ID F7DPB3_HORSE Unreviewed; 302 AA.
AC F7DPB3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Calponin 1 {ECO:0000313|Ensembl:ENSECAP00000012245.3};
GN Name=CNN1 {ECO:0000313|Ensembl:ENSECAP00000012245.3,
GN ECO:0000313|VGNC:VGNC:56027};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000012245.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000012245.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000012245.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000012245.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000012245.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Thin filament-associated protein that is implicated in the
CC regulation and modulation of smooth muscle contraction. It is capable
CC of binding to actin, calmodulin and tropomyosin. The interaction of
CC calponin with actin inhibits the actomyosin Mg-ATPase activity.
CC {ECO:0000256|ARBA:ARBA00025109}.
CC -!- SIMILARITY: Belongs to the calponin family.
CC {ECO:0000256|ARBA:ARBA00009631}.
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DR AlphaFoldDB; F7DPB3; -.
DR STRING; 9796.ENSECAP00000012245; -.
DR PaxDb; 9796-ENSECAP00000012245; -.
DR Ensembl; ENSECAT00000015253.3; ENSECAP00000012245.3; ENSECAG00000014489.3.
DR VGNC; VGNC:56027; CNN1.
DR GeneTree; ENSGT00940000159680; -.
DR HOGENOM; CLU_055232_0_0_1; -.
DR InParanoid; F7DPB3; -.
DR OMA; GEPTHNH; -.
DR TreeFam; TF313921; -.
DR Proteomes; UP000002281; Chromosome 7.
DR Bgee; ENSECAG00000014489; Expressed in chorionic villus and 19 other cell types or tissues.
DR GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0031032; P:actomyosin structure organization; IEA:InterPro.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001997; Calponin/LIMCH1.
DR InterPro; IPR000557; Calponin_repeat.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR003096; SM22_calponin.
DR PANTHER; PTHR47385; CALPONIN; 1.
DR PANTHER; PTHR47385:SF18; TRANSGELIN; 1.
DR Pfam; PF00402; Calponin; 3.
DR Pfam; PF00307; CH; 1.
DR PRINTS; PR00889; CALPONIN.
DR PRINTS; PR00888; SM22CALPONIN.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR PROSITE; PS01052; CALPONIN_1; 2.
DR PROSITE; PS51122; CALPONIN_2; 3.
PE 1: Evidence at protein level;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F7DPB3};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 68..137
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|Pfam:PF00307"
SQ SEQUENCE 302 AA; 33335 MW; F9A2F02B0FE0CF05 CRC64;
MGRPWKRPGP PPELQKLVRR EEGADGAPAA AQVLSAPATA AHHWPACPLP TSTEAPPTGC
PRRSRTRFIN KLQPGSVKKV NESTQNWHQL ENIGNFIKAI TKYGVKPHDI FEANDLFENT
NHTQVQSTLL ALASMAKTKG NKVNVGVKYA EKQERKFEPE KLREGRNIIG LQMGTNKFAS
QQGMTAYGTR RHLYDPKLGT DQPLDQATIS LQMGTNKGAS QAGMTAPGTK RQIFEPGLGM
EHCDTLNVSL QMGSNKGASQ RGMTVYGLPR QVYDPKYCLT PEYPELGEPA HNHHLHNYYN
SA
//