ID F7E295_CALJA Unreviewed; 498 AA.
AC F7E295;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Thymocyte selection associated high mobility group box {ECO:0000313|Ensembl:ENSCJAP00000047954.3};
GN Name=TOX {ECO:0000313|Ensembl:ENSCJAP00000047954.3};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000047954.3, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000047954.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000047954.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; F7E295; -.
DR Ensembl; ENSCJAT00000061405.4; ENSCJAP00000047954.3; ENSCJAG00000008958.5.
DR GeneTree; ENSGT00940000159497; -.
DR HOGENOM; CLU_088603_0_0_1; -.
DR Proteomes; UP000008225; Chromosome 16.
DR Bgee; ENSCJAG00000008958; Expressed in frontal cortex and 3 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd21995; HMG-box_TOX-like; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR PANTHER; PTHR45781; AGAP000281-PA; 1.
DR PANTHER; PTHR45781:SF4; THYMOCYTE SELECTION-ASSOCIATED HIGH MOBILITY GROUP BOX PROTEIN TOX; 1.
DR Pfam; PF00505; HMG_box; 1.
DR PRINTS; PR00886; HIGHMOBLTY12.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT DOMAIN 233..301
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 233..301
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 119..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 164..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..218
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 498 AA; 54550 MW; 0FBDBD941B2B068D CRC64;
MERQPGFDGE NMYMSMTEPS QDYVPASQSY PGPSLESEDF NIPPITPPSL PDHSLVHLNE
VESGYHSLCH PMNHNGLLPF HPQNMDLPEI TVSNMLGQDG ALLSNSISVM QDIRNAEGTQ
YSSHPQMAAM RPRGQPADIR QQPGIMPHSQ LTTINQSQLS AQLGLNMGGS NVPHNSPSPP
GSKSATPSPS SSVHEDEGDD TSKINGGEKR PASDMGKKPK TPKKKKKKDP NEPQKPVSAY
ALFFRDTQAA IKGQNPNATF GEVSKIVASM WDGLGEEQKQ VYKKKTEAAK KEYLKQLAAY
RASLVSKSYS EPVDVKTSQP PQLINSKPSV FHGPSQAHSA LYLSSHYHQQ PGMNPHLTAM
HPSLPRNIAP KPNNQMPVTV SIANMAVSPP PPLQISPPLH QHLNMQQHQP LTMQQPLGNQ
LPMQVQSALH SPTMQQGFTL QPDYQTIINP TSTAAQVVTQ AMEYVRSGCR NPPPQPVDWN
NDYCSSGGMQ RDKALYLT
//
