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Database: UniProt
Entry: F7DDW7_HORSE
LinkDB: F7DDW7_HORSE
Original site: F7DDW7_HORSE 
ID   F7DDW7_HORSE            Unreviewed;       981 AA.
AC   F7DDW7;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 2.
DT   24-JAN-2024, entry version 59.
DE   RecName: Full=Peroxisomal ATPase PEX6 {ECO:0000256|ARBA:ARBA00034811};
DE   AltName: Full=Peroxin-6 {ECO:0000256|ARBA:ARBA00034920};
GN   Name=PEX6 {ECO:0000313|Ensembl:ENSECAP00000017439.2,
GN   ECO:0000313|VGNC:VGNC:21331};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000017439.2, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000017439.2, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017439.2,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA   Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA   Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA   Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA   Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA   Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA   Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA   Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA   Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000017439.2}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017439.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC         Evidence={ECO:0000256|ARBA:ARBA00034440};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066;
CC         Evidence={ECO:0000256|ARBA:ARBA00034440};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}.
CC   -!- SIMILARITY: Belongs to the AAA ATPase family.
CC       {ECO:0000256|ARBA:ARBA00006914}.
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DR   AlphaFoldDB; F7DDW7; -.
DR   SMR; F7DDW7; -.
DR   STRING; 9796.ENSECAP00000017439; -.
DR   PaxDb; 9796-ENSECAP00000017439; -.
DR   Ensembl; ENSECAT00000021188.3; ENSECAP00000017439.2; ENSECAG00000019577.3.
DR   VGNC; VGNC:21331; PEX6.
DR   GeneTree; ENSGT00550000074953; -.
DR   HOGENOM; CLU_000688_0_8_1; -.
DR   InParanoid; F7DDW7; -.
DR   OMA; IPSVFWQ; -.
DR   OrthoDB; 7477at2759; -.
DR   TreeFam; TF106428; -.
DR   Proteomes; UP000002281; Chromosome 20.
DR   Bgee; ENSECAG00000019577; Expressed in liver and 23 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005778; C:peroxisomal membrane; IBA:GO_Central.
DR   GO; GO:0097733; C:photoreceptor cell cilium; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:Ensembl.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0140318; F:protein transporter activity; IEA:Ensembl.
DR   GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR   GO; GO:0140036; F:ubiquitin-dependent protein binding; IEA:Ensembl.
DR   GO; GO:0016558; P:protein import into peroxisome matrix; IBA:GO_Central.
DR   GO; GO:0016562; P:protein import into peroxisome matrix, receptor recycling; IEA:Ensembl.
DR   GO; GO:0016561; P:protein import into peroxisome matrix, translocation; IEA:Ensembl.
DR   GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
DR   GO; GO:0043335; P:protein unfolding; IEA:Ensembl.
DR   CDD; cd19527; RecA-like_PEX6_r2; 1.
DR   CDD; cd19481; RecA-like_protease; 1.
DR   Gene3D; 1.10.8.60; -; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR003960; ATPase_AAA_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR047533; RecA-like_PEX6_r2.
DR   PANTHER; PTHR23077; AAA-FAMILY ATPASE; 1.
DR   PANTHER; PTHR23077:SF9; PEROXISOME ASSEMBLY FACTOR 2; 1.
DR   Pfam; PF00004; AAA; 2.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS00674; AAA; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW   Peroxisome biogenesis {ECO:0000256|ARBA:ARBA00022593};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT   DOMAIN          463..598
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          737..875
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
SQ   SEQUENCE   981 AA;  104256 MW;  A83CF627DDC1E3BF CRC64;
     MALAVLRVLE PFPTETPPLA VLLPPGGPWP AAGLGLVLAL RPAGESPAGP ALLVAALEGP
     GAETEEQGPG PPQLLVSRAL LRLLALGSGA WVRARPVRRP PALAWALLGT SPGPGLGPRV
     GPLLVRRGEV LPVPGPRVLE TRPALQGLLG PATRLAVTEL RERAKLGPEP GDSSRPPPPP
     VVSSFAVSST VRRLRGVLGG TGDSLGVSRS CLRSLGLFQG EWVWVTRAGE SSNASQPHLA
     TVQVLEPRWD LSERLGPGSG QQLGEPLADG LALVPATLAF NLGCDPLEVG ELRIQRYLEG
     SSAPEDKGSC SVLPGPPFAK ELHVEIVSSP HYSSNGNYDH VLYRHFQTPR AVQEGDVLCV
     PTVGQVEILE GSPEKLPRWR EMFFKVKKTV GDAPDGPTSA YLANTTHTSL YLVGSTLSRV
     PRLPSEESTP WSSLSPPGLE ALVTELCVAL KPRLQPGCAL LTGTSSVLLR GPPGSGKTTA
     VAAACGRLGL HLLKVPCSSL CADSSGAVEM KLQATFSRAR CCRPVVLLLT AVDLLGRDRD
     GLGEDARVVA TLRHLLLDED PLTSCPPLMV VATTSRAQDL PADVQTAFLH ELEVPVLSEG
     QRLSILRALT AHLPLGQEVN LAQLARRCAG FVVGDLYALL THSSRAACTR IKNLGLAGGW
     SEEDEGELCA AGFPLLAEDF GQALEQLQAA HSQAIGAPKI PSVSWHDVGG LQEVKKEILE
     TIQLPLEHPE LLSLGLRRSG LLLYGPPGTG KTLLAKAVAT ECSLTFLSVK GPELINMYVG
     QSEENVREVF ARARAAAPCI IFFDELDSLA PSRGRSGDSG GVMDRVVSQL LAELDGLHST
     QDVFVIGATN RPDLLDPALL RPGRFDKLVF VGVSEDRASQ LRVLSAITRK FKLEPSVSLV
     NVLDRCPPQL TGADLYSLCS DAMTAALKRR VRDLEEGLEP GSSTLLLTME DLLQAAARLQ
     PSVSEQELLR YKRIQRKFAA C
//
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