ID F7DPP5_HORSE Unreviewed; 1042 AA.
AC F7DPP5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=WW and C2 domain containing 1 {ECO:0000313|Ensembl:ENSECAP00000012231.3};
GN Name=WWC1 {ECO:0000313|VGNC:VGNC:25057};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000012231.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000012231.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000012231.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000012231.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000012231.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F7DPP5; -.
DR Ensembl; ENSECAT00000015235.4; ENSECAP00000012231.3; ENSECAG00000014081.4.
DR VGNC; VGNC:25057; WWC1.
DR GeneTree; ENSGT00410000025556; -.
DR TreeFam; TF324040; -.
DR Proteomes; UP000002281; Chromosome 14.
DR Bgee; ENSECAG00000014081; Expressed in oviduct epithelium and 18 other cell types or tissues.
DR ExpressionAtlas; F7DPP5; baseline.
DR CDD; cd08680; C2_Kibra; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037771; C2_WWC.
DR PANTHER; PTHR14791; BOMB/KIRA PROTEINS; 1.
DR PANTHER; PTHR14791:SF22; PROTEIN KIBRA; 1.
DR Pfam; PF00168; C2; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR PROSITE; PS50004; C2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 588..711
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 439..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 754..886
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 94..121
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 224..258
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 290..359
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 932..994
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 450..476
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..779
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 780..801
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 802..818
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 846..886
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1042 AA; 114392 MW; D98314719DD8BDB0 CRC64;
MAAGAGAHAE GLPGGGPGSP ECPEGDLPGE ATAPGACTAG VSAAACRLGA QAGLPGQLSG
DWKSRIRMPA RPGSVISGSS SSSKYDPEIL KAEIATAKSR VNKLKREMVH LQQELQFKER
GFQTLKTIDK KMSDAQGSYK LDEAQAVLRE TKAIKKAITC GEKEKQDLIK SLAMLKDGFR
TDRGSHSDLW SSSSSLESSS FPLSKQYLDV SSQTDISGGC GTSSNNQLAE KVRLRLRYEE
AKRRIANLKI QLAKLDSEAW PGVLDSERDR LILINEKEEL LKEMRFISPR KWTQGEVEQL
EMARKRLEKD LQAARDTQSK ALTERLKFNS KRNQLVRELE EATRQLAALH SQLKSLSSSM
QSLSSGSSPG SLTSSRGSLA ASSLDSSTSA SFTDLYYDPF EQLDSELQSK VEFLLLEGAT
GFRPSGCITT IHEDEVAKTQ KAEGGSRLQA LRSLSGTPKS MTSLSPRSSL SSPSPPCSPL
IADPLLAGDA FLSALEFEDP ELSATLCGLS LGSSTRERCR LEEPGTEGKQ PGQAVNSAPG
CTLKVACVSA AVSDESVAGD SGVYEASVQR LGASEAAAFD SDESEAVGAT RVQIALKYDE
KNKQFAILII QLSNLSALLL QQDQKVNIRV AILPCSESTT CLFRTRPLDA SDALVFNEVF
WVSMSYPALH QKTLRVDVCT TDRSHLEECL GGAQISLAEV CRSGERSTRW YNLLSYKYLK
KQSREPKPVG ATAATPGPES TDAVSALLEQ TAVELEKRQE GRSSTQTLED SWRYEEEASE
NEAAAEEEDG EEEEEGEEDV FAEKASPDMD ECPASKVDKE TNTETPTPSP TVVRPKDRRV
GTPSSGPFLR GSTIIRSKTF SPGPQSQYVC RLNRSDSDSS TLSKKPPFVR NSLERRSVRM
KRPSSVKSVR AERLMRTSLD LELDLQATRT WHSQLTQEIS VLKEFKEQLE QAKSHGEKEL
PQWLREDERF RLLLRMLEKR MDRAEHKGEL QTDKMMRAAA KDVHRLRGQS CKEPPEVQSF
REKMAFFTRP RMNVPALSAD DV
//
