ID F7DBR8_HORSE Unreviewed; 165 AA.
AC F7DBR8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 4.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Coiled-coil-helix-coiled-coil-helix domain containing 2 {ECO:0000313|Ensembl:ENSECAP00000017777.4};
GN Name=CHCHD2 {ECO:0000313|Ensembl:ENSECAP00000017777.4,
GN ECO:0000313|VGNC:VGNC:58792};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000017777.4, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000017777.4, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017777.4,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000017777.4}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017777.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F7DBR8; -.
DR STRING; 9796.ENSECAP00000017777; -.
DR PaxDb; 9796-ENSECAP00000017777; -.
DR Ensembl; ENSECAT00000021575.4; ENSECAP00000017777.4; ENSECAG00000020283.4.
DR CTD; 51142; -.
DR VGNC; VGNC:58792; CHCHD2.
DR GeneTree; ENSGT00440000038159; -.
DR HOGENOM; CLU_093520_2_2_1; -.
DR InParanoid; F7DBR8; -.
DR OMA; CDADARN; -.
DR OrthoDB; 2912282at2759; -.
DR TreeFam; TF318060; -.
DR Proteomes; UP000002281; Chromosome 13.
DR Bgee; ENSECAG00000020283; Expressed in adult mammalian kidney and 23 other cell types or tissues.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0034599; P:cellular response to oxidative stress; IEA:Ensembl.
DR GO; GO:0007005; P:mitochondrion organization; IBA:GO_Central.
DR GO; GO:1905448; P:positive regulation of mitochondrial ATP synthesis coupled electron transport; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:1900037; P:regulation of cellular response to hypoxia; IEA:Ensembl.
DR InterPro; IPR010625; CHCH.
DR PANTHER; PTHR13523; COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77; 1.
DR PANTHER; PTHR13523:SF3; COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 2-RELATED; 1.
DR Pfam; PF06747; CHCH; 1.
DR PROSITE; PS51808; CHCH; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 128..160
FT /note="CHCH"
FT /evidence="ECO:0000259|Pfam:PF06747"
FT REGION 32..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 89..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..56
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 165 AA; 17332 MW; EBF8C391B317462A CRC64;
MVLAQGLMRL ERNEAPPFEG ICFTPPCRSP QMRAAPRPAP AAQPPAPAPP SAVGSPAAAP
RQPGLMAQMA TTAAGVAVGS AVGHTLGHAI TGGFSGGSNA EPSRPDITYQ EPQGTQPVYQ
QQEQFGPCHY EMKQFLECAQ NQSDLKLCEG FSEVLKQCRF ANGLA
//
