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Database: UniProt
Entry: F7DXU3_HORSE
LinkDB: F7DXU3_HORSE
Original site: F7DXU3_HORSE 
ID   F7DXU3_HORSE            Unreviewed;      1107 AA.
AC   F7DXU3;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   05-JUN-2019, entry version 56.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   Name=POLD1 {ECO:0000313|Ensembl:ENSECAP00000005397,
GN   ECO:0000313|VGNC:VGNC:21651};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000005397, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000005397, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000005397,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000005397}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000005397};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
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DR   RefSeq; XP_001493912.1; XM_001493862.4.
DR   PaxDb; F7DXU3; -.
DR   Ensembl; ENSECAT00000007403; ENSECAP00000005397; ENSECAG00000006077.
DR   VGNC; VGNC:21651; POLD1.
DR   eggNOG; KOG0968; Eukaryota.
DR   eggNOG; COG0417; LUCA.
DR   GeneTree; ENSGT00560000077365; -.
DR   InParanoid; F7DXU3; -.
DR   OMA; CLVNYTE; -.
DR   TreeFam; TF352785; -.
DR   Proteomes; UP000002281; Chromosome 10.
DR   Bgee; ENSECAG00000006077; Expressed in 3 organ(s), highest expression level in liver.
DR   GO; GO:0043625; C:delta DNA polymerase complex; IBA:GO_Central.
DR   GO; GO:0008296; F:3'-5'-exodeoxyribonuclease activity; IBA:GO_Central.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006287; P:base-excision repair, gap-filling; IBA:GO_Central.
DR   GO; GO:0045004; P:DNA replication proofreading; IBA:GO_Central.
DR   GO; GO:0006261; P:DNA-dependent DNA replication; IBA:GO_Central.
DR   GO; GO:0006297; P:nucleotide-excision repair, DNA gap filling; IBA:GO_Central.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      131    477       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      541    973       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN     1012   1082       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION        1     71       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F7DXU3}.
FT   COMPBIAS     42     56       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                F7DXU3}.
SQ   SEQUENCE   1107 AA;  123477 MW;  5B995FE2F9FD0EB4 CRC64;
     MEGKRRPGPG PGVPPKRARG GLWDEDEPSG PSQFEEELAL MEELEAERRL QEQEEEELQS
     ALEGATHGQL SQTAIDPRWL RPSPPPLDPQ TEPLIFQQLE IDHYVGPAQP LPGAPTPSPG
     SVPVLRAFGV TDEGVSVCCH IHGFAPYFYT PAPPGFGPEH LSDLQRELNV AISRDQRGGK
     ELAGPAVLAV ELCSRESMFG YQGHGPSPFL RITLALPRLM APARRLLEQG IRVAGLGTPS
     FAPYEANVDF EIRFMVDTDI VGCNWLELPA GKYVLRPKGK TTLCQLEADV LWSDVISHAP
     EGQWQRIAPL RVLSFDIECA GRKGIFPEPE RDPVIQICSL GLRWGEPEPF LRLALTLRPC
     APILGAKVQS YEREEELLQA WSAFIRTMDP DVITGYNIQN FDLPYLISRA QTLKVSSFPF
     LGRVSGLRSN IRDSSFQSKQ TGRRDTKVVS MVGRVQMDML QVLLREYKLR SYTLNAVSFH
     FLGEQKEDVQ HSIITDLQNG NEQTRRRLAV YCLKDAFLPL RLLERLMVLV NAVEMARVTG
     VPLSYLLSRG QQVKVVSQLL RQAMREGLVM PVVKTEGGED YTGATVIEPL KGYYDVPIAT
     LDFSSLYPSI MMAHNLCYTT LLRPGAAQKL GLTEDQFIKT PTGDEFVKTS VRKGLLPQIL
     ENLLSARKRA KAELAKETDP LRRQVLDGRQ LALKVSANSV YGFTGAQVGK LPCLEISQSV
     TGFGRQMIER TKQLVESKYT TENGYSASAK VVYGDTDSVM CRFGVSSVAE AMALGREAAD
     WVSGHFPSPI RLEFEKVYFP YLLISKKRYA GLLFSSRPDA HDRMDCKGLE AVRRDNCPLV
     ANLVTASLRR LLIDRDPNGA VAHAQEVISD LLCNRIDISQ LVITKELTRA AADYAGKQAH
     VELAERMRKR DPGSAPSLGD RVPYVIIGAA KGVAAYMKSE DPLFVLEHSL PIDTQYYLEQ
     QLAKPLLRIF EPILGEGRAE AVLLRGDHTR CKTVLTGKVG GLLAFAQRRS CCIGCRTVLS
     HQGAVCKFCQ PRESELYQKE VSHLNALEER FSRLWTQCQR CQGSLHEDVI CTSRDCPIFY
     MRKKVRKDLE DQEQLLRRFG PPGPEAW
//
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