ID F7DMF3_ORNAN Unreviewed; 909 AA.
AC F7DMF3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Epithelial cell transforming 2 {ECO:0000313|Ensembl:ENSOANP00000021565.2};
GN Name=ECT2 {ECO:0000313|Ensembl:ENSOANP00000021565.2};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000021565.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000021565.2, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000021565.2,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000021565.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000021565.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F7DMF3; -.
DR STRING; 9258.ENSOANP00000021565; -.
DR Ensembl; ENSOANT00000021568.3; ENSOANP00000021565.2; ENSOANG00000013671.3.
DR eggNOG; KOG3524; Eukaryota.
DR GeneTree; ENSGT00940000156299; -.
DR HOGENOM; CLU_008187_0_0_1; -.
DR TreeFam; TF101161; -.
DR Proteomes; UP000002279; Chromosome 1.
DR Bgee; ENSOANG00000013671; Expressed in fibroblast and 4 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:2000431; P:regulation of cytokinesis, actomyosin contractile ring assembly; IEA:InterPro.
DR CDD; cd17733; BRCT_Ect2_rpt1; 1.
DR CDD; cd17732; BRCT_Ect2_rpt2; 1.
DR CDD; cd01229; PH_Ect2; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 3.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR026817; Ect2.
DR InterPro; IPR049396; ECT2_BRCT0.
DR InterPro; IPR049395; ECT2_PH.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR16777; PROTEIN ECT2; 1.
DR PANTHER; PTHR16777:SF2; PROTEIN ECT2; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF21243; ECT2_BRCT0; 1.
DR Pfam; PF21242; ECT2_PH; 1.
DR Pfam; PF12738; PTCB-BRCT; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00292; BRCT; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF52113; BRCT domain; 2.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50172; BRCT; 2.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT DOMAIN 173..246
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 261..349
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 447..636
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 384..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 909 AA; 102772 MW; C9AEC338D2A6D9DC CRC64;
MVFLIPAPPL ACCVTLADRE VCTRSDMADN SDLISTAGRS FLADTSIFDS RITETTKESS
FIEPALGVEE EMPQIETRVI LVQEAGKQEE LIKALKEIKM PFIKAETVKE LEDADSPEFE
NIFVVKDFQD SVFNDLYKAD CRVLGPPIIL NCAQKGEALP YSCRPLFCGS MLNLVLCFTG
FRKKEELVRL VTLVHHMGGV IRKDFNSKVT HLVASCTQGD KFRVAVSLGT PIMKPEWIYK
AWERRNEQDF CAAHDDFRNE FKVSPFQDCM LSFLGFSDEE KANMEEMTEM QGGNFLPVGD
ERCTHLVVEE NTVKELPFEP PKKLYVVKQE WFWGSIQMDA RAGETMYLYE KADTPELKKS
VSLLSLSTPN SNRKRRRLKE TLAQLARETD MSPFPPRKRP SAEHSLSIGS LLDISNTTES
GSNYGETPKS CAKPSKNSTP VPPKQSARWQ VARELYQTES NYVGILTTIL QLFQVPLEEE
GQRGGPILAP EEIKTIFGSI PDIFEVHTKI KDDLEDLIIH WDESKSIGDI FLKYSRDLVK
TYPPFVNFFE MSKEMIIKCE KQKPRFHAFL KINQAKPECG RQSLAELLIR PVQRLPSVAL
LLNDLKKHTA DENPDKITLE KAIGSLKEVM THINEDKRKT EAQKQIFDVV YEVDGCPANL
LSSHRSLIQR VETISLGEHP CDRGEQVTLF LFNDCLEIAR KRHKVIGAFK SPHGQTRPPA
SLKHIHLMPL SQIKKVLDIR ETEDCHNAFG LLVRPPTEQT NILLSFQMTS EEPPKENWLK
MLCRHVANTI CKADAENLMY TADPESFEVT TKDMDSTLSR ASRAIKKTSK KVTRAFSFSK
TPKRALRRAL LAHSTAEGRS PRSSNDTYIG SRLTSTSSLA GIPSPSLVSL PAFFEKRSHT
LSRSTTHLI
//
