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Database: UniProt
Entry: F7DYJ5_HORSE
LinkDB: F7DYJ5_HORSE
Original site: F7DYJ5_HORSE 
ID   F7DYJ5_HORSE            Unreviewed;       528 AA.
AC   F7DYJ5;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2023, sequence version 3.
DT   24-JAN-2024, entry version 75.
DE   RecName: Full=Carboxylic ester hydrolase {ECO:0000256|RuleBase:RU361235};
DE            EC=3.1.1.- {ECO:0000256|RuleBase:RU361235};
GN   Name=ACHE {ECO:0000313|Ensembl:ENSECAP00000005091.3,
GN   ECO:0000313|VGNC:VGNC:111780};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000005091.3, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000005091.3, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000005091.3,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA   Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA   Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA   Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA   Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA   Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA   Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA   Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA   Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000005091.3}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000005091.3};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC       Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004170}. Synapse
CC       {ECO:0000256|ARBA:ARBA00034103}.
CC   -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC       {ECO:0000256|ARBA:ARBA00005964, ECO:0000256|RuleBase:RU361235}.
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DR   AlphaFoldDB; F7DYJ5; -.
DR   ESTHER; horse-ACHE; ACHE.
DR   MEROPS; S09.979; -.
DR   Ensembl; ENSECAT00000007046.4; ENSECAP00000005091.3; ENSECAG00000006898.4.
DR   KEGG; ecb:100069149; -.
DR   CTD; 43; -.
DR   VGNC; VGNC:111780; ACHE.
DR   GeneTree; ENSGT00940000157637; -.
DR   HOGENOM; CLU_006586_13_0_1; -.
DR   OrthoDB; 4386at2759; -.
DR   TreeFam; TF315470; -.
DR   Proteomes; UP000002281; Chromosome 13.
DR   Bgee; ENSECAG00000006898; Expressed in bone marrow and 18 other cell types or tissues.
DR   ExpressionAtlas; F7DYJ5; baseline.
DR   GO; GO:0004104; F:cholinesterase activity; IEA:InterPro.
DR   CDD; cd00312; Esterase_lipase; 1.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 2.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002018; CarbesteraseB.
DR   InterPro; IPR019826; Carboxylesterase_B_AS.
DR   InterPro; IPR019819; Carboxylesterase_B_CS.
DR   InterPro; IPR000997; Cholinesterase.
DR   PANTHER; PTHR43918; ACETYLCHOLINESTERASE; 1.
DR   PANTHER; PTHR43918:SF11; ACETYLCHOLINESTERASE; 1.
DR   Pfam; PF00135; COesterase; 2.
DR   PRINTS; PR00878; CHOLNESTRASE.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   PROSITE; PS00122; CARBOXYLESTERASE_B_1; 1.
DR   PROSITE; PS00941; CARBOXYLESTERASE_B_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361235};
KW   Membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Neurotransmitter degradation {ECO:0000256|ARBA:ARBA00022867};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Serine esterase {ECO:0000256|ARBA:ARBA00022487};
KW   Signal {ECO:0000256|RuleBase:RU361235};
KW   Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000256|RuleBase:RU361235"
FT   CHAIN           32..528
FT                   /note="Carboxylic ester hydrolase"
FT                   /evidence="ECO:0000256|RuleBase:RU361235"
FT                   /id="PRO_5040530938"
FT   DOMAIN          40..351
FT                   /note="Carboxylesterase type B"
FT                   /evidence="ECO:0000259|Pfam:PF00135"
FT   DOMAIN          355..475
FT                   /note="Carboxylesterase type B"
FT                   /evidence="ECO:0000259|Pfam:PF00135"
SQ   SEQUENCE   528 AA;  57701 MW;  1C0DE3AA0D76A539 CRC64;
     MRPPRCPLHS PSLASPLLLL LLFLLGGGAE AEGPEDPELL VTVREGRLRG IRLMAPGGPV
     SAFLGIPFAE PPVGPRRFLP PEPKRPWPGV LDATAFQSVC YQYVDTLYPG FKGTEMWNPN
     RELSEDCLYL NVWTPYPRPA SPTPVLIWIY GGGFYSGASS LDVYDGRFLT QAEGTVLVSM
     NYRVGAFGFL ALPGSREAPG NVGLLDQRLA LQWVQENVAA FGGDPTSVTL FGESAGAASV
     GMHLLSPPSR GLFHRAVLQS GAPNGPWATV GVGEARRRAT LLARLVGCPL GGTGGNDTEL
     VACLRTRPAQ DLVDHEWHVL PQESVFRFSF VPVVDGDFLS DTPEALINAG DFHSLQLAGR
     LAAQGARVYA YIFEHRASTL SWPLWMGVPH GYEIEFIFGL PLEPSLNYTI EERTFAQRLM
     RYWANFARTG DPNDPRELKA PQWPPYTAGA QQYVSLNLRP LEVRRGLRAQ ACAFWNRFLP
     KLLSATASEA PSTCPGPAHG EAAPRPRPGL PLPLLLLLFL LLSWLPRL
//
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