ID F7DQF2_XENTR Unreviewed; 277 AA.
AC F7DQF2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Insulin-like growth factor-binding protein-like 1 {ECO:0000313|Ensembl:ENSXETP00000032269, ECO:0000313|RefSeq:XP_002940304.1};
GN Name=igfbpl1 {ECO:0000313|Ensembl:ENSXETP00000032269,
GN ECO:0000313|RefSeq:XP_002940304.1,
GN ECO:0000313|Xenbase:XB-GENE-484137};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000032269};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000032269}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000032269};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000032269}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_002940304.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_002940304.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_002940304.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_002940304.1; XM_002940258.5.
DR DNASU; 779740; -.
DR Ensembl; ENSXETT00000032269; ENSXETP00000032269; ENSXETG00000014721.
DR GeneID; 100127182; -.
DR KEGG; xtr:100127182; -.
DR AGR; Xenbase:XB-GENE-484137; -.
DR AGR; Xenbase:XB-GENE-994728; -.
DR CTD; 347252; -.
DR Xenbase; XB-GENE-484137; igfbpl1.
DR eggNOG; ENOG502QSKF; Eukaryota.
DR HOGENOM; CLU_075590_0_1_1; -.
DR OMA; WRKVTRS; -.
DR OrthoDB; 3019991at2759; -.
DR TreeFam; TF331645; -.
DR Proteomes; UP000008143; Chromosome 1.
DR Bgee; ENSXETG00000014721; Expressed in brain and 5 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005520; F:insulin-like growth factor binding; IEA:InterPro.
DR GO; GO:0001558; P:regulation of cell growth; IEA:InterPro.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 4.10.40.20; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR011390; IGFBP_rP_mac25.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR PANTHER; PTHR14186; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR14186:SF16; INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-LIKE 1; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR SMART; SM00121; IB; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00280; KAZAL; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..277
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041197393"
FT DOMAIN 25..106
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 111..150
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 152..258
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 277 AA; 29740 MW; 1DAECB0E41D94E0B CRC64;
MQLFVVLLPL FLCFQKTPGV GAFVSLSACG HCNEDFCDSV TCAAPELLTK DECGCCDRCL
SVEGEVCGGQ DESRARCAPG MVCVSRPSFG TGASSFSDGT GVCLCEEDGA VCGSDGRTYS
SACVLRLQSW KSQHQGTGSI HKTHDGECKF APLIIASPRK IRNVTGSQVY LSCEVKAVPT
PIITWKKVTE SPQGIKLFEE LPGDRINVAV QVRGGPSRHE CTGWVMISPL TKEDEGTYQC
HATNMVGETW ADGSIKVTEH NARRIKRRNH GGSASKV
//
