ID F7DI60_XENTR Unreviewed; 356 AA.
AC F7DI60;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Leucine-rich repeat and transmembrane domain-containing protein 2 {ECO:0000313|RefSeq:XP_002938140.1};
DE SubName: Full=Leucine-rich repeats and transmembrane domains 2 {ECO:0000313|Ensembl:ENSXETP00000111786};
GN Name=lrtm2 {ECO:0000313|Ensembl:ENSXETP00000111786,
GN ECO:0000313|RefSeq:XP_002938140.1,
GN ECO:0000313|Xenbase:XB-GENE-956030};
GN ORFNames=XENTR_v90028666mg {ECO:0000313|EMBL:OCA19595.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000111786};
RN [1] {ECO:0000313|EMBL:OCA19595.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Nigerian {ECO:0000313|EMBL:OCA19595.1};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Ottilar R., Schmutz J., Salamov A., Cheng J.F., Lucas S., Pitluck S.,
RA Gundlach H., Guo Y., Haberer G., Nasrallah J., Mayer K.F.X.,
RA van de Peer Y., Weigel D., Grigoriev I.V.;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:OCA19595.1, ECO:0000313|Ensembl:ENSXETP00000111786}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|EMBL:OCA19595.1,
RC ECO:0000313|Ensembl:ENSXETP00000111786};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [3] {ECO:0000313|EMBL:OCA19595.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Nigerian {ECO:0000313|EMBL:OCA19595.1};
RA Sessions A., Jenkins J., Mitros T., Lyons J.T., Dichmann D.S., Robert J.,
RA Harland R.M., Rokhsar D.S.;
RT "WGS assembly of Xenopus tropicalis.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Ensembl:ENSXETP00000111786}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2021) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:XP_002938140.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_002938140.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_002938140.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SLITRK family.
CC {ECO:0000256|ARBA:ARBA00010439}.
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DR EMBL; KV460375; OCA19595.1; -; Genomic_DNA.
DR RefSeq; XP_002938140.1; XM_002938094.5.
DR Ensembl; ENSXETT00000107353; ENSXETP00000117093; ENSXETG00000044968.
DR Ensembl; ENSXETT00000108247; ENSXETP00000111786; ENSXETG00000044968.
DR Ensembl; ENSXETT00000120264; ENSXETP00000104999; ENSXETG00000044968.
DR Ensembl; ENSXETT00000123799; ENSXETP00000113775; ENSXETG00000044968.
DR GeneID; 100486802; -.
DR KEGG; xtr:100486802; -.
DR AGR; Xenbase:XB-GENE-956030; -.
DR CTD; 654429; -.
DR Xenbase; XB-GENE-956030; lrtm2.
DR eggNOG; KOG0619; Eukaryota.
DR HOGENOM; CLU_038584_0_0_1; -.
DR OMA; QISWIAC; -.
DR OrthoDB; 4193933at2759; -.
DR Proteomes; UP000008143; Chromosome 3.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007409; P:axonogenesis; IEA:InterPro.
DR GO; GO:1905606; P:regulation of presynapse assembly; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR InterPro; IPR043326; Slitrk.
DR PANTHER; PTHR45773:SF7; SLIT AND NTRK-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR45773; SLIT AND NTRK-LIKE PROTEIN 4-RELATED; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF01462; LRRNT; 1.
DR SMART; SM00369; LRR_TYP; 5.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius, ECO:0000313|RefSeq:XP_002938140.1};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..356
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041197391"
FT TRANSMEM 293..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 32..66
FT /note="LRRNT"
FT /evidence="ECO:0000259|SMART:SM00013"
FT DOMAIN 192..245
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT REGION 248..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..277
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 356 AA; 39767 MW; 1304BEE70B2951FB CRC64;
MRVARRYYPG RWAQGSFIAC CLSLCAASSL LSCPSLCKCN TSSLEVDCSG RGLTSVPPDI
PQDTRTLLLL NNRLSSLSEK AFSNLSSLHR LDISNNFLDQ LPSQLLSDLG NLTELRLRNN
SIRSLDRDIL QGLSLLRRLD LSLNGLSQLP SGLFDGLSML HWLSLHSNRL QSLDRETFEP
LDKLEIIQLG DNPWECDCNL RDFKHWMEWF TYRGGKMDEL QCTLPKDLRG RDIRMVPVEM
FSYCSQLEDE NSSGPADKPG PPCTKASPAP LEPDPGPDCP QRQRYRPASV RRAIGTVIIA
GVVCGVVCIM MVVAAAYGCI YASLMAKYHR ELKKRQPLMG DAEGEQEEQR QISSVA
//
