ID F7DGU7_ORNAN Unreviewed; 3944 AA.
AC F7DGU7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=VWFC domain-containing protein {ECO:0000259|PROSITE:PS50184};
GN Name=FRAS1 {ECO:0000313|Ensembl:ENSOANP00000005651.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000005651.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000005651.3, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000005651.3,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000005651.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000005651.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FRAS1 family.
CC {ECO:0000256|ARBA:ARBA00005529}.
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DR STRING; 9258.ENSOANP00000005651; -.
DR Ensembl; ENSOANT00000005653.3; ENSOANP00000005651.3; ENSOANG00000003565.3.
DR eggNOG; KOG1216; Eukaryota.
DR eggNOG; KOG1306; Eukaryota.
DR eggNOG; KOG3525; Eukaryota.
DR eggNOG; KOG3597; Eukaryota.
DR GeneTree; ENSGT00940000163761; -.
DR HOGENOM; CLU_000244_0_0_1; -.
DR TreeFam; TF316876; -.
DR Proteomes; UP000002279; Chromosome 10.
DR Bgee; ENSOANG00000003565; Expressed in adult mammalian kidney and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR CDD; cd00064; FU; 13.
DR Gene3D; 2.60.40.2030; -; 5.
DR Gene3D; 6.20.200.20; -; 4.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR039005; CSPG_rpt.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR45739:SF1; EXTRACELLULAR MATRIX ORGANIZING PROTEIN FRAS1; 1.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF16184; Cadherin_3; 10.
DR Pfam; PF03160; Calx-beta; 5.
DR Pfam; PF00093; VWC; 5.
DR SMART; SM00237; Calx_beta; 5.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00261; FU; 13.
DR SMART; SM00214; VWC; 6.
DR SUPFAM; SSF141072; CalX-like; 5.
DR SUPFAM; SSF57603; FnI-like domain; 6.
DR SUPFAM; SSF57184; Growth factor receptor domain; 5.
DR PROSITE; PS51854; CSPG; 12.
DR PROSITE; PS01208; VWFC_1; 3.
DR PROSITE; PS50184; VWFC_2; 6.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 3838..3859
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 7..60
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 65..125
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 129..189
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 191..252
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 256..316
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 349..395
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT REPEAT 1031..1127
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1147..1239
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1264..1375
