in neurula embryo and 18 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0005925; C:focal adhesion; IEA:InterPro.
DR GO; GO:0001726; C:ruffle; IEA:InterPro.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd10569; FERM_C_Talin; 1.
DR CDD; cd17171; FERM_F0_TLN1; 1.
DR CDD; cd17173; FERM_F1_TLN1; 1.
DR CDD; cd12150; talin-RS; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 5.
DR Gene3D; 1.20.1410.10; I/LWEQ domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.20.1420.10; Talin, central domain; 7.
DR InterPro; IPR036723; Alpha-catenin/vinculin-like_sf.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR032425; FERM_f0.
DR InterPro; IPR035964; I/LWEQ_dom_sf.
DR InterPro; IPR002558; ILWEQ_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR037438; Talin1/2-RS.
DR InterPro; IPR015224; Talin_cent.
DR InterPro; IPR036476; Talin_cent_sf.
DR InterPro; IPR049108; Talin_R4.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR015009; Vinculin-bd_dom.
DR PANTHER; PTHR19981; TALIN; 1.
DR PANTHER; PTHR19981:SF7; TALIN-1; 1.
DR Pfam; PF16511; FERM_f0; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF01608; I_LWEQ; 2.
DR Pfam; PF09141; Talin_middle; 1.
DR Pfam; PF21692; Talin_R4; 2.
DR Pfam; PF08913; VBS; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00307; ILWEQ; 1.
DR SMART; SM01244; IRS; 1.
DR SUPFAM; SSF109880; A middle domain of Talin 1; 1.
DR SUPFAM; SSF47220; alpha-catenin/vinculin-like; 5.
DR SUPFAM; SSF109885; I/LWEQ domain; 4.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50945; I_LWEQ; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT DOMAIN 86..403
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 2292..2531
FT /note="I/LWEQ"
FT /evidence="ECO:0000259|PROSITE:PS50945"
FT COILED 1049..1076
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2499..2526
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2540 AA; 271494 MW; B6D7EFCE553427EF CRC64;
MVALSLKISI GNVVKTMQFE PSTMIYDACR IIRERVPEAQ IGQPNDFGLF LSDEDPKKGI
WLEAGKALDY YMLRNGDTLE YRKKQRPLKI RMLDGTVKTV MVDDSKTMSD LLMTICARIG
ITNYDEYSLV REIMEEKKEE ITGTLKRDKT LLRDDKKMEK LKQKLHTDDE LNWLDPGRTL
REQGVDENET LLLRRKFFYS DQNVDSRDPV QLNLLYVQAR DDILNGSHPV SFDKACEFAG
YQCQVQFGPH NEVKHKPGFL ELKDFLPKEY IKQKGERKIF LAHRQCGNMS EIEAKARYVK
LARSLKTYGV SFFLVKEKMK GKNKLVPRLL GITKECVMRV DEKTKEVIQE WNLTNIKRWA
ASPKSFTLDF GDYQDGYYSV QTTEGEQIAQ LIAGYIDIIL KKKKSKDHFG LEGDEESTML
