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Database: UniProt
Entry: F7E2D6_XENTR
LinkDB: F7E2D6_XENTR
Original site: F7E2D6_XENTR 
ID   F7E2D6_XENTR            Unreviewed;       837 AA.
AC   F7E2D6;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   05-JUN-2019, entry version 59.
DE   SubName: Full=Ral guanine nucleotide dissociation stimulator {ECO:0000313|Ensembl:ENSXETP00000013734};
GN   Name=ralgds {ECO:0000313|Ensembl:ENSXETP00000013734,
GN   ECO:0000313|Xenbase:XB-GENE-987988};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000013734, ECO:0000313|Proteomes:UP000008143};
RN   [1] {ECO:0000313|Ensembl:ENSXETP00000013734}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000013734};
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L.,
RA   Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E.,
RA   Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T.,
RA   Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M.,
RA   Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N.,
RA   Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D.,
RA   Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B.,
RA   Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M.,
RA   Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [2] {ECO:0000313|Ensembl:ENSXETP00000013734}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
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DR   EMBL; AAMC01054181; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01054182; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01054183; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01054184; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01054185; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01054186; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01054187; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01054188; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8364.ENSXETP00000013734; -.
DR   PaxDb; F7E2D6; -.
DR   Ensembl; ENSXETT00000013734; ENSXETP00000013734; ENSXETG00000006267.
DR   Xenbase; XB-GENE-987988; ralgds.
DR   eggNOG; KOG3629; Eukaryota.
DR   eggNOG; ENOG410ZUT5; LUCA.
DR   GeneTree; ENSGT00940000153181; -.
DR   InParanoid; F7E2D6; -.
DR   OMA; NDSTYVT; -.
DR   TreeFam; TF315204; -.
DR   Reactome; R-XTR-171007; p38MAPK events.
DR   Proteomes; UP000008143; Unassembled WGS sequence.
DR   Bgee; ENSXETG00000006267; Expressed in 15 organ(s), highest expression level in brain.
DR   ExpressionAtlas; F7E2D6; baseline.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; -; 1.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR015758; RalGDS.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; PTHR23113; 1.
DR   PANTHER; PTHR23113:SF35; PTHR23113:SF35; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; SSF48366; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008143};
KW   Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-
KW   ProRule:PRU00168, ECO:0000256|SAAS:SAAS01081641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT   DOMAIN       86    216       N-terminal Ras-GEF. {ECO:0000259|PROSITE:
FT                                PS50212}.
FT   DOMAIN      305    570       Ras-GEF. {ECO:0000259|PROSITE:PS50009}.
FT   DOMAIN      721    808       Ras-associating. {ECO:0000259|PROSITE:
FT                                PS50200}.
FT   REGION      672    697       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F7E2D6}.
SQ   SEQUENCE   837 AA;  93951 MW;  B55668F329065AFA CRC64;
     MRSLWDGVRL EVAGESSPVV LSSFTQLDPD LPPLESSTQE IGEEVDDGVI YSISLRKVQL
     HHTANKGQRW LGVENDSGLS LYETCKVRSI KAGTLEKLVE YLVSAFKGND STYVTIFLCT
     YRAFATTKQV LDLLLNRFGR LHPQINGEHS HNSVDDRLEL KNTISSILGA WLDQYSEDFR
     QAPDYTCLKQ LITYVRHNIP GSDLERRACN LLTQFKRQQI SALEPDGRAT SWVLQIFGNN
     WTVGGGRGIF NTRAPQESWW PISSFFIAEL SLLLCVSVVD HTSCTLRLVE EPLLSDGKPD
     FLSFRQDMLA EQFTVMDAEL FKKVVPYHCL GCIWSQRDKK GKEHLAPTIR ATVSQFNSVT
     NCVISTCLCD RSLKPQQRAK VIERWIEVAR ECRILKNFSS LRAILSALQC NAIHRLKKTW
     DEVSRESYRI FMELSEIFSD ENNHSLSREL LIKEGTSKFA TLDINPKRAQ KRQQQQREMG
     VMQGTIPYLG TFLTDLVMLD TAMKDYLESG LINFEKRRKE FEVIAQIKLL QSACNNYSFL
     PDESFVEWFH SVERLTEAES YSLSCEIEPL SESASNTLKA KKNTGIIKRW SDRQPPSSEP
     CPSVSSHSKS FDQLKCSPHL CGGDTTDSLS VTSAGSSSSD VDEINISFVP ESPDCQEKKF
     WESTSLSSLD TSGIGSGSSS ASSSSVSSTP VSASRTHKRS VSGISSYSSL SLPLYNQQID
     DCCIIRVSLD VDNGNMYKSI LVTSQDKTPV VIRKAMAKHN IDGERAEDYE LVQIISEERE
     LKIPDNANVF YAMNSGANYD FVLKKRGFSK GVKIKQGSSS TLPRMKQKGL KIAKGIF
//
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