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1401..1497
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1533..1627
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1648..1748
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1770..1872
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1893..1993
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2014..2113
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2138..2230
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2250..2343
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 2378..2475
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REGION 1321..1344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3864..3900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3944 AA; 428053 MW; 9367369121234EF7 CRC64;
MPPFVFFQNA AVWKSDSCQE CRCHGELVLC KPVPCKDPGC DTEKGEVLRI GPGQCCPECV
SPLQGSCRHE GEVHAHGTEW SSRPCGVCSC MNGTVRCHRN PCPAVSCGPG TVARVPEGGC
CPRCLGTGEP CQLDGRLLRD GEERQLSLCA RCVCRNGTSQ CFSAECPSLL CPQGEKAVRL
AGHCCPRCLP RTCVTAAGTE RQHGERWAEG PCVTCQCVGG ETRCHRAACV PHTCDQGRSP
GQRPGKCCEH CQPSQGACWS AGALRSPGEL WAGPACDFCS CERGRVTCRP VECARVDCAQ
GEERIHLVGK CCPECLPRQR HCAYEEVTGG GSAQLTVSGL SDVGHIPEGE TWQQGLCRMC
RCQDAQVICY RPSCPPCPVG TWAVARTGQC CPECTTVPCH SSCLACSRSP EHCDRCRDAT
KLLQDGRCVD TCQTGFYQEA GACLACRKDC LTCTSGFQCS SCPDSWLLKE GRCVAACGEG
FYQRHRSCAV CHRSCAACRG PTGKDCLACR DRARVLKAGA CESHCGQGFY RQGGVCIACH
ISCTRCVGPS ANHCTLCSSS LVLYQGHCLS GCGENFYPDH GVCQACHPSC LSCVGPEPSD
CTRCRNPEEG LQAERHLRAT SVGTCLSRCK PRFYLKDTGF CEVCDGSCRA CVGSSPHNCT
SCPSTHVLLD GRCLSHCPPG FFRQDAACSA CHPTCRECRA GSDSDCIACH PHAALSGGTC
QNDCRDGQYL DPVGSCADCH PLCRHCTADP RHQGSVCLRC QNAHHLLLGD GCVPACPTGY
YAERGACNEC HPSCKSCLGE GPTSCSACDE ALVLSHTGRC VTACYPGYYL DQGRACQVCG
SLCRSCASPT SCTSCRDPAQ VLLQGKCLDS CGQQYFLDVA TRTCKDCHGS CGACRGPLGT
DCLQCVTGYA LQEGACVPRC SPAFYRDSDT CRSCDEGCVQ CRGPRQCSLC EAPFLLQEGL
CVSQCQQGRF PDLTQKACTA CPPQCLQCDR EERCLVCSGS TFLKEGRCVT SCGPGFYPHP
QTGTCQGNAH PPVLRANGSL VLGVGSTRPL DPSLLDAHDP DGRVADLLFQ VRRPPTNGRL
LLRRAGGERL LLQDSDPFTW DDLREHSVLF VHSPEMPRQG HFSLRVSDGR FSSEPERIDT
LAFSTQGPYV LKNEALRLAP GEIGAISPQL LDIRDDDDPP RDVVVEVVDP PLHGRLFLSP
GPAGAPVRQL RLDELAAGLL HYAHDGSDGA ADVFLLQAGD GYSFRSILLR VQIAPEDGGG
ESSGARLLAN FLAWVPGGGL LPITRQILRA EAPGARPSEI VYVVARDQPE LGEVVLLPTL
PADGPADGEQ PSSGEGAPIP TATFTQQDID DGSVWYRLSG TPAQAQQDSF RFEVSSPAGL
PQSHTESHVF HIGILPQTPG APQLSPGSSL HLEVQDDRVT VIQPRALSFE DSDSPSGDIV
YHVTKPLPPN QGSVEYRDRP YSPARSFTQA DVDEGKVVYR PPPAAPHLQE LMAFSFAGLP
ESLTLHFTVS DGEHTTPEMA LTLHLLPTNG QPPGLQITAP VLEVDQGDRA PLGIQLAGSE
AELAPGDLVF ELVKPPLHGG LLKYTAGFQG PLEAGDIFTY EDVVRQAVLY GHDGSSAPED
