ID F7DSF6_XENTR Unreviewed; 687 AA.
AC F7DSF6;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Platelet-derived growth factor receptor-like protein {ECO:0000256|ARBA:ARBA00019671};
GN Name=flt1 {ECO:0000313|Ensembl:ENSXETP00000025792,
GN ECO:0000313|RefSeq:XP_002934078.1,
GN ECO:0000313|Xenbase:XB-GENE-6495121};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000025792};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000025792}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000025792};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000025792}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_002934078.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_002934078.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_002934078.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Forms a complex composed of PDGFRL, TNK2 and GRB2.
CC {ECO:0000256|ARBA:ARBA00011360}.
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DR RefSeq; XP_002934078.1; XM_002934032.4.
DR Ensembl; ENSXETT00000025792; ENSXETP00000025792; ENSXETG00000011791.
DR GeneID; 100492992; -.
DR KEGG; xtr:100492992; -.
DR AGR; Xenbase:XB-GENE-6495121; -.
DR CTD; 2321; -.
DR Xenbase; XB-GENE-6495121; flt1.
DR eggNOG; KOG0200; Eukaryota.
DR HOGENOM; CLU_400039_0_0_1; -.
DR OMA; FNRGLFC; -.
DR OrthoDB; 5320006at2759; -.
DR TreeFam; TF325768; -.
DR Proteomes; UP000008143; Chromosome 2.
DR Bgee; ENSXETG00000011791; Expressed in heart and 8 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0005021; F:vascular endothelial growth factor receptor activity; IEA:InterPro.
DR GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IEA:InterPro.
DR CDD; cd00096; Ig; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR042495; PDGFRL.
DR InterPro; IPR009135; VEGFR1_rcpt.
DR PANTHER; PTHR15360:SF2; MACROPHAGE COLONY-STIMULATING FACTOR 1 RECEPTOR; 1.
DR PANTHER; PTHR15360; PLATELET-DERIVED GROWTH FACTOR RECEPTOR LIKE; 1.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF00047; ig; 2.
DR Pfam; PF21339; VEGFR-1-like_Ig-like; 1.
DR PRINTS; PR01832; VEGFRECEPTOR.
DR PRINTS; PR01833; VEGFRECEPTR1.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Receptor {ECO:0000313|RefSeq:XP_002934078.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..687
FT /note="Platelet-derived growth factor receptor-like
FT protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041117108"
FT DOMAIN 31..122
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 217..323
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 334..401
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 425..553
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 556..654
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 664..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 666..680
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 687 AA; 77345 MW; D32DB812842A67DD CRC64;
MISCATVAML CLLFGCLLLT GHSDGSKLKS PKLNIKEKEI VIEAGQPIHL SCSSHRSHVW
IFPANLNKES DRIRITNSAC GGHPRTMCSS LTVHKAQPSD TGYYSCTVAM KNGNRSTSVY
IFVADVNIPF VEMNTEFPKI VHVADGEELV IPCRVTSPNI TVTFKRYGKH PFPVDQKNII
WNNKRGIIIP NPTFQYSDLL SCEATLNGIV HNTIYLPHKQ SSKIHSVKLD VPDSIHLLSG
DQLRIQCSVK TDLNARAEIE WKYPRTKFHR MAFIRRKMDA TNSKVLVFYS TLIIDDVRKF
DEGQYSCTAK NGPSTSSVNT TVRIHAKAFI NVKPRTQGTL ETFAGQKSYP ILVKVRAFPE
PEVIWLKDGL PALEKCTRYR DSDKYSLTIK DVSEEDAGKY TIVLKLKQWN LTKNLTLPLV
VNVRPQIYEN SVSVQEPVLY PLGSKQSLTC TVFGIPPPTI TWHWRPCLNK NPKMRCDFPT
DSSRYSLPLT VGHNSSSLGN TIHSIRERTQ MIEGKNKTAG TISIDNSRVS GIYTCMATNK
LGSERREMMY YVTDIPNGFH ISLNKVPAEG DDFKLTCSVS KFMYTDITWI LFRTVGNRTI
HHSISKQRNA IITAHSLILT AIIKNANVSD SGVYACRAKN LYTGKFLLQR KEINITGEHN
SKKTVVSRTS KLKRRKRNST TQSLVTH
//
