ID F7DM96_HORSE Unreviewed; 585 AA.
AC F7DM96;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Acyl-CoA synthetase family member 3 {ECO:0000313|Ensembl:ENSECAP00000012884.1};
GN Name=ACSF3 {ECO:0000313|Ensembl:ENSECAP00000012884.1,
GN ECO:0000313|VGNC:VGNC:15003};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000012884.1, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000012884.1, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000012884.1,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000012884.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000012884.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR RefSeq; XP_001488201.1; XM_001488151.3.
DR AlphaFoldDB; F7DM96; -.
DR SMR; F7DM96; -.
DR STRING; 9796.ENSECAP00000012884; -.
DR PaxDb; 9796-ENSECAP00000012884; -.
DR Ensembl; ENSECAT00000015979.3; ENSECAP00000012884.1; ENSECAG00000015121.3.
DR GeneID; 100051639; -.
DR KEGG; ecb:100051639; -.
DR CTD; 197322; -.
DR VGNC; VGNC:15003; ACSF3.
DR GeneTree; ENSGT00940000157000; -.
DR HOGENOM; CLU_000022_59_11_1; -.
DR InParanoid; F7DM96; -.
DR OMA; YKIPQEM; -.
DR OrthoDB; 5473537at2759; -.
DR TreeFam; TF312995; -.
DR Proteomes; UP000002281; Chromosome 3.
DR Bgee; ENSECAG00000015121; Expressed in adult mammalian kidney and 23 other cell types or tissues.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0090409; F:malonyl-CoA synthetase activity; IEA:Ensembl.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0031957; F:very long-chain fatty acid-CoA ligase activity; IBA:GO_Central.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IBA:GO_Central.
DR GO; GO:0090410; P:malonate catabolic process; IEA:Ensembl.
DR CDD; cd05941; MCS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43201; ACYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR43201:SF8; FATTY ACID COA SYNTHETASE FAMILY; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 1: Evidence at protein level;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F7DM96};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 49..436
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 487..562
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 585 AA; 65678 MW; 2EA418091B8FC42E CRC64;
MPPHVVMSFR RLVWALASHR PAPLRHEGIH LLHAAPAACS DRSAPVFTRA LAFGDRVALV
DQHGHHTYKD LYHRSLCLSR EICRLRECAG GDLQEERISF MCSNDVSYVV AQWASWMSGG
IAVPLYRKHP QAELEYFIQD SRSSVVLAGQ EYVELLSPVV RKLGVPLLPL TPTVYDGVAE
EAGDGQLPER DWRDRGAMII YTSGTTGRPK GVLSTHYNIR AVVTGLVHKW GWTKDDVILH
VLPLHHVHGV VNKLLCPLWV GATCVMLPNF NAQLVWEKFL SSETPRINVF MAVPTIYTKL
MDYYDKHFTQ PHVQDFVRAV CEEKIRLMVS GSAALPLPVL EKWKNITGHT LLERYGMTEI
GMALSNPLTA ARLPGSVGTP LPGVEVRIVS ENPQKEGYPY ILHAEGNEKE TKVTPGFKEK
EGELLVRGPS VFREYWDKPE ETKNAFTSDG WFKTGDTAVF KDGRYWIRGR TSVDIIKSGG
YKISALEVER LLLAHPSITD VAVIGVPDMT WGQRVTAVVT LQEGHSLSHR ELKEWARDVM
APYVVPSELL LVEEIPRNQM GKVNKRDLVR HFYPCNQGAP KAGRQ
//
