ID F7DXD2_HORSE Unreviewed; 580 AA.
AC F7DXD2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Cytochrome P450 family 27 subfamily A member 1 {ECO:0000313|Ensembl:ENSECAP00000017395.3};
GN Name=CYP27A1 {ECO:0000313|Ensembl:ENSECAP00000017395.3,
GN ECO:0000313|VGNC:VGNC:50564};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000017395.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000017395.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017395.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000017395.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017395.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971};
CC -!- PATHWAY: Hormone biosynthesis. {ECO:0000256|ARBA:ARBA00004972}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004637};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004637}.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR AlphaFoldDB; F7DXD2; -.
DR Ensembl; ENSECAT00000021139.3; ENSECAP00000017395.3; ENSECAG00000019737.3.
DR CTD; 1593; -.
DR VGNC; VGNC:50564; CYP27A1.
DR GeneTree; ENSGT00950000182905; -.
DR HOGENOM; CLU_001570_28_3_1; -.
DR OrthoDB; 2658719at2759; -.
DR TreeFam; TF105094; -.
DR Proteomes; UP000002281; Chromosome 6.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0047749; F:cholestanetriol 26-monooxygenase activity; IEA:Ensembl.
DR GO; GO:0031073; F:cholesterol 26-hydroxylase activity; IEA:Ensembl.
DR GO; GO:0020037; F:heme binding; IEA:Ensembl.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0030343; F:vitamin D3 25-hydroxylase activity; IEA:Ensembl.
DR GO; GO:0006699; P:bile acid biosynthetic process; IEA:Ensembl.
DR GO; GO:0006707; P:cholesterol catabolic process; IEA:Ensembl.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24279; -; 1.
DR PANTHER; PTHR24279:SF118; CYTOCHROME P450 FAMILY 27 SUBFAMILY A MEMBER 1; 1.
DR Pfam; PF00067; p450; 2.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|RuleBase:RU000461};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU000461};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Steroidogenesis {ECO:0000256|ARBA:ARBA00023250};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
SQ SEQUENCE 580 AA; 65189 MW; 3E31D087F2F265F6 CRC64;
MAALCCARMR WALLGTRVAR SGLGPQGARA KATIPAALPE AQAAEAPGTG PGDRRLRSLE
QLPGPGQLRA LFQMLGQGYV LYSHELQVLN KAKYGPIWIT HLGLRSYINL ASAPLLEQVM
RQEGKYPVRD YMELWKAHRD LHGLAYGPFT TEGESWYRLR QALNQRLLKP TEAALYTDAL
NEVIDDFMVR LSQLRAESAS GDQVPDIAHH FYHFALEAIS YILFEKRIGC LERSIPQDTR
TFIRSIDLMF KNSVYSTILP KWTRSVLPFW KRYLDGWNTI FSFGKKLIDQ KLEEIEAQLQ
TGGPDGVQIS GYLHFLLTSG QLSPHEAMGS LPELLLAGVD TVGEGGQRGD QGLPAPILNQ
FPIIPHLSLI FVPPEIPPHF VSHSTSQTSN TLTWALYHLS KHPEIQAALH KEVMGVVPAG
QVPQHKDFAH MPLLKAVLKE TLRLYPVVPV NSRVITEKEI EVGGFFFPKN TQFVLCHYVA
SRDPSIFPEP ESFRPERWLR KSQTDTLRVQ HPFGSVPFGY GVRACLGRRI AELEMQLLLT
RLIQQYEVAL APETGEVKSM ARVVLVPSKK VGLRFLQRQC
//
