ID F7DP69_XENTR Unreviewed; 2894 AA.
AC F7DP69;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 24-JAN-2024, entry version 66.
DE SubName: Full=Putative ortholog of neurobeachin protein (Lysosomal-trafficking regulator 2), 3 of 3 {ECO:0000313|Ensembl:ENSXETP00000037315};
GN Name=nbeal3 {ECO:0000313|Ensembl:ENSXETP00000037315};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000037315};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000037315}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000037315};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000037315}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
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DR Ensembl; ENSXETT00000037315; ENSXETP00000037315; ENSXETG00000026016.
DR Xenbase; XB-GENE-1001170; nbeal3.
DR eggNOG; KOG1787; Eukaryota.
DR HOGENOM; CLU_000218_2_2_1; -.
DR TreeFam; TF354330; -.
DR Bgee; ENSXETG00000026016; Expressed in brain and 12 other cell types or tissues.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046851; NBCH_WD40.
DR InterPro; IPR010508; NBEA-like_DUF1088.
DR InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR InterPro; IPR046852; Neurobeachin_a-sol.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF62; NEUROBEACHIN; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF06469; DUF1088; 1.
DR Pfam; PF15787; DUF4704; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF20426; NBCH_WD40; 1.
DR Pfam; PF20425; Neurobeachin; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
PE 4: Predicted;
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT DOMAIN 2095..2203
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2222..2511
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REGION 1466..1503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1565..1627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1469..1496
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1565..1588
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2894 AA; 323001 MW; 0098CF7DABD4499B CRC64;
SGPVVGWQVG DGGGDAPGVS SAGGSGSMVL PGGVINPSVP IRNMRMKFAV LIGLIQVGEV
SNRDIVETVL NLLVGGEFDL EMNFIIQDAE SITCMSELLE HCDVTCQAEI WSMFTAILRK
SVRNLQTSTE VGLIEQVLLK MPSVDDMIAD LLVDMLGVLA SYSITVKELK LLFSMLRGEN
GIWPRHAVKL LSVLNQMPQR HGPDTFFNFP GRSAAAIALP PIAKWPYQNG FTLNTWFRMD
PLNNINVDKD KPYLYCFRTS KGVGYSAHFV GNCLIVTSLK SKGKGFQHCV KYDFQPRKWY
MISIVHIYNR WRNSEIRCYV NGQLVSYGDM AWHVNTNDSY DKCFLGSSET ADANRVFCGQ
LGAVYVFIEA LNPAQIFAIH QLGPGYKSTF KFKSESDIHL AEHHKQVLYD GKLASSIAFT
YNAKATDAQL CLESSPKENA SIFVHSPHAL MLQDVKAIVT HSIHSAIHSI GGIQVLFPLF
AQLDNRQLND SQVETTVCAT LLAFLVELLK SSVAMQEQML GGKGFLVIGY LLEKSSRIHI