SLEISVTGGL TRATTVVRVQ VSVPGSSSPR LAAGSTLTIT VASRSSVVLT RSHLAYEAGS
SPDSEVRIQC AAVPLLGTLT RTAGLEVEEL SQASSFTMED VNSHSIRYWT GFETDGHPAT
DSFRFSVAAT HGQLDDQVLT ITIVPGQKQP PVLTFADLVT VDEGGRAPLT FHHFFATDSD
PMPDGAAVTI SSPPKFGCIE NTRTGGRFGP EGSGGRLASF LVRDIEEHHV YYFQSIHELT
EPTHDAFSFY VSNGSLQAEI HTVNITIQRK SDRSPTLTLQ PVQVWASSGA LIQNTSIGLR
DLDTPDDQLI FVLIREPEHG RLYRKEQQAG ALADGRVLSR GTSFSYRDVV DGLLGYTPDL
PAASADEFHF SVTDGLHTET GRMEIHLHLP ESQLLHLAQN QALQLPAGST ARITEQHLHV
TDKDSGGLRV RYVVKKDPSV GHLQMTQRGE PVQVSAHGPV RSFTQADVSN GLVEYSHPGG
ESGGEFSFQF DVVDGEGSEG SRLVDQYFTI RVLEDNLPPS ITANEGLVLD ENSVKTITTL
QLSATDRDSG PEKLRYRITQ RPQLGHLEHS ASPGTRIDSF TQADLASRGV QYHHTSTAEI
HADAFSFTVS DGTNEVGQTF HISINPVDDS LPVVTSPGMR VQEGLRKTIS EFELKAVDAD
TEAESVTFTI VQPPRHGTID RISDGQLSRR TTTFTMEDIY QSRVSYRHDG SDSLRDRFTF
TVSDGTNPFF RVEEGGKEIV TAAPQKFKVD ILPIDDGTPR IITNLGLQWL EYMDGKASNL
ITKKELLTAD PDTEDRQLVY EITSGPRHGS LHHGLQPGAV VTTFTQEDVN LGLLRYVLRD
EKIQETMDSF QFLVKDSLPN VVSDNTFHIQ WSLISFKHTS YNVSEKAGSV SVTVERTGNL
NQYAIVLCHS KQGTATSTSS PGPKPGQSDF VEYAGQVQFD EREDTKSCTI VINDDEVFEN
VESFTVELSM PAYALLGAVT HAEVNINDTE DEPTLQFDRK TYRVNESAGV LPVPIERGGD
SSSFVSAICY TVPRSAKGSS LYAPESGSDF KSRGLSEASR VVLGPGVTLA SCEVVLIDDS
EYEEEEEFEV VLAGPSANAR VGRASSATVL ISGPNDASTV ALGNTAFTVS EDAGVIKIPV
VRHGTDLSTF ASVWCATRPS DPPSATPGVD YIPSSRKVEF GAGDTEQSCP LTILDDAQKP
AIEGLETFVV FLSSAQGAEL SKPSQAVIAI NDTFQDVPSM QFGKDSYPVR EKDGAVHIPV
IRSGDLNYES SVRCLTLSQT ARVTEDFEGR TDADSARITF LKGEKVKNCT VYINDDSVFE
PEERFTVSLG HPLGNHWSGA RVGKNSVATV TISNEEDAPT IEFEEATYQV REPRGPEAVA
VLSVGVIRRG DLNRTSKIRC STRDGSAQSG LDYYPKSRIL KFGPGEARSV FKVEIMSNED
REWHESFSLV LGPDEPVEAV LGDVATATVT ILDQEAAGSL ILPAPPIVVS LADYDHVDEV
TKEGAKKSPS PGYPLVCVTP CDPHYPQFAL TKERCGEAGI NQSSVRFGWE VAAPTDSSGA
RSPFEAVTDN TPFTGVSHVV LDSIYFSRRF HVRCVAKAVD RAGHVGTPLR SPAVTIGTDG
TLCHTPVVAG TARGFQAQSF IATLKYLDVK HKEHPNRIHI SVQIPHQDGM LPLISTMPLH
NLHFLLSESI YRHQHVCSNL NTARDPKGTS EAGFLGEGMT GSGLALGPGY DRPYQFDPSV
REPKTIQLYK HLNLKTCTWT FDAYYDMTEL IDVCGGSVTA DFQVRDSAQS FLTVHVPLHV
SYIYVTAPRG WASLEHHTEM EFSFFYDTVL WRTGIQTDSV LSARLQIVRI YIREDGRLVI
EFKTHAKFRG HFVMEHHTLP DVKSFLMAPD HLGGMEFALQ LLWSAQTFDS PSQLWRATSS
YNRKDYSGEY TIFLIPCTVQ PTQPWIDPGD KPLACTAHAP ERFLIPIAFQ QTSRPVPVVY
SLNTEFQLCN NEKVFLMDPS TPDMSLAEMD YKGAFSKGQT LYGRVLWNPE QNLNSAYRLQ
LEKVYLCTGK DGHVPFFDPM GTVYNEGPQY GCIQPNKHLK HRFLLLDRSQ PEVTDKYFHD
VPFDAHFASD LADFHLVSSM PGVDGFTLKV DALYKVEAGH QWYLQVIYII GPDSVSGPRT
QRSFTAPLRR SRRDLLDDSL VYDNEGDQVK NGTNMKALSL DGPEAGVASA TARTGASVGS
ALAAALLLLL LLLGGCCLAK RCRRPRRKGP EGPGPEDYPL NSKMDVPKRN PDPGEKNAGR
QFCTVRNVNL LRENEAVYKV RGVKVKQVNL EVKVHNNLHD GTEV
//
