ID F7DVE4_HORSE Unreviewed; 488 AA.
AC F7DVE4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=SPEM family member 2 {ECO:0000313|Ensembl:ENSECAP00000002037.3};
GN Name=SPEM2 {ECO:0000313|VGNC:VGNC:56493};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000002037.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000002037.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000002037.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000002037.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000002037.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
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DR AlphaFoldDB; F7DVE4; -.
DR STRING; 9796.ENSECAP00000002037; -.
DR PaxDb; 9796-ENSECAP00000002037; -.
DR Ensembl; ENSECAT00000002845.4; ENSECAP00000002037.3; ENSECAG00000003006.4.
DR VGNC; VGNC:56493; SPEM2.
DR GeneTree; ENSGT00510000049558; -.
DR HOGENOM; CLU_884385_0_0_1; -.
DR InParanoid; F7DVE4; -.
DR OMA; DVHIHCT; -.
DR TreeFam; TF337389; -.
DR Proteomes; UP000002281; Chromosome 11.
DR Bgee; ENSECAG00000003006; Expressed in testis and 2 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR031368; SPEM1_N.
DR PANTHER; PTHR34834:SF2; SPEM FAMILY MEMBER 2; 1.
DR PANTHER; PTHR34834; SPERMATID MATURATION PROTEIN 1; 1.
DR Pfam; PF15670; Spem1; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..248
FT /note="Spermatid maturation protein 1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF15670"
FT REGION 263..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 325..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 404..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..479
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 488 AA; 55651 MW; 41F3D0EA2DA76B39 CRC64;
MENQLWYNTL GCCNQYQEGP QEAEDFLLLL LGLIILVNIG INMATVMWHG LQNVLDKTIC
WINQKNEILQ ACESSPKDSP PKAQDVHIYC TLDPVQVKMA RPTCYSSSSY HHIRNHARCR
HRRCYRRSRS HQQRLKNPTQ CPHNRSVFRS QHCSRKMSQL RPMPCFDGEG LDSYLEEEDD
LSFPYPKYPR RGWGGLYQRM GLPSPMRLWG RQGGILASLP PPSLYLSPEL RCMPKRVEAK
SELRLQSYRP HCSQSRIWGN METEQWTSSP PPPRQLLRNP SWVPGGHSPY SSGGQLLYDS
WDQRRRALEG SEPPCVLVRR VSRAEAREPY SPQSHRRSLP SHAYSQPNRS PHPSTGHLSY
SSRDPQEVRR RAAEWAEALP ARHPLTTSTS LTVLGEASYQ RAPAPSPALL SRSSQRLPEV
QAAELSPPPP TFVPLRRNPG GNTNHQVYDS LELKRQVQES RARANSLPPP STSASRPSVH
RSRMGKFN
//
