ID F7E373_HORSE Unreviewed; 1561 AA.
AC F7E373;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 4.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Sorbin and SH3 domain containing 1 {ECO:0000313|Ensembl:ENSECAP00000017020.4};
GN Name=SORBS1 {ECO:0000313|Ensembl:ENSECAP00000017020.4,
GN ECO:0000313|VGNC:VGNC:23445};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000017020.4, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000017020.4, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017020.4,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000017020.4}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017020.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F7E373; -.
DR Ensembl; ENSECAT00000020722.4; ENSECAP00000017020.4; ENSECAG00000018511.4.
DR VGNC; VGNC:23445; SORBS1.
DR GeneTree; ENSGT00940000158658; -.
DR TreeFam; TF320680; -.
DR Proteomes; UP000002281; Chromosome 1.
DR Bgee; ENSECAG00000018511; Expressed in muscle tissue and 23 other cell types or tissues.
DR ExpressionAtlas; F7E373; baseline.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005158; F:insulin receptor binding; IEA:Ensembl.
DR GO; GO:0030159; F:signaling receptor complex adaptor activity; IEA:Ensembl.
DR CDD; cd11919; SH3_Sorbs1_1; 1.
DR CDD; cd11922; SH3_Sorbs1_2; 1.
DR CDD; cd11916; SH3_Sorbs1_3; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR003127; SoHo_dom.
DR InterPro; IPR035606; SORBS1_SH3.
DR InterPro; IPR035610; SORBS1_SH3_1.
DR InterPro; IPR035611; SORBS1_SH3_2.
DR PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR14167:SF64; SORBIN AND SH3 DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF14604; SH3_9; 1.
DR Pfam; PF02208; Sorb; 1.
DR SMART; SM00326; SH3; 3.
DR SMART; SM00459; Sorb; 1.
DR SUPFAM; SSF50044; SH3-domain; 3.
DR PROSITE; PS50002; SH3; 3.
DR PROSITE; PS50831; SOHO; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:F7E373};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 592..674
FT /note="SoHo"
FT /evidence="ECO:0000259|PROSITE:PS50831"
FT DOMAIN 998..1057
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1072..1133
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1500..1561
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 77..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 164..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 279..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 398..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 631..738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 827..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 897..922
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1367..1431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1467..1497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..424
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..478
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..530
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 577..595
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 668..684
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 718..738
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 833..856
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 903..917
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1395..1409
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1472..1497
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1561 AA; 172008 MW; B0E5B5DCEEAE1A21 CRC64;
MSSECDVGAS KAVVNGLAPG SNGQDKATAD PLRARSISAV KIIPVKTVRN SSGLVLPPDM
DPTKICTGKG AVTLRASSSY REIPSSGPVS PQETPKHESK PDEWRLSSNA DANGNAQPSS
LAAKGYRSVH PNLPSDKPQI LSPLHPLLPK EDCFAWQPPA ICGPYKDSLY RSSPKPYVPP
GTPSQQNPSR PRPVSAPLAA RSAPKGVMRP GPSLLGSTFP GASSQPQHHY VASRTVYSEN
VSSNPRHEVV GKKKVSSLYV PCLSNNIRLV ALENSSCVAR DPAKGTPSEA AATRAPAPSI
VSRTAGKGKP LSVPPPDPPK LFFDIRKDGE SPSLGTRPSF PDAVRPPVLG PQVTSDPENR
KRKEPYLFQP CYPAKDATSS SPAQPEVIVV PLYLVNTDRG QEGTTRPPAS LGPLGPPVPA
TAPAGSPLTL PTLDDFIPPR LQRRPHHSQP ASTPGSFPPV SQTPPSFSPP PPLVPPVPEG
LHRVSEPDLT GAVSSTDSSP LLNEVSSSHV GTDSQTFAPV SKPTSAYPST TIVNPTIVLL
QHNREQQKRL SSLSDPVSER RVGEQASVPT QEKATSPGRA TEKKAKDDSR RVVKSAQDLS
DVSMDEVGIP LRNTERSKDW YKTMFKQIHK LNRDTPEENP YFPTYKFPEL PEIQQNSEDD
DSDLYSPRYS FSEDTKSPLS VPRSKSEMSY IDGEKVVKRS ATLPLPARSS SLKSSPERND
WEPPDKKVDT RKYRAEPKSI YEYQPGKSSV LTNEKMSRDI SPEEIDLKNE PWYKFFSELE
FGKPPPKKIW DYTPGDCSIL PREDRKTNLE KDLNLCQTEL EADLEKLETL NKTPSAELAQ
SSAVSPTPEI SSEPPGYIYS SNFHAVKRES DGAPGDLSSL ENERQIYKSV LEGGDIPLQG
LSGLKRPSSS ASTKDSESPR HFIPADYLES TEEFIRRRHD DKEKLLADQR RLKREQEEAD
IAARRHTGVI PTHHQFITNE RFGDLLNIDD TAKRKSGSEM RPARAKFDFK AQTLKELPLQ
KGDIVYIYKQ IDQNWYEGEH HGRVGIFPRT YIELLPPAEK AQPKKLTPVQ VLEYGEAVAK
FNFNGDTQVE MSFRKGERIM LLRQVDENWY EGRIPGTSRQ GIFPITYVDV IKRPLVKNPV
DYIDLPFSSS PSRSATASPQ FPSHSKLIMR APSSLPHPHR ALSPEMHAVT SEWISLTVGV
PGRRPLALTP PLPPLPEASI YDTDHLALMA RPSPSLSLSL PHSSWSDRST PRSIASPLAL
PAPHKAYSLA PSTQASLHVN GDSGIHMPTS GVRQDSFSQP PLGSSDRVIS ELSNAFSSQG
KRQPWREESR WYERKAEREA GERCPGGPKI SKKSCLKPSD VVRCLSTEQR LSDLHTPEES
RPSKPLGSPF PGREAEQTEL HRGGEQAERK AARSGVSQPS HHSLRAGPDL TESEKSYVEA
VCNEIINIAE KSVHYCSTVS HPLDFHHKVS PSDNKSSLII SQQPQAQQRR VTPDRSQTSQ
DLLSYQALYS YIPQNDDELE LRDGDIVDVM EKCDDGWFVG TSRRTRQFGT FPGNYVKPLY
L
//