EDSVSPKKST LLQQQFNQVG KVEHGSVALP AIMRSGASGP ENFQVGSMPQ AQQQTVSGQM
HLGHMPPLTS AQQALTGTIN SSMQAINAAQ ATLDDFDTLP PLGDDAASKA WRKNKMDNSK
HEIHSQVDAI TAGTASVVNL TAGNPADTDY TAVGCAVTTI SSNLTEMSRG VKLLAALMED
EGGNGRQLLH AAKNLAGAVS DLLKTAQPAS TEPRQVLMQA AGNVGMASGE LLKQIGECDT
DSQFQDMLVQ LAKAVASAAA ALVLKAKNVA ERTDDGAQQT QVIAAATQCA LSTSQLVACT
KVVAPTISSP VCQEQLLEAG KQVAKSVEGC VEASEAAVQD PELLKAVGVA ASAVTQALND
LLQHIKKHAS GGPPTGRYDQ ATDTILNVTE NIFSSMGDAG EMVRQARILA QATSDLVGAI
KADAERESDL ENSRKLLSAA KLLADATARM VEAAKGAAAH PDSEEQQQKL REAAEGLRMA
TNAAAQNAIK KKLVHKLEQA AKQAAASATQ TIAAAQNAAS SNKNPAAQQQ LVQSCKVVAD
QIPMLVQGVR GSQSQPDSPS AQLSLISASQ NFLQPGAKLV AAGKAAVPTV SDPASAMQLG
QCTKNLASAL AELRTAAQKA HEACGPLEID SALNLVRSLE QDLQEARAAA REGKLQPLPG
ETMEKCAQDL GSSTKAVSSS IAQLLGEIVH GNENYTGRAA RDVAQALRSL AQASRGVAAN
STDPAVQNAM LECAEDVMDK AGNLIEEAKR AVGKPTDPEG QQRLAQVAKA VSQALSRCVN
CLPGQRDVDA AIKSIGEASK ILLASSFPPG TKNFQEAQGQ LNQAAAGLNQ SANELVQASR
GTPQDLAKAS GKYSHDFNEF LQAGVEMAGQ SQNKEDQAQV VSNLKSISLS SSKLLLAAKA
LSADPAAPNL KSQLAAAARA VTDSINQLIT VCTQQAPGQK ECDNALRELE TVRELLQNPT
EPVNDQSYFH CLDSVMENSK VLGESMAGIS QNAKTCNLPE FGESVSAASK ALCGLTEAAA
QAAYLVGVSD PNSHAGQQGL VDPTQFARAN QAIQMACQNL GDPACTQSQV LSAATIVAKH
TSALCNACRV ASTHTSNPVA KRQFVQSAKE VANSTANLVK TIKALDGAFN DDNRVKCRNA
TVPLIQAVEN LTAFASNPEF ASVPAQISPE GLRAMEPIVT AAKLMLESSS GLIQTARSLA
ANPKDPPQWS VLAGHSRTVS DSIKKLITNM RDKAPGQREC DQAIELLNQS VRDLDQASLE
AISQQLAPRE GISQEALHTQ MQTSVQEISN LIEPMAAAAR ADSSQLGHKV SQMAQYFEPL
THAAIGAASK TINHQQQMNL LDQTKTLAES ALQMLYTSKE AGGNPKVAAH TQEALDEAAQ
MMHEAVEDLT VTLNEAASAA GAVGGMVDSI TQAINKLDEE PAGEPEGSFV DYQTTMVKTA
KAIAVTVQEM VTKSTTNPDE LGTLANQLTN EYGQLAQEAK PAAMTAENEE IGSHIKQRVQ
ELGHNCSLLV TKAGALQCSP NDSYTKKELI ESARRVSEKV SHVLAALQAG NRGTQACITA
ASAVSGIIAD LDTTIMFATA GTLNRENAET FADHREGILK TAKALVEDTK VLVQNATSSQ
EKLAQAAQSS VTTITRLAET VKLGAASLGA EDPETQVVLI NAVKDVAKAL GDLISATKAA
AGKSSDDPSV YQLKNSAKVM VTNVTSLLKT VKAVEDEATK GTRALEATIE HIRQELAVFS
SPEPPPQTST PEDFIRMTKG ITMATAKAVA AGNSCRQEDV IATANLSRRA IADMLRSCKE
AVYHPEVNAD VRMRATRFGK ECAIGYLQLL EHVLLILQKP SPELKQQLAT HSKQVAGSVT
ELIQAAEAMK GTEWVDPEDP TVIAENELLG AAAAIEAAAK KLEQLKPRAK PKQADESLNF
EEQILEAAKS IAAATSALVK AASAAQRELV AQGKVGAIPA NADDDGQWSQ GLISAARMVA
AATSNLCEAA NSAVQGHASE EKLISSAKQV AASTAQLLVA CKVKADHDSE AMRRLQVAGN
AVKRASDNLV KAAQKAAAFQ DHDETVVVKE KMVGGIAQII AAQEEMLRKE RELEEARKKL
AMIRQQQYKF LPSELREDSH
//
