ID F7EAG4_XENTR Unreviewed; 482 AA.
AC F7EAG4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Dihydrouridine synthase 2 {ECO:0000313|Ensembl:ENSXETP00000011968};
GN Name=dus2 {ECO:0000313|Ensembl:ENSXETP00000011968};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000011968};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000011968}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000011968};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000011968}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000256|ARBA:ARBA00001917};
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DR AlphaFoldDB; F7EAG4; -.
DR STRING; 8364.ENSXETP00000011968; -.
DR PaxDb; 8364-ENSXETP00000036232; -.
DR Ensembl; ENSXETT00000011968; ENSXETP00000011968; ENSXETG00000005436.
DR AGR; Xenbase:XB-GENE-1017020; -.
DR AGR; Xenbase:XB-GENE-979524; -.
DR Xenbase; XB-GENE-1017020; dus2.
DR eggNOG; KOG2334; Eukaryota.
DR HOGENOM; CLU_013299_3_0_1; -.
DR OrthoDB; 4047619at2759; -.
DR TreeFam; TF106151; -.
DR Bgee; ENSXETG00000005436; Expressed in egg cell and 15 other cell types or tissues.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR GO; GO:0017150; F:tRNA dihydrouridine synthase activity; IEA:InterPro.
DR CDD; cd19871; DSRM_DUS2L; 1.
DR CDD; cd02801; DUS_like_FMN; 1.
DR Gene3D; 3.30.160.20; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR035587; DUS-like_FMN-bd.
DR InterPro; IPR044463; DUS2_DSRM.
DR InterPro; IPR018517; tRNA_hU_synthase_CS.
DR PANTHER; PTHR45936; TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE; 1.
DR PANTHER; PTHR45936:SF1; TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE; 1.
DR Pfam; PF00035; dsrm; 1.
DR Pfam; PF01207; Dus; 1.
DR SMART; SM00358; DSRM; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR SUPFAM; SSF51395; FMN-linked oxidoreductases; 1.
DR PROSITE; PS50137; DS_RBD; 1.
DR PROSITE; PS01136; UPF0034; 1.
PE 4: Predicted;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW FMN {ECO:0000256|ARBA:ARBA00022643};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 353..420
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT REGION 439..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..463
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 482 AA; 54551 MW; 86DE99DD52D28685 CRC64;
MMGLSFRDKN ILGPMVRVGT LPMRLLALDY GADIVYSEEL VDIKMLQCKR VVNDVLHTVD
YVSPTERVIF QTCERERHSV VFQMVRQNDI AAIDINMGCP KEYSTKGGMG AALLLCPEKI
EMILSTLVKG ISKPITCKIR ILPSLTETIS LVKLIEKTGV AAIAVHGRSK NERPQHPVHC
DVIKAISQAV SIPVIANGGS QEFIRQFQDI SAFRSVTSAS SVMLARAAMW NPSVFRPEGM
LPVETVIRDY IAYAVQYDNH YTNTKYCLCQ MLRDQLESPL GKRLHAAQST LEICEVFEMS
DFYESCRVAQ KAKKADLQSV GLVAALENDD AEDRNIISLP IRFDKRNYMS QITPKMLLLE
WCRKRKLPQP VYHTVQRPVD KFFQSVVKVD EMQYASTLWD KSKKLAEQSA AIVCLHTLGL
TEIKMNESDF AQKRKRKLQC QEDEGTRSLK EEHNKKLHQN GSEHRPLIQD ATTFANQSGT
HN
//