ID F7DDW7_HORSE Unreviewed; 981 AA.
AC F7DDW7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 24-JAN-2024, entry version 59.
DE RecName: Full=Peroxisomal ATPase PEX6 {ECO:0000256|ARBA:ARBA00034811};
DE AltName: Full=Peroxin-6 {ECO:0000256|ARBA:ARBA00034920};
GN Name=PEX6 {ECO:0000313|Ensembl:ENSECAP00000017439.2,
GN ECO:0000313|VGNC:VGNC:21331};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000017439.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000017439.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017439.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000017439.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017439.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00034440};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066;
CC Evidence={ECO:0000256|ARBA:ARBA00034440};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the AAA ATPase family.
CC {ECO:0000256|ARBA:ARBA00006914}.
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DR AlphaFoldDB; F7DDW7; -.
DR SMR; F7DDW7; -.
DR STRING; 9796.ENSECAP00000017439; -.
DR PaxDb; 9796-ENSECAP00000017439; -.
DR Ensembl; ENSECAT00000021188.3; ENSECAP00000017439.2; ENSECAG00000019577.3.
DR VGNC; VGNC:21331; PEX6.
DR GeneTree; ENSGT00550000074953; -.
DR HOGENOM; CLU_000688_0_8_1; -.
DR InParanoid; F7DDW7; -.
DR OMA; IPSVFWQ; -.
DR OrthoDB; 7477at2759; -.
DR TreeFam; TF106428; -.
DR Proteomes; UP000002281; Chromosome 20.
DR Bgee; ENSECAG00000019577; Expressed in liver and 23 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005778; C:peroxisomal membrane; IBA:GO_Central.
DR GO; GO:0097733; C:photoreceptor cell cilium; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:Ensembl.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0140318; F:protein transporter activity; IEA:Ensembl.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR GO; GO:0140036; F:ubiquitin-dependent protein binding; IEA:Ensembl.
DR GO; GO:0016558; P:protein import into peroxisome matrix; IBA:GO_Central.
DR GO; GO:0016562; P:protein import into peroxisome matrix, receptor recycling; IEA:Ensembl.
DR GO; GO:0016561; P:protein import into peroxisome matrix, translocation; IEA:Ensembl.
DR GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
DR GO; GO:0043335; P:protein unfolding; IEA:Ensembl.
DR CDD; cd19527; RecA-like_PEX6_r2; 1.
DR CDD; cd19481; RecA-like_protease; 1.
DR Gene3D; 1.10.8.60; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047533; RecA-like_PEX6_r2.
DR PANTHER; PTHR23077; AAA-FAMILY ATPASE; 1.
DR PANTHER; PTHR23077:SF9; PEROXISOME ASSEMBLY FACTOR 2; 1.
DR Pfam; PF00004; AAA; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00674; AAA; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Peroxisome biogenesis {ECO:0000256|ARBA:ARBA00022593};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 463..598
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 737..875
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
SQ SEQUENCE 981 AA; 104256 MW; A83CF627DDC1E3BF CRC64;
MALAVLRVLE PFPTETPPLA VLLPPGGPWP AAGLGLVLAL RPAGESPAGP ALLVAALEGP
GAETEEQGPG PPQLLVSRAL LRLLALGSGA WVRARPVRRP PALAWALLGT SPGPGLGPRV
GPLLVRRGEV LPVPGPRVLE TRPALQGLLG PATRLAVTEL RERAKLGPEP GDSSRPPPPP
VVSSFAVSST VRRLRGVLGG TGDSLGVSRS CLRSLGLFQG EWVWVTRAGE SSNASQPHLA
TVQVLEPRWD LSERLGPGSG QQLGEPLADG LALVPATLAF NLGCDPLEVG ELRIQRYLEG
SSAPEDKGSC SVLPGPPFAK ELHVEIVSSP HYSSNGNYDH VLYRHFQTPR AVQEGDVLCV
PTVGQVEILE GSPEKLPRWR EMFFKVKKTV GDAPDGPTSA YLANTTHTSL YLVGSTLSRV
PRLPSEESTP WSSLSPPGLE ALVTELCVAL KPRLQPGCAL LTGTSSVLLR GPPGSGKTTA
VAAACGRLGL HLLKVPCSSL CADSSGAVEM KLQATFSRAR CCRPVVLLLT AVDLLGRDRD
GLGEDARVVA TLRHLLLDED PLTSCPPLMV VATTSRAQDL PADVQTAFLH ELEVPVLSEG
QRLSILRALT AHLPLGQEVN LAQLARRCAG FVVGDLYALL THSSRAACTR IKNLGLAGGW
SEEDEGELCA AGFPLLAEDF GQALEQLQAA HSQAIGAPKI PSVSWHDVGG LQEVKKEILE
TIQLPLEHPE LLSLGLRRSG LLLYGPPGTG KTLLAKAVAT ECSLTFLSVK GPELINMYVG
QSEENVREVF ARARAAAPCI IFFDELDSLA PSRGRSGDSG GVMDRVVSQL LAELDGLHST
QDVFVIGATN RPDLLDPALL RPGRFDKLVF VGVSEDRASQ LRVLSAITRK FKLEPSVSLV
NVLDRCPPQL TGADLYSLCS DAMTAALKRR VRDLEEGLEP GSSTLLLTME DLLQAAARLQ
PSVSEQELLR YKRIQRKFAA C
//