ID F7DBD2_ORNAN Unreviewed; 1207 AA.
AC F7DBD2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=SAM and SH3 domain containing 1 {ECO:0000313|Ensembl:ENSOANP00000019488.2};
GN Name=SASH1 {ECO:0000313|Ensembl:ENSOANP00000019488.2};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000019488.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000019488.2, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000019488.2,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000019488.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000019488.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F7DBD2; -.
DR STRING; 9258.ENSOANP00000019488; -.
DR Ensembl; ENSOANT00000019491.3; ENSOANP00000019488.2; ENSOANG00000012316.3.
DR eggNOG; KOG4384; Eukaryota.
DR GeneTree; ENSGT00940000156778; -.
DR TreeFam; TF350709; -.
DR Proteomes; UP000002279; Chromosome 2.
DR Bgee; ENSOANG00000012316; Expressed in brain and 8 other cell types or tissues.
DR CDD; cd09559; SAM_SASH1_repeat1; 1.
DR CDD; cd09492; SAM_SASH1_repeat2; 1.
DR CDD; cd11967; SH3_SASH1; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 2.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR037627; SASH1_SAM_repeat1.
DR InterPro; IPR037630; SASH1_SAM_repeat2.
DR InterPro; IPR035720; SASH1_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR021090; SPIDER.
DR PANTHER; PTHR12301:SF3; SAM AND SH3 DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR12301; SAM-DOMAIN, SH3 AND NUCLEAR LOCALIZATION SIGNALS PROTEIN RELATED; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF07647; SAM_2; 1.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF12485; SLY; 1.
DR SMART; SM00454; SAM; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 515..576
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 594..658
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 1137..1201
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 78..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 179..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 410..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 578..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 674..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 795..1020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..105
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..496
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 497..514
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 801..817
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 858..882
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 986..1010
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1207 AA; 133423 MW; C64E80A19A1AC609 CRC64;
MVVKVSMWKN EHDGSLGNID DLAQQYADYY NTCFTDVCER MEELRKRRVS QDLDVEKPDA
IPTSLQLRSQ IEESLGFSSA VSTPEAERKL PPLHKSSSEE GSFGKGDWKK KNKFFWQNFR
KNQKGIMRQT SKGEDVGYVA SEITMSDEER IQLMMMVKEK MITIEEALAR LKEYESQHRQ
SGSLDPADWP DGSFPTFDGS SNCNSREQSD DETEEAVKFK RLHKLVNSTR RVRKKLIRVE
EMKKPNTEGV EEQPLDSCPI LDDRSALYSG VHKKPFSCDG SPEQPPEEDS DPLTPSPSSS
SLDTWSTSRK LVKTFSKGDS RGLIKPPKKM GTFFSYPEEE KAQKVCRSLT DGEMRKGLGS
LSHGRTCSFG GFDLTNRSLH IGNNNSDPMD KGGDFVYKEV IKSPTASRIS LGKKVKSVKE
TMRKRMSKKY SNSVPEQDCG PHGMPGSPQP AQPDTDSLDK PKLKAGGSVE SLRSSLSGQS
SMSGQTVSTT DSSTSNRESV KSEDGDEEEP PYRGPFCGRA RVHTDFTPSP YDTDSLKLKK
GDIIDIISKP PMGTWMGLLN NKVGTFKFIY VDVLNEEEEK PKRPHRRRQK GRPPQPKSVE
DLLDRINLKE HMPTFLFNGY EDLDTFKLLE EEDLDELNIR DPEHRAVLLT AVELLQEYDS
NSDQSGSQEK LLIDSQGLSG CSPRDSGCYE SSENLENGKT RKTGPLPTKS STEPNFKDFS
RNQLANYPTL PLTKSVEALK GGEKETRLCG IHTPPAPKSS VQPPCATVAK KNRRSLPVSI
CRSCEALDGP QTAEIWPRSH SLDDLQGEPD AEQDGPGKET ESPPQGGPEV PLKMTSTGKP
RTVPGNRAVE EAPPLTQSKR WSEPQKAQTK KVDCSTGTSV HGTPPPLLPK SYESQPSSVK
HALTRMPLPC HLKIQGGTNN LPLPPKGIET EQKGSHELRT QSKNPSQPPP VPAKKSRERL
SNGLHHPSVP HTGSVPCPGA PYLPVKKSSP SSSADCQSGQ AGKPSSEQEP SPPASIRPPW
LSELPEMTSV QEHGVRLGPA LTRKVSCARG VDLEMLIENK LQAEGIDLTE EPYSDKHGRC
GIPEALVQRY AEDLDQPEKD IATNMDQIRV KQLRKQHRMA IPSGGLTEIC RKPVSPGCIT
SISDWLISIG LPMYASTLTE AGFTTLSKVP SLSQTCLQEA GITEERHLSK LIAAARLFKL
PLNPEAM
//