ID F7DS18_ORNAN Unreviewed; 856 AA.
AC F7DS18;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Dimethylglycine dehydrogenase {ECO:0000313|Ensembl:ENSOANP00000012580.3};
GN Name=DMGDH {ECO:0000313|Ensembl:ENSOANP00000012580.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000012580.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000012580.3, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000012580.3,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000012580.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000012580.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GcvT family.
CC {ECO:0000256|ARBA:ARBA00008609}.
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DR AlphaFoldDB; F7DS18; -.
DR STRING; 9258.ENSOANP00000012580; -.
DR Ensembl; ENSOANT00000012582.3; ENSOANP00000012580.3; ENSOANG00000007898.3.
DR eggNOG; KOG2844; Eukaryota.
DR GeneTree; ENSGT00940000158176; -.
DR HOGENOM; CLU_007884_11_1_1; -.
DR TreeFam; TF314735; -.
DR Proteomes; UP000002279; Chromosome 1.
DR Bgee; ENSOANG00000007898; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 2.40.30.110; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 3.30.70.1400; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR006076; FAD-dep_OxRdtase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR032503; FAO_M.
DR InterPro; IPR028896; GCST/YgfZ/DmdA.
DR InterPro; IPR013977; GCV_T_C.
DR InterPro; IPR006222; GCV_T_N.
DR InterPro; IPR029043; GcvT/YgfZ_C.
DR InterPro; IPR027266; TrmE/GcvT_dom1.
DR PANTHER; PTHR43757; AMINOMETHYLTRANSFERASE; 1.
DR PANTHER; PTHR43757:SF2; AMINOMETHYLTRANSFERASE, MITOCHONDRIAL; 1.
DR Pfam; PF01266; DAO; 1.
DR Pfam; PF16350; FAO_M; 1.
DR Pfam; PF01571; GCV_T; 1.
DR Pfam; PF08669; GCV_T_C; 1.
DR SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF103025; Folate-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT DOMAIN 43..405
FT /note="FAD dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF01266"
FT DOMAIN 408..460
FT /note="FAD dependent oxidoreductase central"
FT /evidence="ECO:0000259|Pfam:PF16350"
FT DOMAIN 471..735
FT /note="Aminomethyltransferase folate-binding"
FT /evidence="ECO:0000259|Pfam:PF01571"
FT DOMAIN 761..838
FT /note="Glycine cleavage T-protein C-terminal barrel"
FT /evidence="ECO:0000259|Pfam:PF08669"
SQ SEQUENCE 856 AA; 95940 MW; 00139B7D2A6F33D3 CRC64;
MSYLPPFLPD LTKKRSTLKS CDVGRKENQF SISETKWKDA AETVIIGGGC VGVSLAYHLA
KAGMKDVVLL EKSELTAGST WHAAGLTTYF HPGINLKKIH YYSIKLYEKL EEETGQVVGF
HQPGSIRIAT TPTRVDEFKY QMTRTRWHPT EQYLIEPEKV QEMFPLLNME KVLAGLYNPG
DGHIDPYSLT MALAAGARRY GALLKFPAPV TGLKPRSDGT WEVETSQGTI RAKRVVNASG
FWAREVGKMI GLQHPLIPVH HQYVVTSTIP EVKALKRELP VLRDLEGSYY LRQERDGLLF
GPYESQEKMK LQSSWVTDGV PPGFGKELFE SDLDRIMEHV EAAMEMVPVL KKADIINIVS
GPITYSPDIL PMVGPHQGVR NYWVAIGFGY GIIHAGGVGK YLSDWILDGE PPFDLIELDP
NRYGKWTTPQ YTEVKARESY GFNNIVGYPK EERFAGRPTE RVSGIYDVLK SKCSMGFHAG
WEQPHWFYQP GHEAGYKPSF RRTNWFEPVG SEYKQVMQKV GVIDLSPFGK FNVRGKESVK
LLDRLFANVI PKVGFTNISH MITPRGRVYA ELTVCQKSPG EFLLITGSGS ELHDLRWIEE
EAASGGFDVE IRNVTDELGV LGVAGPRARK VLEKLTSEDL SDAAFKFLQA KPLKISNVPV
TAIRISYTGE LGWELYHRRE DSAILYDAIM TAGQEEEIDN FGIYAMNVLR LEKAFRAWGS
EMNCDTNPLE AGLDHFIKLN KAADFIGKQA LKQIKEKGLK RQLVCLTLET DNVDPEGNES
IWHNGKVVGN TTSGTYSYSA QKSLAFAYVP VELSKVGQKV EVELLGKNYP AVIIREPLVL
TEPTRNRLQK KGQSGM
//
