ID F7DRS2_HORSE Unreviewed; 406 AA.
AC F7DRS2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 4.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Corticosteroid-binding globulin {ECO:0000256|ARBA:ARBA00039186};
DE AltName: Full=Serpin A6 {ECO:0000256|ARBA:ARBA00043180};
DE AltName: Full=Transcortin {ECO:0000256|ARBA:ARBA00041777};
GN Name=SERPINA6 {ECO:0000313|Ensembl:ENSECAP00000012843.4,
GN ECO:0000313|VGNC:VGNC:22845};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000012843.4, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000012843.4, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000012843.4,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000012843.4}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000012843.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Major transport protein for glucocorticoids and progestins in
CC the blood of almost all vertebrate species.
CC {ECO:0000256|ARBA:ARBA00037222}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the serpin family.
CC {ECO:0000256|RuleBase:RU000411}.
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DR AlphaFoldDB; F7DRS2; -.
DR STRING; 9796.ENSECAP00000012843; -.
DR MEROPS; I04.954; -.
DR PaxDb; 9796-ENSECAP00000012843; -.
DR Ensembl; ENSECAT00000015928.4; ENSECAP00000012843.4; ENSECAG00000015152.4.
DR VGNC; VGNC:22845; SERPINA6.
DR GeneTree; ENSGT00940000161611; -.
DR HOGENOM; CLU_023330_2_1_1; -.
DR InParanoid; F7DRS2; -.
DR OMA; HDSELPC; -.
DR TreeFam; TF343201; -.
DR Proteomes; UP000002281; Chromosome 24.
DR Bgee; ENSECAG00000015152; Expressed in liver and 7 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR GO; GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
DR GO; GO:0008211; P:glucocorticoid metabolic process; IEA:Ensembl.
DR CDD; cd19554; serpinA6_CBG; 1.
DR Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR InterPro; IPR023795; Serpin_CS.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461:SF34; CORTICOSTEROID-BINDING GLOBULIN; 1.
DR PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR Pfam; PF00079; Serpin; 1.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; Serpins; 1.
DR PROSITE; PS00284; SERPIN; 1.
PE 1: Evidence at protein level;
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F7DRS2};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Steroid-binding {ECO:0000256|ARBA:ARBA00022665};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..406
FT /note="Corticosteroid-binding globulin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040392536"
FT DOMAIN 47..394
FT /note="Serpin"
FT /evidence="ECO:0000259|SMART:SM00093"
SQ SEQUENCE 406 AA; 45329 MW; 4A57293D7B28597B CRC64;
MLLGLSTCLL WLSTSGLWTI QAEDPDGDMS IRIPHRDLAP SNVDFAFSLY KHLVVSAPGR
DVFISPVSIS TALAMLSLGT RGHTQIRLLQ GLGFNLTEMS EARIHQGFQH LHHVLVESET
TSDILMGNTL FFDHSLELLE SFSADTERYY ELEALATDFQ DQAIASRQIN EYLKNKTQGK
IADLFLEPDS PAMLILVNYI FFKGAWAQPF NPESTREEDF YVNETTVVKV PMMSQSSTMN
YLNDPVLSCQ LVQLDYTSNG TVFFILPEKG KIDIVIDALS RSTLGRWEMS LTRSSHVDLH
VPKLFLSSTY DLGDILRDRG IADFSGISQE GRLKVVHKAA LHLDEKGEES AAPTGIPPNV
GSKPLTIRFN RPFIILVFDH FTWSSLFLVK VVNPTEGPAP RSHPAV
//