TRAVLEQFLS FAKYLDGLSH GAPLLKQLCD HILFNPAIWI HTPAKVQLSL YTYLSAEFIG
TATIYTTIRR VGTVLQLMHT LKYYYWVVNP TDSSGINPKG LDGSRPSQKE IISLRAFMLL
FLKQLILKDR GVKEDELQSI LNYLLTMHED ENIHDVLQLL VALMSEHPAS MIPAFDQRNG
IRVIYKLLAS KSESIRVQAL KVLGYFLKHL GHKRKVEIMH THSLFTLLGE RLMLHTNTLT
VTTYNTLYEI LTEQVCTQVV HKPHPEPDST VKIQNPMILK VVATLLKNST PSSELMEVRR
LFLSDMIKLF SNSRENRRCL LQCSVWQDWM FSLGYINPKS SEEQKITEMV YNIFRILLYH
AIKYEWGGWR VWVDTLSIAH SKVTYEAHKE YLAKMYEEYQ RQEEENIKKG KKGNVSTISG
LSSQAAAVKG GLELREIEDL SQSQSPESET DYPVNADTRD LLIATKISDD SLATSDRPSG
GVRVEVHDLL VDIKAEKVEA TEVKLDDLDL SPETLVGREN GALVEVESLL DNVYSAAVEK
LQNNVHDSVG IIKETEEKDG PLITLADEKE QTTPNNTSFL FDKMTNSDDK LLPELSSSNH
ITLANVQDAH VHLGVNDDLG LLAHMTGSVD LTCAPGVIGD KDFKIHTTAD SLSSITDREL
ASSSKGLDYH QMTATTLEPE TASKSIVNMD AGSTVSDTER SDDGRELGKE IKKIQTTATT
TQAVQGRPLN QHERDLRVDL GFRGMPMTEE QRRQFSPGPR TTMFRIPEFK WSPMHQRLLT
DLLFALETDV HVWRSHSTKS VMDFVNSNEN IIFVHNTIHL ISQMVDNIII ACGGILPLLS
AATSPTTELE NIEVTQGMSS ETAVTFLSRL MAMVDVLVFA SSLNFSEIEA EKNMSSGGLM
RQCLRLVCCV AVRNCLECRQ RQRERGSKPS LGSSKVQDSL QGVTSTASTK TPVDSVPGNL
SPIKDPDRLL QDVDINRLRA VVFRDVDDSK QAQFLALAVV YFISVLMVSK YRDILEPQRE
TARSASQAAR NIRQEINSPT STGNGVTLPP VPDTPALFPD LKEKETPTPT EELHLESSIP
HTDSGIGEEH ISSILNGTDL DACMSPDVMG ELISTLSSDV KKSQESLTES PSELLKPAQS
ISSISQSKGI NVKEILKSLV AAPFEIAETG PDPVPYPDPA LKREAQAILP MQFHSFDRSV
VVPVKKPPPG SLAVNTVGAA SGGGVTPSTT PNIFAATGAT PKSMINTTGA VDSASSSSSS
SSSFVNGATS KNLPAVQTVA PMPEDSAENM SITAKLERAL EKVAPLLREI FVDFAPFLSR
TLLGSHGQEL LIEGLVCMKS STSVVELVML LCSQEWQNSI QKNAGLAFIE LINEGRLLCH
AMKDHIVRVA NEAEFILNRQ RAEDVHKHAE FESQCAQYAA DRREEEKMCD HLISAAKHRD
HVTANQLKQK IVNILTNKHG AWGAISQSQL HDFWRLDYWE DDLRRRRRFV RNAFGSTHSE
ARLKSAIEYG TEEDVMKSKK TFRSQAAVNQ NAETELMLEG DDDAVSLLQE KEIDNLAGPV
VLSTPAQLIA PVIVAKGTLS ITTTEIYFEV DEEDPTFKKI DPKVLGYTEG LHGKWMFSEI
RAVFSRRYLL QNTALEVFMA NRTSVMFNFP DQATVKKVVY SLPRVGVGTS YGLPQARRIS
LATPRQLFKS SNMTQRWQRR EISNFEYLMF LNTIAGRTYN DLNQYPVFPW VLTNYESEEL
DLTLPGNFRD LSKPIGALNP KRAVFYAERY ETWEDDQTPP YHYNTHYSTS LFTLCWLVRI
EPFTTFFLNA NDSKFDHSDR TFSSVARSWR NSQRDTSDVK ELIPEFYYLP EMFVNSNGYN
FGVRDDSVVV NDVDLPPWAK NPEDFVRINR MALESEFVSC QLHQWIDLIF GYKQRGPEAV
RALNVFHYHT YEGSVNLDSV TDPVLREAME AQIHNFGQTP SQLLIEPHPP RSSAMHLCFL
PQSPLMFKDQ MQQDVIMVLK FPSNSPVTHV AANTLPHLTI PAVVTVTCSR LFAVNRWHNT
VGLRGAPGYS LDQAHHLPIE MDSLIANNSG VNKRQITDLV DQSIQINAHC FVVTADNRYI
LVCGFWDKSF RVYSTETGKL TQIVFGHWDV VTCLARSESY IGGDCYIVSG SRDATLLLWY
WSGRHHIIGD NPNNSDYPAP RAVLTGHDHE VVCVSVCAEL GLVISGAKEG PCLVHTITGD
LLRALEGPDL CLYPRLISVS SEGHCIIYYE RGRFCNFSIN GKLLGQMEIN DSTRAILLSS
DGQNLVTGGD NGVVEVWQAC DFKQLYIYPG CDAGIRAMDL SHDQRTLITG MASGSIVAFN
IDFNRWHYEH QNRY
//
