ID F7DT63_CALJA Unreviewed; 1190 AA.
AC F7DT63;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 4.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=leucine--tRNA ligase {ECO:0000256|ARBA:ARBA00013164};
DE EC=6.1.1.4 {ECO:0000256|ARBA:ARBA00013164};
DE AltName: Full=Leucyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030520};
GN Name=LARS1 {ECO:0000313|Ensembl:ENSCJAP00000039714.5};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000039714.5, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000039714.5}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000039714.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F7DT63; -.
DR STRING; 9483.ENSCJAP00000039714; -.
DR Ensembl; ENSCJAT00000041957.5; ENSCJAP00000039714.5; ENSCJAG00000021314.5.
DR eggNOG; KOG0437; Eukaryota.
DR GeneTree; ENSGT00390000012163; -.
DR InParanoid; F7DT63; -.
DR OMA; KFIEWQF; -.
DR TreeFam; TF105718; -.
DR Proteomes; UP000008225; Chromosome 2.
DR Bgee; ENSCJAG00000021314; Expressed in ovary and 6 other cell types or tissues.
DR GO; GO:0017101; C:aminoacyl-tRNA synthetase multienzyme complex; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004819; F:glutamine-tRNA ligase activity; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR GO; GO:0004823; F:leucine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0071233; P:cellular response to leucine; IEA:Ensembl.
DR GO; GO:1990253; P:cellular response to leucine starvation; IEA:Ensembl.
DR GO; GO:0006425; P:glutaminyl-tRNA aminoacylation; IEA:Ensembl.
DR GO; GO:0006429; P:leucyl-tRNA aminoacylation; IEA:Ensembl.
DR GO; GO:1904263; P:positive regulation of TORC1 signaling; IEA:Ensembl.
DR GO; GO:0008361; P:regulation of cell size; IEA:Ensembl.
DR CDD; cd07959; Anticodon_Ia_Leu_AEc; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.90.740.10; Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain; 1.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR004493; Leu-tRNA-synth_Ia_arc/euk.
DR InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR NCBIfam; TIGR00395; leuS_arch; 1.
DR PANTHER; PTHR45794:SF1; LEUCINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR PANTHER; PTHR45794; LEUCYL-TRNA SYNTHETASE; 1.
DR Pfam; PF08264; Anticodon_1; 1.
DR Pfam; PF00133; tRNA-synt_1; 2.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363035};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363035};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363035};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT DOMAIN 20..103
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 189..738
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 808..921
FT /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT anticodon-binding"
FT /evidence="ECO:0000259|Pfam:PF08264"
SQ SEQUENCE 1190 AA; 136284 MW; 16597E870DC8DB75 CRC64;
MAERKGTAKV DFLKKIEKEI QQKWDTERVF EMNASNLEKQ TNKGKYFVTF PYPYMNGRLH
LGHTFSLSKC EFAVGYQRLK GKCCLFPFGL HCTGMPIKAC ADKLKREIEL YGCPPDFPDE
EEEEEETNVK TEDTIIKDKA KGKKSKAAAK AGSSKYQWGI MKSLGLSDEE IVRFSEAEHW
LDYFPPLALR DLKRMGLKVD WRRSFITTDV NPYYDSFVRW QFLTLRERNK IKFGKRYTIY
SPKDGQPCMD HDRQTGEGVG PQEYTLVKLK VLEPYPSKLS GLKGKNIFLV AATLRPETMF
GQTNCWVRPD MKYIGFETVN GDIFICTQRA ARNMSYQGFT KDNGVVPVVK ELMGEEILGA
SLSAPLTSYK VIYVLPMLTI KEDKGTGVVT SVPSDSPDDN AALRDLKKKQ ALRAKYGIRD
DMVLPFEPVP VIEIPGFGNL SAVTICDELK IQSQNDREKL AEAKEKLYLK GFYDGVMLVD
GFKGQKVQDV KKTIQKKMID TGDALIYMEP EKEVMSRSSD ECVVALCDQW YLDYGEENWK
KQTSQCLKNL ETFCEETRRN FEATLGWLQE HACSRTYGLG TRLPWDEQWL IESLSDSTIY
MAFYTVAHLL QGDDLHGQAE SPLGIRPQQM TKEVWDYVFF KEAPFPKTQI PKEKLDQLKH
EFEFWYPVDL RVSGKDLVPN HLTYYLYNHV AMWPEQSDKW PRAVRANGHL LLNSEKMSKS
TGNFLTLTQA IDKFSADGFG VHEQSMRDSC VGMRLALADA GDTVEDANFV ETMADAGILR
LYTWVEWVKE MVANWDSLRS GPADTFNDRV FASELNAGII KTDQNYEKMM FKEALKTGFF
EFQAAKDKYR ELAVEGMHRE LVFRFIEVQT LLLAPFCPHL CEHIWTLLGK PNSIMNASWP
VAGPVDEVLI RSSQYLMEVT HDLRLRLKTY MMPAKGKKTD KQPLQKPSHC TIYVAKTYPP
WQHTALSVLR KHFEANNGKL PDNKVIASEL GSMPELKKYM KKVMPFVAMI KENLEKVGPR
VLDLQLEFDE KAVLMENIVY LTNSLELEHI EVKFASEAED KVTEDCCPGK PLNVFRIEPG
VSVSLVNPQP SNGHFSTKIE IRQGDNCDSI IRRLMKMNRG IKDLSKVKLM RFDDPLWGPR
RVPVLGKEHT EKTPISEHAV FDVDLMSKKI HLTENGIRVD IGDTIIYLVH
//
