ID F7DNZ4_MACMU Unreviewed; 1309 AA.
AC F7DNZ4; A0A663D722; G7N6N1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=DENN domain containing 5B {ECO:0000313|Ensembl:ENSMMUP00000004302.3};
GN Name=DENND5B {ECO:0000313|Ensembl:ENSMMUP00000004302.3,
GN ECO:0000313|VGNC:VGNC:71772};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000004302.3, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000004302.3}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000004302.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RAB6IP1 family.
CC {ECO:0000256|ARBA:ARBA00006664}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR RefSeq; XP_015006879.1; XM_015151393.1.
DR SMR; F7DNZ4; -.
DR Ensembl; ENSMMUT00000004564.4; ENSMMUP00000004302.3; ENSMMUG00000003221.4.
DR GeneID; 694421; -.
DR CTD; 160518; -.
DR VEuPathDB; HostDB:ENSMMUG00000003221; -.
DR VGNC; VGNC:71772; DENND5B.
DR eggNOG; KOG2080; Eukaryota.
DR GeneTree; ENSGT00940000153678; -.
DR HOGENOM; CLU_004201_2_0_1; -.
DR OrthoDB; 5398783at2759; -.
DR TreeFam; TF313237; -.
DR Proteomes; UP000006718; Chromosome 11.
DR Bgee; ENSMMUG00000003221; Expressed in dorsolateral prefrontal cortex and 21 other cell types or tissues.
DR ExpressionAtlas; F7DNZ4; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR CDD; cd01757; PLAT_RAB6IP1; 1.
DR CDD; cd17691; RUN1_DENND5B; 1.
DR CDD; cd17693; RUN2_DENND5B; 1.
DR Gene3D; 1.20.58.900; -; 2.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR047278; DEN5A/B.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR047277; PLAT_RAB6IP1.
DR InterPro; IPR047293; RUN1_DENND5B.
DR InterPro; IPR047292; RUN2_DENND5B.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR46070:SF3; DENN DOMAIN-CONTAINING PROTEIN 5B; 1.
DR PANTHER; PTHR46070; PINSTRIPE, ISOFORM A; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF02759; RUN; 2.
DR Pfam; PF03456; uDENN; 1.
DR PRINTS; PR02045; F138DOMAIN.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00593; RUN; 2.
DR SMART; SM00800; uDENN; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR SUPFAM; SSF140741; RUN domain-like; 2.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS50826; RUN; 2.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
SQ SEQUENCE 1309 AA; 149389 MW; 25C65C4D1976B1AA CRC64;
MGTHHHAQLI FVFLVEMRFH HVDQAGLKLL TSSNPPASAS QSTEITVVSQ HAQPGFLYQW
LEADRHGKSQ DAANTTSGEN FDQSPLRRTF KSKVLAHYPQ NIEWNPFDQD AVNMLCMPKG
LSFRTQTDNK DPQFHSFIIT REDGSRTYGF VLTFYEEVTS KQICTAMQTL YQMHNAEHYS
SVYASSSCSM DSLASSLDEG DTTSLLKLQR YNSYDISRDT LYVSKSICLI TPLPFMQACK
KFLIQLYKAV TSQQPPPLPL ESYIHNILYE VPLPPPGRSL KFYGVYEPVI CQRPGPSELP
LSDYPLREAF ELLGLENLVQ VFTCVLLEMQ ILLYSQDYQR LMTVAEGITT LLFPFQWQHV
YVPILPASLL HFLDAPVPYL MGLQSKEGTD RSKLELPQEA NLCFVDIDNH FIELPEEFPQ
FPNKVDFIQE LSEVLVQFGI PPEGSLHCSE STSKLKNMVL KDLVNDKKNG NVSTNNISMY
ELLKGNETIA RLQALAKRTG VAVEKMDLSA SLGEKDKDLK LQCEEAELRD YQLNVQLREV
FANRFTQMFA DYEAFVIQTA QDMESWLTNR EQMQNFDKAS FLSDQPEPYL PFLSRFIETQ
MFATFIDNKI MSQWEEKDPL LRVFDSRIDK IRLYNVRAPT LRTSIYQKCS TLKEAAQSIE
QRLMKMDHTA IHPHLLDMKI GQGKYEQGFF PKLQSDVLAT GPTNNNRWVS RSATAQRRKE
RLRQHSDHVG LDNDLREKYM QEARSLGKNL RQPKLSDLSP AVIAQTNCKF VEGLLKECRM
KTKRMLVEKM GHEAVELGHG EANITGLEEN TLIASLCDLL ERIWSHGLQV KQGKSALWSH
LIQFQDREEK QEHLAESPVA LGPERRKSES GVMLPTLRVS LIQDMRHIQN MSEIKTDVGR
ARAWIRLSLE KKLLSQHLKQ LLSNQPLTKK LYKRYAFLRC EEEREQFLYH LLSLNAVDYF
CFTSVFTTIM IPYRSVIIPI KKLSNAIITS NPWICVSGEL GDTGVMQIPK NLLEMTFECQ
NLGKLTTVQI GHDNSGLLAK WLVDCVMVRN EITGHTYRFP CGRWLGKGID DGSLERILIG
ELMTSASDDD LVKQCRTPPQ QKSPTTARRL SITSLTGKNN KPNAGQIQEG IGEAVNNIVK
HFHKPEKERG SLTVLLCGEN GLVAALEQVF HHGFKSARIF HKNVFIWDFI EKVVAYFETT
DQILDNEDDV LIQKSSCKTF CHYVNAINTA PRNIGKDGKF QILVCLGTRD RLLPQWIPLL
AECPAITRMY EESALLRDRM TVNSLIRILQ TIQDFTIVLE GSLIKGVDV
//
